Closing down

In June, the University of the Arts issued a startling announcement: the US college would be closing permanently, ending 150-odd years of tuition for musicians and artists, dancers and designers. The decision by Philadelphia-based UArt, as it is known, was driven by a steep drop in enrolment – student numbers have plunged by nearly half since 2009 – and “significant, unanticipated expenses”.

“Despite our best efforts, we could not ultimately identify a viable path for the institution to remain open and in the service of its mission,” the college’s trustees said in a statement. The university is now being investigated, to figure out how its coffers suddenly ran so dry, leaving around 1,300 students in the lurch. Some have even sued the school.

UArt is part of a disturbing trend: the US has seen an alarming rate of private colleges shutting down, with approximately two institutions closing their doors every month, estimates the State Higher Education Executive Officers Association. This unsettling occurrence is not isolated to America alone. Across the Atlantic, universities in the UK are also grappling with severe financial challenges and face an elevated risk of closure. In June, British schools urged the new Labour government to raise tuition fees to address the “crisis” in higher education.

The great shuttering of universities can be attributed to a confluence of factors that have exerted pressure on the financial and operational viability of these institutions.

One of the primary reasons is demographic change. In the US, for instance, the number of college-age individuals has steadily declined. This trend, often referred to as the “enrolment cliff”, is attributed to reduced birth rates following the 2008 financial crisis, leading to fewer students reaching college age in subsequent years.

For several decades, from the early 1970s to 2007, the US birth rate for women aged 15 to 44 remained relatively stable, fluctuating between 65 and 70 births per 1,000 women. However, starting in 2008, the birth rate dropped year after year. By 2020, it had reached 56 births per 1,000 women, the lowest in American history. This has created a demographic time-bomb for universities. Nathan Grawe, an economist at Carleton College in Minnesota, forecasts a 15 percent decline in the college-going population between 2025 and 2029 – a trend that’s likely to continue thereafter.

“Students are going to be a hot commodity, a scarce resource,” says Grawe. “It’s going to be harder during this period for institutions to aggressively increase tuition. It may be a time period when it’s a little easier on parents and students who are negotiating over the financial aid package.”

This demographic shift has already led to a big reduction in college enrolments, directly impacting the revenue generated from tuition fees. According to the National Center for Education Statistics, from 2010 to 2021, the total number of undergraduates enrolled in US schools decreased by 15 percent, dropping from 18.1 million to 15.4 million students. Although there has been a recent rise in enrolment, with undergraduate numbers in spring 2024, this growth was mainly fuelled by community colleges. The overall trend over the past decade has been a decline in college enrolments.

Several factors contribute to this decline, including reduced immigration and fewer international students – especially because of changes in immigration policies under the Donald Trump presidency from 2017 to 2021.

Rising scepticism about the value of higher education due to increasing costs and student debt are also concerns. At the top end of the market, yearly tuition fees in the US can easily surpass $60,000. A Wall Street Journal survey found that 56 percent of Americans doubt that earning a four-year degree is worth the cost. “More and more young people are worried about going into debt and are worried about whether or not it’s worth the investment,” says Angel Perez, Chief Executive of the National Association for College Admission Counseling (NACAC).

For many private colleges, tuition fees are the lifeblood of their operations. With fewer students enrolling, these institutions find themselves in a precarious financial position, struggling to cover their operational costs. Many private colleges also operate on tight budgets and have limited endowments. As operational costs continue to rise, particularly in maintaining facilities and paying faculty salaries, these institutions struggle to balance their budgets. Without adequate financial reserves, they become increasingly vulnerable to economic downturns and unexpected expenses – like UArt did. This financial instability often leads to difficult decisions, including staff layoffs, programme cuts, and, in the worst cases, closure.

Making matters worse is that higher education is becoming increasingly competitive. Students have a broader array of educational options at their disposal, including online courses and vocational training programmes.

These alternatives often come at a lower cost and offer more flexibility compared to traditional four-year degrees. Consequently, traditional universities face the challenge of adapting to these changing preferences and proving the value of their programmes. The ability to demonstrate a clear return on investment has become crucial in attracting and retaining students.

