Tag: Taiwan

The 2024 Commencement Ceremony for the College of Nursing at Taipei Medical University (TMU) was marked by a special celebration, featuring three esteemed winners of the 2024 College of Nursing Outstanding Alumni awards. These accomplished alumni shared their wisdom and experiences with the Class of 2024, offering valuable advice and inspiration as the graduates embark on their professional journeys.

This year, the College of Nursing at TMU has honored three outstanding alumni: President Shu-Fang Vivienne Wu, Dr. Cheryl Chia-Hui Chen, and Ms. Li-Yu Tang.

The awardee in the category of Management is President Wu, a 1995 graduate and the current President of National Taipei University of Nursing and Health Sciences, has been recognized for her exceptional contributions to the field. Her leadership and innovative approaches have significantly advanced the institution’s stature and operational excellence.

Meanwhile, Dr. Chen, a 1994 graduate and the Director of the School of Nursing at National Taiwan University, has been celebrated for her Academic Achievements. Her prolific research, published in top-tier journals and extensively cited, has made a substantial impact on the academic community and contributed to the advancement of nursing science.

The winner in the category of Social Service is Ms. Tang, a 1982 graduate and a consultant for the Taiwan Alzheimer’s Disease Association, has been acknowledged for her outstanding contributions to dementia care. Her work in advancing dementia care policies and enhancing Taiwan’s international standing in this area has been exemplary, reflecting her dedication and expertise in the field.

In a lively and engaging moderated session, the alumni discussed their personal definitions of success, emphasizing that success is multifaceted and often extends beyond professional achievements. They highlighted the importance of finding a balance between work and personal life, the significance of continuous learning, and the fulfillment that comes from making a positive impact on patients’ lives.

The session also delved into the alumni’s experiences with frustration and failure. They candidly shared stories of obstacles they faced throughout their careers, illustrating how these challenges ultimately shaped their paths and contributed to their growth. Their narratives underscored the importance of resilience, perseverance, and the ability to adapt and learn from setbacks.

As a highlight of the discussion, the alumni offered heartfelt advice to the new graduates. They encouraged the Class of 2024 to stay humble, remain curious, and continue learning.

The presence of these distinguished alumni and their invaluable insights added a meaningful dimension to the commencement ceremony, leaving the graduates inspired and ready to take on the challenges and opportunities of their careers. This event not only celebrated the achievements of the graduates but also highlighted TMU College of Nursing’s commitment to fostering excellence. The performance of its graduates and the recognition they receive from employers are key indicators of the university’s success.

In today’s digital age, there has been a noticeable shift in public awareness towards the importance of maintaining a healthy diet. More individuals are carefully examining the internet for information on the nutritional content of the good. However, this increased awareness possibly poses a challenge to people as the easy access to numerous conflicting nutritional advice and unchecked sources on the internet may steer them away from a healthy lifestyle.

Yen Nhi Hoang, from Taipei Medical University, School of Nutrition and Health Sciences, investigated the health information accuracy of the handy online AI tool “ChatGPT” with her team members, Jung-Su Chang and Dang Khanh Ngan Ho, among others. They compared the reliability of ChatGPT-3.5 and ChatGPT-4 in providing information on calorie and macronutrients, including carbohydrates, fats, and proteins.

The research identified minimal differences between nutritionist and AI estimations of energy, carbohydrate, and fat contents. Notably, there was a significant divis ion in protein estimation. Both chatbots accurately provided energy contents for approximately 35% to 48% of the 222 food items within ±10%, with a caffeine variation of less than 10%. It was observed that ChatGPT-4 outperformed in this aspect.

Their research results showed that AI can undoubtedly be a useful and convenient tool for acquiring energy and macronutrient information. However, limitations include the AI having a knowledge cutoff of September 2021. In an interview with Nutrition Insight, Dr. Jung-Su Chang cautioned about the existence of “AI hallucination.” Depending on different chatroom environments, such as types of input language and clarity of the prompt, AI may provide convincing information that is factually incorrect. Chang also pointed out that it’s hard for average people to tell the reliability of the information the chatbot provided.

“Currently, the capability of AI chatbots to provide personalized dietary advice, such as specific nutrition guidelines and exact portion sizes, is limited.” the research team warned.

Despite this current limitation, AI chatbots could be a handy tool for nutritionists to quickly access nutrition information. Nonetheless, it’s remains challenging for AI chatbots to function independently as nutritionists.

Supported by the National Research Council provided through integrated project funding, Professor Shih-Min Hsia’s research team at the School of Nutrition and Health Sciences of Taipei Medical University has found a potential relationship between long-term exposure to the non-nutritive sweetener acesulfame potassium and uterine hypercontraction, particularly those induced by oxytocin, and reported the discovery in Molecular Nutrition and Food Research. In the study, it was demonstrated that an excessive intake of non-nutritive sweeteners containing acesulfame potassium may cause uterine hypercontraction and increase preterm risk, suggesting that pregnant women should avoid long-term consumption of processed foods containing artificial sweeteners.

Along with the development of the food industry, the demand for sugar has been gradually increasing. Due to their high level of sweetness and low cost, non-nutritive sweeteners are often used in the food industry as food additives. Previous studies have shown the consumption of non-nutritive sweeteners to be associated with a 1.2-fold increase in preterm births and a reduction in the gestational period by 0.11 weeks, but the effect of acesulfame potassium exposure on uterine contraction in pregnant women has not yet been studied.

Uterine hypercontraction is significantly triggered by the influx of calcium ions or oxytocin signaling pathway, which causes the contraction of uterine muscle bundles. The medical conditions caused by uterine hypercontraction include preterm labor risk, endometriosis, and menstrual pain, and consequent inflammatory responses can result in the secretion of cytokines and the aggravation of oxidative stress, which may lead to menstrual discomfort and a deterioration in life quality for women.

