Thammasat University, Lampang Campus to cooperate with 53 government agencies, private sector

Thammasat University, Lampang Campus led by Assoc. Prof. Gasinee Witoonchart, Rector of Thammasat University, Assoc. Prof. Dr. Phipop Udon, Vice Rector for Academic Affairs, Assoc. Prof. Dr. Supreeya Kaewla-iad, Vice Rector for Lampang Campus Administration and Law along with the university administrators, faculty administrators, and faculty members, jointly discussed with the heads of government agencies, heads of both public and private agencies to find ways to develop academic cooperation between Thammasat University, Lampang Campus, government, and private agencies in order to join in the integration of knowledge and resources in various fields between government agencies and the private sector by building a network of partners to exchange academic knowledge which covers both research, academic activities, academic service to society collaboration on issues of interest according to the identity and prominence of the organization as well as cooperation in other fields that will benefit agencies, communities and society in a sustainable way.

In addition, Thammasat University and Lampang Provincial Administrative Organization also agreed to prepare a memorandum of understanding for collaboration in academic activities such as joint research, special lectures and international academic conferences, promote academic exchanges and cooperation that are beneficial to both sides. This memorandum of understanding will serve as a framework for cooperation to facilitate further discussion of specific project cooperation.

As Thammasat University, Lampang Campus is part of Lampang Province and the policy of the university focuses on developing people’s potential to be the driving force of the country’s economy. Thammasat University has designed the curriculum in parallel with the emphasis on the strengths of Lampang Province to strengthen people in the area and Lampang Province which will impact Thailand in the end. Thammasat University, Lampang Campus will be an important mechanism for human potential development to be the driving force of the country’s economy along with the development of local communities. This is a great way to promote Thailand’s economic development in the future.

Malaysia forges collaborative ties with Canada universities

In keeping with the aim of recognizing and establishing Universiti Teknologi MARA (UiTM) as a world class renowned University, a Memorandum of Understanding was signed between UiTM and the University of Ottawa, Canada. This was signed by the President of the University of Ottawa, President Jacques Fremont and the Vice Chancellor of UiTM, Prof. Datuk Ts. Dr. Hjh. Roziah Mohd Janor. This significant event was witnessed by Her Excellency, Datin Paduka Anizan Siti Hajjar Adnin, the Malaysian High Commissioner to Canada, at the Alex Trebek Alumni Hall at the university campus.

This effort was initiated by the UiTM Negeri Sembilan team, headed by the Rector, Prof. Dr. Yamin Yasin. The initial step was the signing of the Letter of Intent which was held on the 25th day of May, 2022 in UiTM, Shah Alam, Malaysia. Collaborative initiatives included various efforts in teaching collaboratively with lecturers involved at an international level. Apart from this, collaborations which focused on research and publication in the field of Engineering. Some of the outcomes of these involved the development and empowerment of the alumni and the community engagement within campus while encouraging collaborations via international competitions and placements for trainees. This event was not an isolated one but included the visit and preliminary discussions with other institutions of learning – George Brown College and the University of Carleton.

In her speech, the Vice Chancellor of UiTM fleshed out excerpts from the President’s previous speech during the LoI signing ceremony. She quoted the President “Signing an MoU is easy but the challenge is to achieve the objective that has been set out in the document”. These words have formed the very inspiration for UiTM with the full and complete support from the High Commissioner’s office. These individuals played important roles in facilitating the planning and making a reality, the travel journey of the Malaysian delegation over a time duration of 20 hours to reach their destination – Ottawa, Canada to sign an MoU that would stretch over a period of 3 years.

EdUHK research on resistance as form of resilience in sexual, gender minorities

Lesbian, gay, bisexual, and transgender (LGBT) individuals across the globe experience prejudice, discrimination, hate crimes, and many other forms of victimisation. As a fundamental means for transforming and advancing the conditions of LGBT individuals, collective action has gained increasing attention in research, policy and practice over the past decade. It has been used to advocate for LGBT rights, such as anti-discrimination laws, marriage equality, adoption and parenting, and legal recognition of gender. While collective action is influential in driving public awareness and policy changes, little is known about the psychological effects on individuals undertaking collective action.