Changes in government policies and funding cuts have also played a role in the financial struggles of universities. In the UK, schools face financial challenges due to a decline in international students – and their typically much-higher fees – plus a decade-long freeze on domestic tuition fees, causing schools to lose an average of £2,500 per domestic student.

Read the full article on QS Insights Magazine.

HKAPA continues to embrace world, nurture next generation of performing artists

The Hong Kong Academy for Performing Arts strives to provide the students with opportunities to engage in international competitions and exchange programmes in the Mainland and overseas to widen their horizons. In the last academic year, students of the School of Music travelled to various places, including the Mainland, Switzerland, the United States, Thailand, etc., to collaborate with local artists. These programmes have helped students further arts and cultural development on the global stage.

Implementation of visiting professor Melakhat Atasever program at the Department of Obstetrics and Gynecology at Asfendiyarov KazNMU

From 18.06.24 to 29.06.24, the training program of visiting professor Melahat Atasever from Turkey was held. Professor Melahat Atasever stands out with a unique combination of extensive medical experience, deep scientific knowledge, and an active role in the international community of obstetrics and gynecology specialists. Her professional path began with medical education at the prestigious Ankara University, after which she continued through various scientific and practical sites both in Turkey and abroad. During her professional career, she demonstrated unique skills in various aspects of the specialty, including surgical treatment methods and innovative approaches to infertility and ART. She is a developer of innovative methods for the treatment of infertility and ART, including the use of stem cells and exosomes. Professor Atasever has more than 29 scientific publications in journals included in the Scopus and Web of Science databases, Hirsch Index – 7. Number of citations in Google Akademik 206; Scopus 88; Web of Science 90.

The professor’s visit took place in the form of lectures, seminars, scientific and methodological work for residents (specialty obstetrics and gynecology), teachers, as well as for practicing doctors and mentors of the department’s clinical bases. The training session included the following current topics in obstetrics and gynecology.

“The project of the visiting professor’s effectiveness includes the introduction and development of innovative methods of treating infertility in women with repeated failures of the ART program in Kazakhstan, which will increase the effectiveness of ART. It is planned to conduct scientific research in this area and publish scientific articles.”

13th ICAS concluded, IIAS to continue collaboration with UNAIR

The 13th International Convention of Asia Scholars (ICAS) officially concluded on Thursday, August 1, 2024. Universitas Airlangga (UNAIR), through the Airlangga Institute of Indian Ocean Crossroads (AIIOC), hosted this prestigious event, which commenced on Sunday, July 28, 2024.

13th ICAS was made possible through a robust partnership between UNAIR’s AIIOC and the International Institute for Asian Studies (IIAS), based in the Netherlands. Although 13th ICAS has been concluded, the collaboration between UNAIR and IIAS is set to continue.

Philippe Peycam, Director of IIAS, mentioned that the next step is to further develop AIIOC into a more significant unit. AIIOC initially started as a collaborative project between UNAIR and IIAS. “We will continue to work together to make AIIOC a successful unit, not just for the industry but also for the Indonesian government,” he stated.

Peycam noted that AIIOC has the potential to offer broader benefits to a wider audience. 13th ICAS has marked a significant milestone in AIIOC’s rapid development. “AIIOC has the potential to benefit not only UNAIR, the city of Surabaya, or East Java but also Indonesia and the entire world,” he said.

Exploring further collaboration

One of the potential areas of continued collaboration between UNAIR and IIAS is the establishment of a fellowship program. This program would provide opportunities for individuals to pursue further studies abroad.

“A fellowship will facilitate Indonesians in various activities, such as pursuing a PhD overseas and returning to their home country after the fellowship,” Peycam remarked on Thursday, August 1, 2024.

The fellowship can ease the exchange of knowledge across various disciplines. Peycam believes that AIIOC can grow into a research center as significant as IIAS, which has already become the largest Asian research center.

