38 EdUHK Scholars Named World’s Top 2% Scientists by Stanford University

Thirty-eight scholars of The Education University of Hong Kong (EdUHK) were named among the top 2% most-cited scientists in the world, in the latest annual rankings published by Stanford University, as of October 2023.

Among them were new President Professor John Lee Chi-Kin, who assumed the position last month; Vice President (Research and Development) Professor Chetwyn Chan Che-hin; Advisor and Adjunct Chair Professor (Geography & Environmental Science) Professor Jim Chi-yung, Advisor (Environmental Science) Professor Wong Ming-hung; and Professor Rudolf Wu Shiu-sun, who has invented ‘artificial mussels’, an effective tool that can monitor radioactive contamination in waters around the world.

Compiled by a research team at Stanford University, the rankings list top scientists from a wide range of fields, based on their career-long citation impact or single-year citation impact in 2022.

EdUHK scholars fared well in their respective fields. Notably, Professor Jim Chi-yung, also known as ‘Dr Tree’, ranked first out of over 30,000 scholars in the field of forestry, representing the high citation rate and significant impact of his research output. Professor Wong Ming-hung from the Department of Science and Environmental Studies also ranked 8th out of nearly 100,000 scholars in environmental sciences.

In addition to research capacity and impact, the University has also secured record-high funding of over HK$27 million under the annual Research Grants Council’s General Research Fund and Early Career Scheme. Once again, EdUHK came first, in the discipline of education, both in terms of the number of funded projects and amount awarded. The University has also made significant strides in various disciplines, such as psychology and linguistics, further underscoring its solid foundation in broadening academic scope beyond education.

Congratulating the EdUHK team, President Professor Lee said, “The University has made great strides in research in education and various emerging disciplines, as illustrated by its remarkable achievements over the years. To further extend our research impact in Hong Kong and beyond, we have established two new Academies, namely the Academy for Educational Development and Innovation and the Academy for Applied Policy Studies and Education to better promote interdisciplinary research with greater synergy.”

Learn more: https://www.eduhk.hk/en/features/38-eduhk-scholars-named-world-s-top-2-scientists-by-stanford-university

EdUHK Research on Understanding Chinese Mathematics Teaching

Past research on Chinese mathematics teaching has focused mainly on the role of teacher’s beliefs and professional knowledge separately in teaching approaches, or examined three variables – teacher’s beliefs, professional knowledge and teaching approaches – in correlational studies. How teaching beliefs and professional knowledge specifically influence teaching approaches remained largely unclear. Also, most studies have focused on pre-service or elementary school teachers in the West. There is a need to know whether these conceptual frameworks can be applied and adapted to the Chinese teaching context at the secondary level.

Dr Zhang Qiaoping, Assistant Professor at the Department of Mathematics and Information Technology, The Education University of Hong Kong, conducted a study to help fill this research gap by investigating (1) what kind of mathematical knowledge of functions and beliefs mathematics teachers in secondary schools in mainland China have, and (2) how their professional knowledge and beliefs about mathematics affect their teaching approaches.

Phase 1 of the study was a questionnaire given to 92 mathematics teachers to get a picture of their beliefs about mathematics, along with their subject matter knowledge (SMK) and pedagogical content knowledge (PCK) regarding the concept of functions.

In Phase 2, based on the responses in Phase 1, six teachers were selected from three districts to participate in a case study, which examined the teachers’ beliefs about mathematics in terms of their beliefs about the nature of mathematics, mathematics teaching and mathematics learning. The study found that three main beliefs held by the teachers were instrumentalist, Platonist, and problem-solving-oriented.

Regarding the nature of mathematics, over 70% of teachers believed that mathematics is a collection of rules and steps for solving problems. Most teachers believed that learning mathematics was about both getting answers quickly and understanding why solutions were correct. Over 60% of teachers believed that they should cover all topics in the logical order presented in textbooks, and 70% agreed that teaching activities should be challenging for students.

Teachers with weak PCK lacked variation in their teaching methods, while teachers with stronger PCK used textbooks flexibly according to their students’ needs. Their teaching designs were based on practical considerations, and they used many metaphors and analogies to explain concepts.

As for problem-solving, teachers with rich PCK gave counter-examples based on students’ mistakes to deepen their overall understanding; and they encouraged students to engage in classroom activities, allowing them to present their ideas and explore new knowledge.

The teachers’ professional knowledge scores were relatively high for familiar, everyday teaching questions, but very low on questions about unfamiliar functions.

The study concluded that there is a need to emphasise the integration of teachers’ professional knowledge with their mathematical beliefs, and that it is important to know what beliefs teachers hold about both the nature of mathematics and mathematics teaching, and how these beliefs influence their teaching.

HKAPA Signs MOU with Department of Training of The Ministry of Culture, Sports and Tourism of Vietnam

The Hong Kong Academy for Performing Arts (HKAPA) announced on 19th September the signing of a Memorandum of Understanding (MOU) with the Department of Training of the Ministry of Culture, Sports and Tourism of The Socialist Republic of Vietnam (Department of Training) to promote educational exchange in arts and culture between Vietnam and the Academy.