The study by Dr Randolph Chan Chun-ho, Associate Professor at the Department of Special Education and Counselling, The Education University of Hong Kong, examined how different types of collective action moderate the negative relationship between perceived discrimination and mental health. The aims of the study were (1) to adopt an inductive approach to developing a scale for measuring collective action for LGBT rights in less democratic societies, (2) to examine the underlying dimensions of collective action for LGBT rights, (3) to investigate the moderating role of collective action on the relationship between perceived discrimination and mental health among LGBT individuals, and (4) to examine gender differences in the moderating effect of collective action.

The researchers developed a scale to measure collective action for LGBT rights and examined the underlying dimensions of collective action in a sample of 1,050 LGBT individuals in Hong Kong. The research also examined the moderating role of collective action on the relationship between perceived discrimination and depressive symptoms.

The LGBT Collective Action Scale measured two dimensions of collective action: private and public. The moderating effects of private and public collective action were significant, such that the positive association between perceived discrimination and depressive symptoms was weaker among LGBT individuals with higher levels of collective action. Subgroup analyses showed that private collective action moderated the association between perceived discrimination and depressive symptoms among sexual minority men and women, but the moderating effect of public collective action was found only in sexual minority women. Perceived discrimination was positively correlated with private and public collective action, but it exhibited a significantly stronger association with public collective action than with private collective action.

The study provided empirical support for the resilience effect of collective action in sexual and gender minorities. Collective action enables LGBT individuals to counteract heterosexism in various forms: either privately, by confronting the biased language and attitudes of others, or publicly, by taking part in protests for LGBT rights. Participating in private and public collective action can buffer the negative effect of discrimination on mental health in LGBT individuals.

The study was conducted together with Professor Winnie Mak Wing-sze at the Department of Psychology, The Chinese University of Hong Kong.

To learn more about the research, please click here.

Reducing the cost of cyber-attacks in higher education

The threat of cyber-attacks against universities has grown significantly in the past two years, as education went wholly online, costing, on average, almost half a million dollars in each instance. John O’Leary explores the problem.

Universities were already prime targets for cyber-attacks before the COVID-19 pandemic struck. The sheer volume of saleable data that institutions hold, from students’ bank account details to research findings of interest to companies and even national governments, made certain of that.

Their rapid switch to remote learning and the placing of more and more activities online, however, magnified the dangers. Security firm BlueVoyant estimated ransomware attacks on universities alone doubled between January 2019 and September 2020. The most common form of cyber-attack, ransomware, allows hackers to lock individuals or institutions out of their accounts until payment is made. Universities are naturally reticent about disclosing the size of such payouts, but the firm’s Cybersecurity in Higher Education report put the average at almost US$450,000.

Data breaches constitute the other main threat, with hackers exploiting the multiple entry points to university systems and often poor password management. Over a third of these were linked to learning tools and associated apps, according to BlueVoyant, which reports that credential lists are “massively trafficked” on the dark web.

For research universities, state-backed perpetrators are an additional danger. BlueVoyant found 200 such attacks over two years and suspects there were many more. Industrial and defence technology research tended to be the main targets, but medical and biotech data is of growing interest. Even one of the laboratories used for Oxford University’s world-famous COVID vaccine research was attacked in 2021. The university said it soon identified and contained the problem.While security around the most sensitive research projects can be effective, vulnerabilities elsewhere in university systems often provide an avenue for the most sophisticated operators. These types of attacks could result in the loss of competitive grants and place future patent royalties at risk. Reputational damage is as great a concern as immediate financial losses, especially when researchers or other staff are blamed for the breach.

Only in April, the Black Cat ransomware group claimed to have stolen more than a terabyte of data from Florida International University in Miami, and disrupted systems at North Carolina A&T State University. Later in the month, Austin Peay State University, in Tennessee, was forced to suspend final exams and close access to its computer labs while an attack was investigated.

Fitch, the American ratings agency, notes costly attacks have come at a time when many universities are already grappling with financial and operating stress related to the pandemic. Lincoln College, in Illinois, cited the costs of a ransomware attack as an additional reason for its closure in May. “All of our registration systems, our academic files, our finance, our admissions, our fundraising. It was all impacted and shut down,” said David Gerlach, the college president, in the aftermath. It took six weeks of negotiation to get the ransom down to “significantly less than US$100,000”, impacting student recruitment and delaying the start of the next semester.Cyber-attacks are by no means an exclusively American phenomenon. In the United Kingdom, for example, Northumbria University was forced to cancel exams and close its applications hotline during an attack in 2021, while neighbouring Newcastle University saw its IT systems disabled at around the same time. Dominic Raab, then the UK’s Foreign Secretary, told the Cyber UK conference that 80 British schools and universities were hit by ransomware attacks in March 2021 alone.