“Many people from around the world want to visit IIAS. Similarly, AIIOC has the opportunity to become a large interdisciplinary research center. They have successfully organized 13th ICAS, focusing on learning, discussion, and interdisciplinary research,” he explained.

Aiming reputation improvement

Peycam expressed his admiration for UNAIR’s efforts and dedication to its collaboration. UNAIR’s enthusiasm to enhance its reputation was highly praised by Peycam.

“UNAIR is always obsessed with enhancing its reputation, making various efforts including improving the quality of education. If UNAIR didn’t have this obsession, our collaboration might not have continued,” he said in an exclusive interview with UNAIR NEWS.

AIIOC Potential

Peycam is confident that within the next five to ten years, AIIOC will gain global recognition. An expanding AIIOC will facilitate the exchange of knowledge between countries.

“If people want to learn about Europe, Europeans can come to AIIOC without Indonesians needing to go to Europe. Although this requires a long process, I believe with cooperation, it is not impossible,” he emphasized.

Students of NTU «KhPI» became the champions of the International IT Olympiad for the fifth time

NTU «KhPI» took the first team place among higher education institutions in the final of the International Student Olympiad in Information Technology «IT-Universe-2024». Kharkiv Polytechnics became the champions of this tournament for the fifth time. 15 students from different departments of Kharkiv Polytechnic made it to the final of the tournament. In total, almost 200 students from 30 educational institutions participated in the final.

Thus, a team of students from the Department of Computer Engineering and Programming (CEP) of the Educational and Scientific Institute of Computer Science and Information Technologies of NTU «Kharkiv Polytechnic Institute» won the first place in the Mobile Application Development competition of the International Student Olympiad in the field of information technology «IT-Universe-2024». The work «AR Multipl STOP» by Yelyzaveta Bondarenko and Georgiy Gryanyk was recognized as the best among all the works presented in the final.

It should be noted that this is the third year in a row that Georgiy Gryanyk has won this competition and the third time in general. He demonstrated the real functioning of his development at a high professional level and showed the best result, scoring the maximum five points. In addition, the tournament champion entered the top ten in the Linux Administration competition. For the victory, the students of NTU «KhPI» received diplomas and a prize from the sponsors – gift certificates in the amount of UAH 3000. The head of the winning team is Olena Chernykh, a professor at the Department of Computer Engineering and Programming of the NTU «KhPI».

The second place in the competition «Development of mobile applications» of «IT-Universe-2024» was also taken by a team of students from CЕP department of NTU «KhPI» consisting of Bohdan Yakilevsky and Andriy Kalashnikov. Their work «FurniCrush» scored three points out of five possible. The students received diplomas and a prize from the sponsors – gift certificates in the amount of UAH 1000. The team’s scientific adviser is Serhii Mezeritskyi, a senior lecturer at the CEP department.

Students of the Department of Computer Engineering and Programming of NTU «KhPI» Olga Ilchenko and Yaroslav Horlo took the 3rd place in the competition «Design of marketing materials for advertising a new business» of the International Student Olympiad in the field of information technology «IT-Universe-2024». In the finals, they presented their work «Design of marketing materials for the «Your Paws» store. The students received diplomas and a prize from the sponsors – gift certificates in the amount of UAH 500. The team leader is senior lecturer Serhii Mezeritskyi. Another development of the representatives of the KIP Department of Kharkiv Polytechnic Maxim Kolisnichenko and Yelyzaveta Bondarenko, «Company Logo», took 6th place. The project manager is Olena Chernykh, professor of the CEP department.

In the competition «Solving practical problems using artificial intelligence» «IT-Universe-2024» The 2nd place was won by a team of students from the Department of Computer Modeling of Processes and Systems of NTU «KhPI» and the Department of Mathematical Modeling and Intelligent Computing in Engineering of the Educational and Scientific Institute of Computer Modeling, Applied Physics and Mathematics of NTU «KhPI» consisting of Mark Gimonov and Ilya Govorukha, respectively. In the finals, they presented their work «Development of a system for detecting and classifying land explosive objects using machine learning (MineGuard)». The students received diplomas and a prize from the sponsors – gift certificates in the amount of UAH 1000. The project was supervised by Volodymyr Metelev, associate professor of the Department of Computer Modeling of Processes and Systems at NTU KhPI, and Oleksiy Vodka, head of the Department of Mathematical Modeling and Intelligent Computing in Engineering at NTU «KhPI».

