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    One-step synthesis of pharmaceutical building blocks: New method for anti-Michael reaction

    The anti-Michael addition reaction, which involves nucleophilic addition reactions to the α-position of α,β-unsaturated carbonyl compounds, has been difficult to achieve so far. In...

    New insights into antihistamine binding could lead to more effective treatments

    Doxepin is an antihistaminic, antidepressant, and sleeping aid that has two geometric isomers—molecules with equal chemical formulas but different 3D arrangements. While its Z-isomer...

    Towards Cleaner Energy: Breakthrough in Anode Electrode Materials for Proton Conducting Solid Oxide Fuel Cells Operating at Medium Temperature

    Solid oxide fuel cells (SOFCs) are a promising avenue to meet global demands for clean energy. They can produce electricity through environmentally friendly electrochemical...

    Towards Next-Gen Functional Materials: Direct Observation of Electron Transfer in Solids

    Nanoscale electron transfer (ET) in solids is fundamental to the development of multifunctional materials. However, ET in solids is not yet clearly understood. Now,...

    Fighting Fat and Inflammation: Scientists Develop Powerful New Compounds

    Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is...

    Gut Bacteria Metabolite Shows Promise of Fighting Inflammatory Bowel Disease

    Gut bacteria convert dietary fatty acids into useful metabolites with benefits in metabolic and inflammatory disorders. However, their immunomodulatory effects and underlying molecular mechanisms...

    Breakthrough Rice Bran Nanoparticles Show Promise as Affordable, Targeted Anticancer Agent

    Plant-derived nanoparticles have demonstrated significant anticancer effects. Researchers from Japan recently developed rice bran-derived nanoparticles (rbNPs) that efficiently suppressed cell proliferation and induced programmed...

    Green-to-Red Transformation of Euglena gracilis Using Bonito Stock and Intense Red Light

    Euglena gracilis, often regarded as a “superfood,” is a promising microalga with many health and nutritional benefits. In a recent study, researchers from Japan...

    Rose essential oil: A safe pesticide for organic agriculture

    Researchers find that rose essential oil activates tomato defense genes and attracts herbivore predators that protect the plants. Following injury, plants release terpenoids to enhance...

    Flexible Artificial Intelligence Optoelectronic Sensors Towards Health Monitoring

    Artificial intelligence (AI) is known for its high energy consumption, especially in data-intensive tasks like health monitoring. To address this, researchers at Tokyo University...

    Uncovering Anxiety: Scientists Identify Causative Pathway and Potential Cures

    Quick-acting targeted therapies with minimal side effects are an urgent need for the treatment of anxiety-related disorders. While delta opioid receptor (DOP) agonists have...

    Scientists Achieve First Total Synthesis of Potentially Anti-Rheumatic Sesquiterpene Merillianin

    Merrillianin is a naturally occurring compound found in Chinese herbal medicine. In a significant milestone for drug development, researchers have succeeded in its artificial...