Andy Youell, a British IT consultant with 30 years experience in universities and national organisations, has seen the threat posed by cyber-attacks rise exponentially despite much-increased security, with university managers showing much greater concern about the dangers they pose. “The attacks have changed as universities have become ever more dependent on their IT systems. A lot of activity has moved to the Cloud, and that is probably a very good thing because those platforms are remarkably good at security,” he told The New York Times.

But Dr Youell fears that the characteristics of academics and students will always make some vulnerability likely. “Universities always find systems very difficult because there’s something inherent in a university that is about not staying on the tramlines. That mindset kicks against IT directors who want to follow rules.” Adding, “There are so many potential threats – from people who just want to create mischief, political or otherwise, and are usually relatively unsophisticated, to straightforward criminals and even foreign powers, who I have heard of doing all sorts of nefarious things. Most university systems are a lot more mature now, but there are plenty of incidents we never hear about.”

Universities are also struggling to match the salaries paid to highly-skilled IT staff in the private sector and to afford some of the more sophisticated equipment needed to update their systems successfully. However, the Ponemon Institute, in Michigan, puts the global cost of a data breach at almost US$4.26 million in 2021. It cites new ransomware trends, such as double extortion, where attackers do not return access to data and threaten to leak stolen data if a ransom is not paid, as a critical further risk.

Both the Federal Bureau of Investigation, in the United States, and the UK’s National Security Centre, have been closely involved in advising the higher education sector. In May, the FBI issued universities and colleges with a 10-point checklist after notifying them that “sensitive credential and network access information” was widely available on online criminal marketplaces. The advice included maintaining strong liaison with their local FBI field office, updating software, training students and staff to raise awareness of phishing, restricting access to accounts and credentials, closely monitoring remote desktop use, and using anomaly detection tools to identify increased traffic and failed authentication attempts.

“The exposure of usernames and passwords can lead to brute force credential stuffing computer network attacks, whereby attackers attempt logins across various internet sites or exploit them for subsequent cyber-attacks as criminal actors take advantage of users recycling the same credentials across multiple accounts, internet sites, and services,” the FBI advised. “If attackers are successful in compromising a victim account, they may attempt to drain the account of stored value, leverage or re-sell credit card numbers and other personally identifiable information, submit fraudulent transactions, exploit for other criminal activity against the account holder, or use for subsequent attacks against affiliated organizations.”

The National Security Centre (NSC) has issued its own advice, updated during the pandemic, calling for universities to implement a ‘defence in depth’ strategy, drawing up and testing an incident response plan, which includes a scenario for a ransomware attack. The NSC also encourages universities and colleges to sign up to its Early Warning Service, which uses a range of information feeds to notify organisations of malicious activity on submitted domains and IPs.

Many other countries have also stepped up their defences against cyber threats. Singapore, for example, has had a cybersecurity strategy since 2016 and updated it last year. The ASEAN region has now developed its own collaboration in this area.

Private security firms are also queuing up to offer advice to higher education institutions. Sion Lloyd-Jones, Senior Manager for Cyber, Information Protection and Business Resilience at KPMG, for example, offers cyber maturity assessments for universities and the appointment of a “red team” to mount a cyber-attack to expose vulnerabilities and test defences under realistic conditions, identifying weaknesses that may not previously have been obvious.

In the long run, there are hopes for improved forms of cyber security to lessen the risk of attacks. Hexham Courant reported in May that Cardiff University was developing a new tool that could automatically detect and destroy cyber-attacks on computers and other devices in under a second. Inverting the traditional antivirus approach of analysing what malware might look like, the new method considers how malware might behave. The results have been staggering so far. Over 90 percent of files have been prevented from corruption in an average of 0.3 seconds, according to the researchers.