Students of the Department of Software Engineering and Intelligent Management Technologies of NTU «KhPI» Daniel Dunay and Ruslan Kukuev and the Department of System Analysis and Information and Analytical Technologies of NTU «KhPI» Stephen Kimmel were also invited to the final of this competition to present their work «Emotion Recognition System». Another team of students from the Department of Computer Engineering and Programming of NTU «KhPI», Mykola Svishchev and Serhiy Ivashchuk, although they did not make it to the final of the Olympiad this year, are aiming for a successful performance at the tournament next year. They performed their work «Music Equalization System – AI music equalization system» under the guidance of senior lecturer Serhii Mezeritskyi.

In the competition «IT Project Management» of the International Student Olympiad in the field of information technology «IT-Universe-2024» 24 students from different educational institutions took part. Angelina Danilova, a student of the Department of Project Management in Information Technology at NTU «KhPI», took 2nd place with 94 points, lagging behind the winner by only 3 points. She received a diploma and a prize from the sponsors – a certificate in the amount of 2000 UAH. The academic advisor of the student winner is professor Maryna Hrynchenko, head of the Department of Project Management in Information Technology at NTU «KhPI».

The winner of the competition «Linux Administration» become Denys Bondar, a student of the Department of Computer Modeling of Processes and Systems of NTU «KhPI». He was awarded a diploma and a prize from the sponsors – a certificate in the amount of 5000 UAH. The champion’s scientific advisor is Oksana Tatarinova, associate professor of the Department of Computer Modeling of Processes and Systems of NTU «KhPI». The 3rd place was won by Yelyzaveta Bondarenko, a student of the Department of Computer Engineering and Programming of Kharkiv Polytechnic, who received a diploma and a certificate in the amount of UAH 1000. The coordinator and coach of the student-winner is Viktor Chelak, an assistant of the Department of Computer Engineering and Programming. Oleksandr Shalimov, a student of the Department of Automation and Control in Technical Systems of NTU «KhPI», also became one of the «seven» strongest competitors.

According to the results of the Olympiad «IT-Universe-2024», NTU «KhPI» won the first team place among the higher education institutions participating in the competition. The mentor and official responsible representative of the students of NTU «KhPI» was the senior lecturer of the Department of Computer Engineering and Programming Serhiy Mezeritsky, and his helper was the assistant of the same department Viktor Chelak.

It should be noted that for the entire period of participation in the International Student Olympiad in the field of information technology «IT-Universe», starting from 2014, Kharkiv Polytechnic has become the winner of this prestigious tournament in the team competition for the fifth time (2017, 2019, 2021, 2023 and 2024), and the Department of Computer Engineering and Programming is the leader in the number of presented developments and prizes in the finals of the competition.

Universitas Sumatera Utara, Humbang Hasundutan Regency: Advancing disaster mitigation through collaborative initiatives

Humbang Hasundutan (Humbahas) Regency is one of the disaster-prone areas in North Sumatera. The area is prone to landslides, which are exacerbated by deforestation and prolonged rainfall. The Humbahas region has a high rainfall intensity with a poor surface drainage system. This triggers hydrometeorological disasters in the form of floods and landslides. From these disasters, the society felt great losses such as infrastructure damage in residential areas, damage to plantations, rice fields, and crop failure. As an anticipatory step and implementation of the Tri Dharma of Higher Education, Lembaga Pengabdian Pada Masyarakat Universitas Sumatera Utara (LPPM USU) organizes disaster mitigation and adaptation activities through the Society Service Program (PKM) thematic disaster mitigation and adaptation.