In the study, it was revealed that exposure to acesulfame potassium caused an upsurge in the concentration of calcium ions in uterine smooth muscle cells and calcium ion influx, which resulted in an increase in uterine contractions. In a long-term exposure experiment, the subjects were fed daily with an amount of acesulfame potassium equivalent to that contained in two cans of Coca-Cola Zero, as well as a tolerable daily intake via oral gavage for 8 weeks. The results showed that acesulfame potassium increased intrauterine pressure and oxytocin-induced contractions. In a further clinical collaboration, it was found in a cohort study that pregnant women with higher exposure to acesulfame potassium had a higher risk of preterm birth.

This study was the first to investigate the influence of non-nutritive sweeteners on pregnant women and confirm their effect on uterine hypercontraction with scientific evidence, alerting people with their life quality affected by uterine hypercontraction, such as those with menstrual pain, endometriosis, and pregnancy to the risk of long- term consumption of non-nutritive sweeteners.

The World Health Organization (WHO) declared that the vast majority of hepatitis patients worldwide do not have access to timely hepatitis detection and treatment. Sadly, the condition of millions of hepatitis patients is at risk of worsening into cirrhosis, liver cancer, and death. Hepatitis also strongly impacts us, as it is the leading cause of death among Taiwanese. Furthermore, liver cancer has been ranked among the top 2 causes of death for the last 40 years.

Reluctantly tacking these problems, Chair Prof. Oliver Hu (Hu Yao-pu), alongside his research this research team from the Taipei Medical University, Academia Sinica, and National Defense Medical Center, in collaboration with international biomedical companies Avalon HepaPOC Limited and Jaco Biotech, successfully developed the “GSP (Galactose Single Point) Rapid Measurement System.” This system facilitates instant and quantitative measurement of the blood flow and enzymes of the liver using a single-point blood test to determine actual liver function.

To save us time and alleviate pain, the GSP Rapid Measurement System was created to use the GSP (Galactose Single Point). We are proud to announce, this method invented by Prof. Hu can be employed immediately in a clinical setting. The Method has been recommended in the guidelines promulgated by the U.S. Food and Drug Administration (USFDA) and Taiwan’s Ministry of Health and Welfare. Apart from that, GSP is also included in widely used medical textbooks in the U.K. and the U.S. In May 2022, it was also published in “Analytical and Bioanalytical Chemistry.” a world-leading biomedical analytical journal that’s existed for over 100 years.
(https://link.springer.com/article/10.1007/s00216-022-04051-1)

This measurement system allows rapid quantification of the degree of liver impairment in patients. It can be applied to a wide range of patients with liver insufficiency by adjusting the dose of medications such as phenytoin, statins, and cefoperazone. Moreover, GSP also facilitates the screening for congenital galactosemia for the timely and cost-effective clinical management of patients.

Prof. Hu highlighted that the GSP Rapid Measurement System can be used in hospitals, clinics, and even pharmacies to test liver functioning. The actual liver function results are available within an hour. The simple measurement method is similar to blood glucose testing: patients just have to draw a little blood an hour after drinking or injecting galactose, and their liver function can be tested within 75 seconds. Currently, the System is patented in Taiwan, the U.S., China, and other countries, and was granted an In Vitro Diagnostic Device (IVD) license by the Ministry of Health and Welfare of Taiwan. It is expected to serve and benefit a large number of patients diagnosed with liver disease as well as those taking physical examinations.

In addition to prolonging lifespan, scientists also have long been in pursuit of maintaining human healthspan. For the elderly, as their declined muscle mass and strength cause physical inconvenience, maintaining the health of skeletal muscle is therefore of vital importance so as to keep the ideal quality of life.

Professor Yi-Fan Chen and Professor Yun Yen from Taipei Medical University, in collaboration with researchers from Japan and Taiwan, have recently published their work in npj regenerative medicine. The research article examines how Ribonucleotide reductase M2B (Rrm2b) modulates the fate of stem cells in skeletal muscle in response to injury. The homeostasis of skeletal muscle relies on the interplay between the muscle stem cells (MuSCs) and their microenvironment (niche). By genetically modified mouse models, Chen unveiled that specific knockout of Rrm2b in the myofibers (a part of niche), but not in MuSCs, led to the weakness of muscles, including loss of muscle mass and strength. These Rrm2b myofiber-specific knockout mice displayed compromised regenerative capacity of muscle with thinner fiber sizes and weaker functioning. Moreover, the lack of Rrm2b in the myofibers resulted in mitochondrial defects, showing a part of the typical characteristics of mitochondrial myopathy.

Furthermore, Chen’s team collaborated with Dr. I-Hsuan Lin, her fellow TMU researcher, for RNA-sequencing to identify several myokines released from Rrm2b-deleted myofibers. These myokines, including FGF-21, GDF-15, and Mthfd2, triggered MuSCs differentiation rather than reentry of quiescence to repopulate the stem cell pool. The decreased MuSC pool due to the imbalance between differentiation and self-renewal of MuSCs thus contributed to muscle weakness and impaired regenerative capacity.

In conclusion, Chen’s study identified a novel role of Rrm2b in muscle homeostasis. Rrm2b in the myofibers plays a critical role in modulating the stem cell fate of MuSCs by an alternation of the microenvironment (niche), and it provides an opportunity for strategy development to treat muscle disorders. Animals with defective Rrm2b expression can probably serve as a disease model for investigating mitochondrial myopathy in mammals. It is expected that such promising research findings will lead to clinical use in promoting muscle health in the coming years.

DOI: https://doi.org/10.1038/s41536-022-00231-w