In the immediate future, however, universities will continue to attract hackers with the volume of activity carried out online and the multiple points of entry to their systems. Although face-to-face learning and laboratory-based research have returned across most of the world, students, academics and many other staff still require remote access; often using devices and online practices that encourage vulnerability. While university security systems have improved, poorly funded, often understaffed IT departments struggle to hold the line. Training for students and staff is now commonplace and most institutions are conscious of the need to restrict access to sensitive information, but few institutions are fully confident of their ability to withstand a sophisticated cyber-attack.

This article was from the QS Global Education News Issue 09. Download the full edition.

UMY successfully breaks world record of most ‘wayang’ puppets played with puppeteers

One of the arts owned by Indonesia, namely wayang, should continue to be preserved as one of the nation’s cultural heritages. This was also the intention of Universitas Muhammadiyah Yogyakarta (UMY), who on its 2022 Ta’aruf Period (MATAF) held a puppet show and managed to break the world record as a puppet show with the most puppets and puppeteers. This record will be recorded by one of the world record-setting institutions, namely Record Holders Republic.

The event which took place on Sunday (4/9) was part of a series of MATAF events and took place at the UMY Sportorium. The wayang performance included main puppeteers and assistant puppeteers consisting of approximately 5700 new students in 2022 and involved a dialogue between the main puppeteers and all the assistant puppeteers. Also attending this event were Asia President of Record Holders Republic, Lia Mas Mutia Sari, who in her speech said that this event can be an inspiration and motivation for all students so that they can make achievements in world records.

The Vice Rector for Academic Affairs of UMY, Prof. Dr. Ir. Sukamta, ST, MT, IPM stated that this achievement can also be an inspiration for new students. “We want to inspire you, life begins with kindness and the courage to create achievements. And today you are invited to create UMY’s first achievement at the world level,” he said.

As part of the opening of the puppet show, there was a symbolic handover of the puppets to six new student representatives in 2022 from six regions, namely Sumatra, Java, Bali, Kalimantan, Papua and Sulawesi. The handover was carried out by representatives from the leadership of UMY, the Record Holders Republic, the Cultural Service of the Province of DI Yogyakarta and Bantul Regency and the Association of Indonesian Puppeters of the DI Yogyakarta Province. The process of playing the puppets was carried out for one hour and told about the destruction of civilization that was getting out of control, where new UMY students came to make changes for the country.

The wayang performance ended with the signing of the minutes by witnesses from the 2022 MATAF committee and the submission of a world record-breaking certificate from the Record Holders Republic which was received directly by the Vice Rector for Student, Alumni and Al-Islam Kemuhammadiyahan Affairs Faris Al-Fadhat, S.IP., MA, Ph.D.

Representing the Rector of UMY, he said that UMY was very grateful and proud of the new students for starting their activities at UMY with these two good deeds. “The first was to introduce culture through the world record with the most puppets and puppeteers, and the second was conveying a message to new students to excel from day one,” concluded Faris.

Commemorating 20 years of JICA, UPI partnership

Back in twenty years ago while national educational improvement in Indonesia was assisted by JICA through series of project including a building inaugurated by President Megawati Soekarno Putri and Ambassador of Japan Mr. Hideaki Domichi; Faculty of Mathematics and Science Education (FPMIPA) Universitas Pendidikan Indonesia commemorates this reflecting on experience of JICA cooperation in education, to share best practice in Indonesia and beyond, and to explore of driven status of lesson study development and partnership.

The committee chairman, Sumar Hendayana, said the FPMIPA Universitas Pendidikan Indonesia have been set up three activities since February 2022: (1) Faculty members training for enhancing science and mathematics learning through lesson study for learning community at FPMIPA Universitas Pendidikan Indonesia, (2) development of Memoar Essay book, there are 42 out of 52 articles lesson learnt of learning improvement with authors (nationwide, from Aceh to Papua), (3) JICA Reflective meeting (26 August 2022), along with launching of Asia-Africa Learning Improvement Network (AALIN), the 13th ICLS & 3rd ICLIm (27 August 2022), ALSI meeting (28 August 2022), dan open class at UPI-Labschool (29 August 2022).

About three hundred sixty-nine participants joined the event, which 93% of the participants participated online. Also, about Ninety-four presenter shared their papers include 5 keynote speakers, 12 plenary speakers, 3 symposium speakers, and 66 parallel speakers across from various background in education such as from teachers, principals, board of education, Ministry of education, students, and academicians both national dan internationally.