The program, launched on July 4th, 2024, at the Bukit Barisan Hall in Humbahas Regency, represents a crucial collaboration between Lembaga Pengabdian Pada Masyarakat (LPPM) USU and the Humbahas regional government. This initiative aims to equip the region with the tools and knowledge to effectively minimize the impact of disasters. Tua Marsatti Marbun as a representative of the Humbahas Regency government stated about this launch signifies a commitment to provide stakeholders involved in the disaster mitigation program with the necessary resources and infrastructur.

The program operates under two distinct schemes: the PKM Assisted Village Program and the PKM Regular Mono Year. The PKM Assisted Village Program takes a long-term approach, providing multi-year support to designated villages. Conversely, the PKM Regular Mono Year program focuses on short-term interventions. Dr. Oding Effendy, the implementing coordinator of the disaster mitigation thematic activities, elaborated that both programs will run for seven months each year, spanning a total of nine locations and encompassing a range of activities.

The program tackles disaster preparedness on multiple fronts. One key activity involves the formation of Disaster Resilient Villages (DESTANA) which empowers communities to manage potential threats, environmental conservation (tree planting), economic development (sustainable tourism), and public health improvement. Furthermore, a unique initiative involves designing disaster mitigation gymnastics for elementary school students, aiming to instill a culture of preparedness from a young age.

The program launch fostered a vibrant discussion with Ir. Yusak Maryunianta, M.P. (Chief Executive of PKM Assisted Village), Dra. Fatma Wardy Lubis, M.A. (Chief Executive of PKM Regular Mono Year), Benthon Juber Lumban Gaol, ST., M.Si. (Head of BPBD North Sumatera), and Manutur Parulian Naibaho, S.Sos., S.H., M.Si. (Head of Prevention and Preparedness). One crucial concern raised was the need to address the underlying economic factors that contribute to environmental destruction. Recognizing this, USU emphasizes a holistic approach, extending its support beyond disaster mitigation and adaptation to encompass local economic development initiatives. By empowering communities economically, the program aims to reduce the pressure on natural resources driven by poverty. Through this activity, it is hoped that the entire implementation team and also the stakeholders involved will be able to realize each planned program so that it is right on target according to the needs of the society in Humbang Hasundutan Regency.

Global University Systems becomes CANIE Accord signatory

Global University Systems, the international education group, announces it has become a signatory to the CANIE Accord (Climate Action Network for International Educators), as part of its long-term ESG and group impact strategy.

Global University Systems is a higher and life-long learning group with a network of internationally recognised education institutions. The group empowers students to transform their lives through education. Becoming an accord signatory is an important step for the global business and its impact strategy.

CANIE is an organisation that is catalysing climate action in the international education sector. Concentrating its efforts on action-oriented advocacy, education, and connection, the Accord is a public commitment to climate action. It was developed to engage international education bodies, associations, higher education institutions, university networks, as well as media, national governments, corporations, supranational bodies, scholarship bodies.

The CANIE Accord, and accompanying Glasgow Paper, represent the international education sector’s climate ambitions and commitment to align with scientific recommendations and global climate agreements. Global University Systems is strengthening and accelerating the international education sector’s collective response to the climate crisis by becoming a Signatory.

Yuliya Etingen, Chief Impact Officer, Global University Systems says, “We’re committed to having a positive effect on the world around us, creating a brighter, more sustainable world through education. Committing to ESG principles and ensuring that they’re seamlessly woven into our Group and our institutions’ strategy is paramount.

“Becoming a signatory to CANIE is an important step for our organisation as part of our ESG strategy. It enables us to meet challenges head on and we are harnessing the abundant energy and commitment within our network to foster necessary positive change across our group.”

CANIE co-founder and President of the Board, Ailsa Lamont says, “I applaud Global University Systems on showing such leadership in our sector’s transition to more climate-conscious operations. By signing up to the CANIE Accord, international education leaders commit to real, practical action to combat global temperature rise and, crucially, to doing so in a way that is grounded in social justice.’’