The Academy is honoured to welcome a delegation of 22 people, led by H.E. Mr. Pham Binh Dam, Consul-General of Vietnam in Hong Kong, and Associate Professor Dr. Le Anh Tuan, Director General of the Department of Training of Vietnam.

The MOU was signed by Associate Professor Dr. Le Anh Tuan, Director General of the Department of Training of Vietnam, and Professor Gillian Choa, Director of HKAPA. Witnessing the signing of the MOU were Professor Douglas So, Acting Council Chairman of HKAPA, and ​H.E. Mr. Pham Binh Dam, Consul-General of Vietnam in Hong Kong.

The MOU outlines the principles and scope of collaboration, aiming to enhance professional knowledge and skills in the performing arts sector in Vietnam. Under the MOU, selected Vietnamese students will participate in education and training programmes organised by HKAPA. Cooperation and cultural exchange activities between HKAPA and the training institutions under the Ministry of Culture, Sports and Tourism of Vietnam will be encouraged.

Professor Douglas So, Acting Council Chairman of HKAPA, welcomes the collaboration, stating, “The signing of the MOU today signifies our commitment to fostering closer ties between the Academy and Vietnam in the field of performing arts education. Through this collaboration, we envision a wide range of arts and cultural activities that will strengthen our artistic communities. By joining hands with the Department of Training of the Ministry of Culture, Sports and Tourism of Vietnam, we look forward to creating meaningful opportunities for artistic exchanges, talent development, and collaborative projects in Asian performing arts.”

EdUHK Research on Bidirectional Relations of Word Reading to Timed Visual Tasks in Chinese

Most research on the association between visual skills and reading has focused on how visual skills facilitate reading. But learning to read Chinese involves both visual skills and mapping between print and sound. It is not clear how their association develops in later stages. This study investigated the association of timed visual processing tasks varying in levels of phonological processing with word reading.

Dr Melody Pan Jinger, Assistant Professor at the Department of Psychology, The Education University of Hong Kong, and her research team included in their study (1) Cross Out, a speeded task that involves visual processing of nonalphanumeric stimuli; (2) Visual Matching, a speeded task which involves visual processing of numeric stimuli; and (3) numeric Rapid Automatised Naming, a speeded task which requires visual processing and oral output. Stimuli used in the Cross Out task are not verbally codable, whereas those used in the Visual Matching and Rapid Automatised Naming tasks are. Visual Matching does not require verbal output, while Rapid Automatised Naming does. These differences allowed us to investigate how phonological processing modulates the relationship between speeded visual processing and word reading.

The study tested 293 Chinese children on nonverbal IQ at age 4, phonological and morphological awareness at age 5, Cross Out and Visual Matching at ages 6 to 8, and Rapid Automatised Naming and Character Recognition at ages 5 to 9 to measure their reading accuracy.

The results found that children’s Character Recognition at ages 6 and 7 predicted Cross Out at ages 7 and 8. There was a cross-lagged relationship between Character Recognition and Visual Matching from ages 6 to 7, but Character Recognition at age 7 significantly predicted Visual Matching from age 7 to 8. Rapid Automatised Naming and Character Recognition predicted each other from ages 5 to 6, but only Rapid Automatised Naming predicted subsequent Character Recognition from ages 6 to 9.

Learning to read Chinese requires substantial visual processing. However, the findings of the study also highlighted the importance of reading skill for the development of children’s visual skills, irrespective of the type of visual stimuli.

The results extended previous findings by showing that visual processing can be improved by learning to read. It also suggested that the reciprocal relationship between visual processing and reading depends on the age and the type of stimuli of the visual processing task.

The findings reflected the development of reading Chinese. In the logographic stage, children tend to recognise characters based mostly on their visual features. Recognising Chinese characters, which are far more complex than the alphabet, helps children develop their visual skills. But in the cipher phase, children need to rely on decoding. Though Chinese is an opaque script, children still rely on phonological information in the early years of primary school. The association between visual codes and phonological codes, as reflected in Rapid Automatised Naming and in later ages in the Visual Matching task, are important for Chinese children in learning to read.

The study concluded that the relationship between Chinese character recognition and tasks involving speeded visual processing differ largely depending on age and whether alphanumeric stimuli and phonological processing are involved. Learning to read Chinese appears to facilitate early two-dimensional, geometric, pure (non-print-related) visual processing, but visual processing appears to promote subsequent reading of Chinese only when it involves alphanumeric print. This pattern is likely attributable in part to the development and specialisation of print recognition over time and partly to the involvement of explicit phonological coding in the process.

The study was conducted together with Dr Cui Xin and Professor Shu Hua from Beijing Normal University, and Professor Catherine McBride from The Chinese University of Hong Kong.

To learn more about the study, please click here.