Prof Tatang Herman, Dean of FPMIPA Universitas Pendidikan Indonesia, explained the success of the 20 years commemoration of JICA cooperation in education is made possible by the supports of strong commitment of organizing committee members for their hard work over the last one year to provide interesting and stimulating the commemoration program for all participants.

Furthermore, JICA Indonesia Representatives, Mr. Kenji OKAMURA feels proud and happy and express JICA thanks-full on the 20th years of commemoration of cooperation between JICA-UPI, through a collaborative study of classroom-based learning that develop as a good practice that we called it as “Lesson Study”. He explained that this Japanese “lesson study” has been adopted in many collaborative education projects. JICA started its first technical collaboration aimed at improving the quality of basic education in the mid-1990s, responding to the global commitment to quality basic education, and Indonesia was one of the first five countries in basic education partnership emphasis on “ownership”, “partnership”, “independence” as the basic philosophy.

UiTM consolidates international connection with KJ Somaiya College of Arts, Commerce & Science via MoU

UiTM, via its branch campus, UiTM Kedah Branch, seeks to consolidate its connection with the institutions in India, this time with K.J. Somaiya College of Arts, Commerce & Science, Maharashtra, India. This linkage is cemented with the signing of the Memorandum of Understanding between both institutions on 14 July 2022. The signing was conducted via Gmeet at 2.30 pm. The signees are Professor Dr. Mohamad Abdullah Hemdi, the Rector of UiTM Kedah Branch (now retired), witnessed by Dr. Kamarudin Othman on behalf of UiTM; and Principal Dr. Birendra Singh Yadav, witnessed by Dr. Ravindra Ashok Jadhav on behalf of K.J. Somaiya College of Arts, Commerce & Science.

This MoU signing ceremony was made possible by the MoU project manager and coordinator for both institutions who are Puan Syazliyati Ibrahim from UiTM Kedah Branch and Dr. Ravindra Ashok Jadhav on behalf of K.J. Somaiya College of Arts, Commerce & Science respectively. The collaboration between both institutions started in September 2021 which the initial discussions regarding the online intercultural project named Window to the Bordeless World involving more than 300 students and 30 lecturers which started in November 2021 and ended in February 2022.

Professor Dr. Mohamad Abdullah Hemdi said in his speech that this MoU will enable both institutions to work together more closely towards the common goal which are the pursuit of internationalisation of education in both countries. Such a connection will also allow both institutions to establish the reputation in the international arena. Proposed future activities include institutional exchanges between faculty and staff from each partner institution; acceptance of undergraduate and graduate students of each partner institution for periods of study or research; organising of workshops, conferences, short courses, innovative competitions and meetings on research issues; and exchange of information pertaining to developments in teaching, student development and research institutions as agreed by the parties from time to time. Principal Dr. Birendra Singh Yadav also expressed similar sentiments in his speech and he was truly grateful for the efforts taken to formalise the linkage between both institutions.

This MoU signing marks the beginning of a solid collaboration between UiTM generally and UiTM Kedah Branch specifically with K.J. Somaiya College of Arts, Commerce & Science in numerous areas as stipulated in the document.

CCU’s College of Kinesiology and Health cultivates sports talents

The College of Kinesiology and Health (hereinafter referred to as CKH) inherited the traditional culture and spirit of Chinese Culture University (PCCU) for about six decades. CKH, one of the leading sports institutions in Taiwan, is committed to cultivating sports talents and high-level competitive sports and owns the foresight to demonstrate the spirit of the sustainable development of the Asian and Olympic Games.

CKH develops the largest ranges of sports teams, such as basketball, volleyball, baseball, soccer, rugby, korfball, tennis, soft tennis, Pétanque, badminton, table tennis, golf, bowling, wooden ball, gymnastics, rhythmic gymnastics, track and field, swimming, western rowing, dragon boat, archery, judo, wrestling, taekwondo, karate, boxing, Sanshou, pushing hands, Chinese martial arts (Wushu), Tai-Chi, dragon and lion dancing, fencing, jiu-jitsu, bodybuilder, qigong, mix martial art, etc. CKH awards scholarships and fee exemptions for elite athletes and representatives of Taiwan. Up till the present moment, CKH has trained the athletes not only to win hundreds of medals for Taiwan in international competitions but also to honor numerous trophies in national games.