Thammasat debate team awarded championship in “Udom Debate”

Thammasat Debate Team” has been awarded the Royal Trophy, the first-place award, by Her Royal Highness Princess Maha Chakri Sirindhorn for the academic year 2023 in the 26th Freshy Debate for Higher Education Institutes by the Higher Education Rhetoric Group (Udom Vatasil) at Thammasat University, Rangsit Center.

Students participated are:

1. Natchalida Nakngam, 4th year, Faculty of Liberal Arts
2. Sueksa Sahunalu, 4th year, Faculty of Liberal Arts
3. Nanthasawat Wongrianniyom, 4th year, Faculty of Law
4. Thanaporn Kamnerdkarn, 3rd year, Faculty of Pharmacy
5. Pinpak Jotikabukkhana, 2nd year, Faculty of Political Science
6. Nannapat Phongwitoon, 2nd year, Faculty of Liberal Arts
7. Napat Kongmuang, 2nd year, Faculty of Science and Technology
8. Kantha Duang-in, 2nd year, Thammasat Business School

Sueksa Sahunalu, a 4th year student of the Faculty of Liberal Arts, one of the debate team members awarded as an ‘Outstanding Debater’, shares thoughts and experiences gained from participating in this competition.

As a winner

We felt immense joy because ‘Udom Debate’ is a dream for many debaters, and it is also a stage with a memorable history. We, as debaters, hope to be on this stage at least once in our lifetime. Initially, we thought there would be no chance after being separated for years during the COVID. Some of us are in our last year of study. However, in the end, the Udom Debate Group managed to organize and succeed.

We are also proud of ourselves, our teammates, and everyone behind the scenes who helped make the team successful. Because we are the ‘Thammasat University Debate Team,’ the success that occurred did not solely result from the four of us standing on stage. Instead, it is a success that, if any one of us were missing, we might not have achieved our goal.

What is the technique for winning the championship?

Before the competition, we would spend our weeks preparing. We had to practice speaking and gather information to compete every Saturday. The competition period was a time when we had to devote ourselves to it fully, feeling like we spent a lot of energy. The competition spanned over several months, and when combined with practice time, it was quite a long period of working together.

The technique that led us to victory, I believe, is teamwork. As mentioned, our victory didn’t come solely from the four debaters. Before we could present our stance, it required going through various team processes and stages. Everyone had equal responsibilities, and ultimately, the success belonged to the team as a whole.

What is the key to debating?

I believe the key to debating lies in rational thinking and listening attentively. In each debate, we must begin by considering what questions our opponents are posing and how we can respond. This involves planning how to present our arguments logically, supported by evidence, and persuading the audience that what we are saying is ‘the truth’ through our presentation of all the points. Subsequently, we must also be good listeners.

Therefore, the art of debating helps us in learning and navigating life. It prompts us to think before acting and to choose our words carefully during classroom presentations or reports preparations that require critical thinking and conveying content. Additionally, it also enhances public speaking skills. We become more confident in expressing our thoughts, unafraid of being judged or criticized. Wherever we go, we’re assuredly not afraid to speak up, I guarantee you there won’t be any ‘dead air’.

Breakthrough in plant disease: New enzyme could lead to anti-bacterial pesticides

Scientists from Tokyo University of Science uncover a pivotal enzyme, XccOpgD, and its critical role in synthesizing CβG16α, a key compound used by Xanthomonas pathogens to enhance their virulence against plants. This breakthrough opens new avenues for developing targeted pesticides that combat plant diseases without harming beneficial organisms. Insights into XccOpgD’s enzymatic mechanism and optimal conditions offer promising prospects for sustainable agriculture, bolstering crop resilience and global food security while minimizing environmental impact.

Plant diseases pose significant challenges to agricultural productivity, presenting formidable hurdles that require urgent attention. Left unchecked, these diseases can spread rapidly, inflicting widespread damage on crops and leading to reduced yields and substantial economic losses. Therefore, accurately identifying the pathogens responsible for these diseases is crucial. This identification allows for targeted interventions that minimize risks and effectively mitigate the agricultural impacts.

Xanthomonas species are notorious plant pathogens that affect a broad spectrum of hosts, including key crops like rice, wheat, and tomatoes. These pathogens augment their pathogenicity by utilizing α-1,6-cyclized β-1,2-glucohexadecaose (CβG16α) to suppress essential plant defense mechanisms, such as the expression of pathogenesis-related proteins and the accumulation of callose.

In a recent breakthrough published on June 19, 2024, in the Journal of the American Chemical Society, a team of researchers led by Associate Professor Masahiro Nakajima from Tokyo University of Science unveiled a significant discovery. They identified XccOpgD, a glycoside hydrolase (GH186) found in X. campestris pv campestris which plays a pivotal role in the biosynthesis of CβG16α. The research team also included Mr. Sei Motouchi from Tokyo University of Science, Principal Scientist Shiro Komba from the Institute of Food Research, NARO, and Hiroyuki Nakai from Niigata University.

“Glycan structures are intricate and multifaceted and fulfill diverse crucial roles in nature and organisms. Enzymes synthesize and degrade glycans, exhibiting diverse structures and functions that correspond to the glycan diversity. However, our understanding of these enzymes is still limited, which drives the search for new enzymes with varied new potentials,” explains Prof. Nakajima, elaborating on the study’s rationale.

The team conducted biochemical analysis to elucidate the role of XccOpgD in CβG16α biosynthesis. Advanced techniques such as X-ray crystallography were employed as structural analysis to unravel the enzyme’s catalytic mechanism and substrate specificity.

These efforts have yielded profound insights. XccOpgD belongs to the GH186 family, essential for regulating bacterial cell wall components. Unlike the first identified GH186 enzymes, XccOpgD exhibits an unprecedented enzymatic mechanism known as anomer-inverting transglycosylation.

“Reactions of typical GH enzymes are classified into four types by combination of retaining or inverting, and reaction with water (hydrolysis) or sugar (transglycosylation) theoretically. However, one classification is missing somehow in a long history of researches on carbohydrate associated enzymes and we discovered the missing classification. This breakthrough was made possible by unique structural environment, opening new possibilities for enzyme-based glycosylation,” explains Prof. Nakajima. Moreover, the sugar chains synthesized through this mechanism are not merely minor components but rather essential structures utilized by various Gram-negative bacteria in nature for pathogenic purposes.

Detailed studies revealed that linear β-1,2-glucan was converted to cyclic compound and the compound was identified as CβG16α using nuclear magnetic resonance. Structural analysis of the Michaelis complex identified crucial substrate binding residues, further elucidating specific interactions along the glucan chain. Notably, XccOpgD utilizes an anomer-inverting transglycosylation mechanism, with D379 and D291 playing pivotal roles as catalysts.

These findings deepen our understanding and open avenues for developing targeted strategies against Xanthomonas-induced plant diseases. “We are expecting a pesticide concept targeting this enzyme homolog in the future. Unlike fungicides that promote the emergence of drug-resistant bacteria in soil, targeting this enzyme could potentially inhibit pathogenicity without causing sterilization. Enzyme homologs identified in this study may serve as promising structure-based drug targets, offering a potential solution to the issue of drug-resistant bacteria,” says a hopeful Prof. Nakajima.

The discovery of XccOpgD and its role in CβG16α biosynthesis marks a major breakthrough in agriculture. It promises enhanced resilience and food security while mitigating environmental impacts linked to conventional pesticides. Overall, this advancement offers sustainable solutions to global agricultural challenges, promoting environmental stewardship and economic viability for farmers worldwide.

Leading the way in climate science: NTU’s breakthrough study on past warm periods

For millions of years, the Earth has experienced cyclical periods of ice ages and warm periods. Currently, we are in a warm period influenced by human activities. As greenhouse gases in the atmosphere increase, global warming intensifies, accelerating the melting of continental glaciers, raising sea levels, and posing serious climate crises to global ecosystems and human societies. To better understand the process and drivers of global warming, it is crucial to study the causes of past extreme warm periods, providing insights into present climate issues.