The specialty of training plan brings together the different specific sports and academic programs arranged by all aspects of departments of Physical Education (from bachelor degrees to postgraduate Ph.D. level), Combat Sports and Chinese Martial Arts, and Exercise and Health Promotion. Our staffs and teachers are experts in their fields at the forefront of training trends. Meanwhile, the full-time teachers and invited coaches are responsible for coaching and managing.

For enhancing sports performance, CKH integrates all the resources of different scientific laboratories such as sports physiology, sports biomechanics, sports performance, sports psychology, athletic trainer, recovery, and rehabilitation to support the sports teams in various training fields: tactics and skill drills, strength training and physical conditioning, consultation, nutritional assessment, and athletic recovery, as well as rehabilitation, etc.

Under such aggressive challenge and pressure of recruiting athletes from sports-related departments in domestic universities, the College of Kinesiology and Health still insists a belief on the underlying goal of education: adopting the science-based and efficient training methods, monitoring the holistic status of athletes, reducing the risk of injury and improving performance, returning the health to athletes, and finally contributing and developing more superior coaches and athletes to Taiwan.

HKBU scientists develop versatile compound for treating Alzheimer’s disease

A study led by researchers from Hong Kong Baptist University (HKBU) has demonstrated that a multifunctional organic compound named F-SLOH has the potential to treat Alzheimer’s disease (AD) at an early stage. The team found that it can inhibit the aggregation of amyloid-beta (Aβ), and reduce the hyperphosphorylation of tau proteins and neuroinflammation in the brain to improve the pathological features of AD. The findings have been published in the international academic journal Redox Biology.

AD is the most common cause of dementia. It accounts for nearly 65% of dementia cases in elderly Hong Kong Chinese. It is pathologically characterised by the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerve cells in the brain, which cause progressive neuronal loss and cognitive impairment. Currently there is no cure for AD, and the available medicines can only relieve its symptoms. Inhibiting the abnormal aggregation of Aβ and the hyperphosphorylation of tau proteins is considered the primary and a promising therapeutic approach to treat AD.

F-SLOH as theragnostic agent for AD

In the search for novel therapeutic and diagnostic methods for AD, a research team comprising Professor Li Min, Professor of the Teaching and Research Division and Associate Dean of the School of Chinese Medicine; Professor Ricky Wong Man-shing, Professor of the Department of Chemistry of the Faculty of Science; and Dr Iyaswamy Ashok, Research Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine at HKBU, demonstrated the in vivo therapeutic efficacy of a compound called F-SLOH in reducing the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerves cells in the brain, thereby improving the learning and memory functions of mice with AD.

F-SLOH is a multi-functional cyanine probe synthesised by a team led by Professor Ricky Wong Man-shing for the detection of biological materials such as proteins and peptides. Its features include real-time visualisation of Aβ aggregation in brains, excellent permeability across the blood-brain barrier and low bio-toxicity. Previous studies showed that F-SLOH could inhibit the abnormal aggregation of Aβ species and provide neuroprotection against neurotoxicity induced by the abnormal aggregation of Aβ in vitro at the cellular level.

F-SLOH improves pathological features in AD mice

To determine the therapeutic efficacy of F-SLOH for AD, the researchers injected or fed F-SLOH to a group of transgenic AD mice. Histopathology and biochemical analyses showed that in mice treated with F-SLOH, Aβ oligomers (one of the Aβ species) and Aβ plaque deposits (the clumps of Aβ) were dramatically reduced in their hippocampus and their brains when compared with the AD mice in the control group who had not been fed F-SLOH.

The researchers also found that F-SLOH can reduce the levels of an amyloid precursor protein that generates Aβ and tau protein hyperphosphorylation. In an immunoblot analysis of the transgenic AD mice brian, the F-SLOH treatment group showed a significant reduction in the levels of the amyloid precursor protein and its metabolites compared to the control group.

In other experiments on the transgenic AD mice after F-SLOH treatment, the researchers separated the soluble and insoluble tau proteins in their brain tissue samples. The results showed that F-SLOH treatment significantly reduced the levels of insoluble tau protein in the brains of AD mice, which forms neurofibrillary tangles, one of the pathological features of AD.