Geological records show that around 400,000 years ago, the global ice volume was less than today, and sea levels were about 10 meters higher. This warm period lasted approximately 30,000 years, making it the hottest warm period in Earth’s history over millions of years. Typically, summer solar radiation is the primary energy source for the Earth’s surface and a key driver of warm periods. However, during this period, solar radiation was relatively weak, and atmospheric greenhouse gas concentrations were lower than today, making this extreme warm period a famous mystery in Earth’s history, known as the “MIS 11c Paradox.” MIS stands for Marine Isotope Stage, used to describe the codes of alternating warm and ice periods in Earth’s geological history. The stages are numbered sequentially from the present, with odd numbers indicating warm periods and even numbers indicating ice periods. The Earth is currently in the MIS 1 warm period, while MIS 11c refers to the initial stage of the MIS 11 warm period about 420,000 years ago.

Dr. Hsun-Ming Hu, a postdoctoral researcher in NTU‘s Department of Geosciences, led an international team under the guidance of National Chair Professor Chuan-Chou (River) Shen. They utilized speleothem records from Mediterranean caves and North Atlantic marine records to reveal the key factors behind the anomalous warm period 400,000 years ago. This international research was published on July 15 in the top-tier journal Nature Communications.

Dr. Hu pointed out that solving the “MIS 11c Paradox” lies in understanding the response sequence of Earth’s ice shelves, oceans, and atmosphere to solar radiation during the warming process. However, due to the lack of precise absolute ages in most oceanic and terrestrial records, this issue remained unsolved. In 2014, NTU’s geoscience department and European partners drilled speleothem cores from the Witch Cave in northern Italy. Using high-precision uranium-thorium dating techniques from NTU’s HISPEC Laboratory, they analyzed the deposition time of the specimens, providing precise age control for geological records. Combining detailed carbon-oxygen isotope and trace element data, they reconstructed the environmental changes in southern Europe from 480,000 to 360,000 years ago. The team further compared solar radiation, global sea level changes, and climate records from various regions, including the Atlantic, finally unraveling the “MIS 11c Paradox.”

Professor Shen stated that the international team, led by NTU’s geoscience department, has been working in the Mediterranean region for over a decade. They discovered that the speleothem carbonate records from the Witch Cave in northern Italy are closely related to the climate changes in the Atlantic and Mediterranean. Therefore, the paleoclimate records of the North Atlantic region can be dated accurately by comparing them with the speleothem records from the Witch Cave.

The research results indicate that the extreme warmth during MIS 11c was caused by a combination of factors. About 420,000 years ago, summer solar radiation in the Northern Hemisphere increased, causing mid- and low-latitude Atlantic regions to reach peak temperatures. Coincidentally, as ocean warming occurred, Earth’s axial tilt gradually increased, leading to even hotter summers. These warm waters continuously transported large amounts of heat to higher latitudes through ocean currents over tens of thousands of years, causing sustained ice shelf melting and resulting in the hottest MIS 11c warm period in Earth’s history.

Dr. Hu further explained that MIS 11c is an important example for understanding global warming. Similar to the present, this period did not experience particularly strong solar radiation. The research team found that to cause widespread ice shelf collapse and significant sea-level rise in the Northern Hemisphere, high greenhouse gas concentrations are not necessarily required; prolonged ocean warming can achieve this. This reveals the critical role of oceanic forces in driving global warming and ice shelf collapse mechanisms, providing significant reference value for predicting Earth’s future climate.

This research was funded by the Ministry of Science and Technology’s Excellent Talent Program, the Ministry of Education’s Deep Cultivation Program, the Advanced Scientific Research Center for Sustainable Earth, and NTU’s Core Research Groups Program. The international project, led by NTU’s geoscience department, involved over twenty research units from Europe, the Americas, and Asia. NTU’s participating researchers included Dr. Hu, Professor Shen, and former students Hsien-Chen (Emerson) Tsai, Wei-Yi Chien, Wen-Hui (Ellen) Sung, and Chia-How Hsu.

Full research article: Nature Communications