F-SLOH improves memory and cognitive functions in AD mice

Aggregation of Aβ is closely related to the dysfunction of the links between nerve cells and memory decline. The researchers conducted two experiments to test the memory functions of AD mice. In the first experiment, mice were trained to swim in a water maze, reach a platform and remember its position. After the platform was removed, researchers observed whether the mice were able to recall and approach the original position of the platform. Compared to the control group, transgenic AD mice treated with F-SLOH spent more time swimming around the platform’s original position, showing that they can better memorise the platform’s location.

In the second experiment, mice were placed in a chamber and exposed to an audio tone followed by an instant small electric shock to their feet from the floor of the chamber. On the following day, they were put back in the chamber but without any electric shock. When the mice were exposed to the same audio tone, they “froze” their body movements due to the fear of an electric shock. The transgenic AD mice treated with F-SLOH exhibited a longer freezing time than that of the control group.

The results of the two experiments showed that AD mice treated with F-SLOH have better memories compared to the control group, suggesting that F-SLOH improved AD mice’s memory and cognitive functions.

F-SLOH shows early potential for treating AD

The researchers also revealed that F-SLOH degraded the abnormal aggregation of Aβ and reduced the levels of tau protein hyperphosphorylation, the amyloid precursor protein and its metabolites through the activation of the transcription factor EB. Transcription factor EB is the main regulator of the autophagy-lysosomal pathway, a major mechanism for degrading ageing intracellular macromolecular proteins, including the intracellular metabolites such as Aβ aggregates.

Professor Li Min said: “AD patients lose their self-management abilities and require long-term care as the disease progresses. As the population is ageing in Hong Kong, the prevalence of AD is likely to increase. There is an urgent need to develop new drugs that can treat or slow down the progression of AD. The current study suggests that the compound F-SLOH has promising theragnostic potential for treating AD at an early stage.”

Professor Ricky Wong Man-shing said: “The study provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. The research findings can drive advancements in AD diagnosis and treatment in humans.”

HKAPA’s School of Dance proudly launches Dance Well Classes at Artistic Spaces

The Jockey Club Dance Well Project is a creative movement programme designed for people with Parkinson’s disease and people of different ages and abilities through regular dance classes and activities in artistic spaces like galleries, museums and performance venues. Organised by our School of Dance and funded by The Hong Kong Jockey Club Charities Trust, this three-year Project will start the Dance Well Classes in September 2022.

Academy Director Professor Gillian Choa says, “One of the Academy’s main focuses has always been serving our community through engagement programmes of various performing art forms. We are delighted to lead this meaningful project, which aims to have a positive impact on the overall wellbeing of those with Parkinson’s disease, their families and close friends, and at the same time generate awareness of the disease in society. We are extremely grateful to the Hong Kong Jockey Club for its kind support of the project.”

The Project is modelled after the Dance Well initiative introduced in Italy by the Municipality of Bassano del Grappa and the Centro per la Scena Contemporanea in 2013. The practice has since been extended to other Italian cities and adopted by Tokyo, Kyoto and Kanazawa in Japan. HKAPA is introducing this approach to Hong Kong and invites local dance artists to collaborate to bring an inclusive dance experience to members of the public. A scientific research will also be led by our School of Dance to assess the practices and impacts of dance on the physical functioning, psychological and social wellbeing of people with Parkinson’s disease in Hong Kong throughout the project period.

Jockey Club Dance Well Project – Dance Well Classes Details (first 2 series):

Venue: JC Contemporary, Tai Kwun (10 Hollywood Road, Central, Hong Kong), Ben Brown Fine Arts (201, The Factory, 1 Yip Fat St, Wong Chuk Hang)

Date: Sep 30, 2022 to Nov 25, 2022 (Designated Wednesday & Friday)

Time: 9:45 am – 10:45 am

12 Sessions, Free Admission

Venue: Rehearsal Room, Xiqu Centre (88 Austin Road West, Tsim Sha Tsui, Kowloon)

Date: Nov 9, 2022 to Dec 30, 2022 (Designated Monday, Wednesday & Friday)

Time: 10:00 am – 11:00 am

12 Sessions, Free Admission

For details, please visit: https://jcdancewell.hkapa.edu/