Lingnan University’s vision for the future of the liberal arts

Lingnan University (Lingnan) is the innovative home of the liberal arts in Hong Kong. As part of Times Higher Education’s Connect Research Stories series, six of Lingnan’s leading figures described how the university is building on both its traditional values, and the possibilities of digital technology, to create exciting pathways for both staff and students.

“We are in a great position to venture and lead with our liberal arts education model,” noted Lingnan President Professor S. Joe Qin. This model, he said, is based on whole-person education, or boya in Chinese. Given Hong Kong’s status as a world city, Prof Qin wants to see Lingnan at the forefront of the merging of Eastern and Western aspects of liberal arts education.

Pun Ngai is chair professor, and head, of the Department of Cultural Studies at Lingnan. “Students come to cultural studies because they would like to pursue creativity,” she explained. “Through cultural commons, through social innovation, through creativity, we can really generate different forms of community projects.”

Prof Pun’s department created its i-COMMON platform to connect with more than 30 community partners engaged in activities such as social enterprises and organic farming.

Lingnan’s Science Unit also values collaboration with local communities, as well as its interaction with faculty from other disciplines. “It’s important to us to show that we’re doing something of worth,” said the Science Unit’s Professor Jonathan Fong.

Prof Fong explained that when conducting research – for example, into changes in Hong Kong’s air pollution – it was necessary to ask, ‘What does this mean to the general public?’, and can the work be used to influence public policy and make a positive impact on society.

William Hayward, chair professor of psychology and dean, Faculty of Social Sciences, pointed out that his faculty actively engage with not only Lingnan’s many international partners, but also with the surrounding community in Hong Kong’s socially deprived North West New Territories.

The possibilities of digital technology and data science offer new tools for this work, Prof Hayward said. “And that requires us to be interdisciplinary, to work with data scientists and to bring people in who have expertise in AI, social computation, and so forth.”

Professor William Liu Guanglin, of Lingnan’s Department of History, grew up on the Mainland as Deng Xiaoping’s economic reforms were transforming China, and this experience, he said, has shaped his outlook.

“Economic history is basically an interdisciplinary subject between history and economics,” Prof Liu explained. He added that it is both fascinating and challenging to reconcile the very different methodologies used in each subject.

Yau Yung is a professor of urban studies in Lingnan’s School of Graduate Studies. As an example of the ways in which his team aims to create real-world impact and help realise a more sustainable future, Professor Yau cited its work to help end unsafe and inadequate housing in Hong Kong.

“The city’s poorest have no choice but living in subdivided flats.” These are tiny, many have no natural light, and sometimes cooking, toilet and sleeping spaces are all in the same cubicle.

Please click here to view the video series.

EdUHK Research on Developing and Validating a Student Feedback Literacy Scale

Although the importance of investigating the enabling role of student feedback literacy has been widely covered in the literature, a measurement instrument is still lacking. A study by Dr Jane Zhan Ying, Assistant Professor at the Department of Curriculum and Instruction, The Education University of Hong Kong, used a construct validation approach to validate the self-developed student feedback literacy scale, with two types of examinations: within- and between-network examinations. Within-network examinations use reliability and confirmatory factor analyses (CFAs) to explore the dimensional structure of the scale. Between-network examination performs correlation analyses to investigate the correlation between the scale and other constructs theoretically related to the scale.

Previous research has found that at the very beginning of the feedback process, students must actively elicit feedback from others; comprehend the feedback received, judge its quality and extract information to enable subsequent action; and take actions to revise their work. Feedback can help them better understand their learning by identifying their learning strengths and weaknesses from the perspectives of others, learning from others, and enhancing their self-reflection. They must be emotionally ready to engage with feedback (readiness to engage). And they must devote their time and effort to making changes in their learning and strive to continuously improve by conquering difficulties and finding extra support or resources. Based on the literature review, the author constructed six dimensions of student feedback literacy: three related to the students’ capacity to elicit, process and enact feedback; and three related to the students’ disposition in terms of appreciation of feedback, readiness to engage and commitment to change.

In this study, the author issued the developed 24-item student feedback literacy questionnaire to 555 university student participants in mainland China to validate the scale. Both confirmatory factor analysis and multi-group confirmatory factor analysis showed that the scale was valid and that its structure was stable among students of different genders and in different majors. The between-network analysis presented a significant correlation between the six dimensions of student feedback literacy and students’ intrinsic and extrinsic learning motivation.

Future studies could use the validated scale in this study to capture its temporal changes or explore the complex relationships between student feedback literacy and its influencing factors. It will enable higher-education teachers to systematically analyse student feedback literacy, such as the critical development period and possibly unbalanced development. This will help teachers reflect on their current feedback practices to see whether they create conditions conducive to the development of targeted aspects of student feedback literacy and what measures they can apply to facilitate its development.

Lingnan’s President lands major international award

For Professor S. Joe Qin, the new President of Lingnan University in Hong Kong, there was a special reason to attend the recent high-profile event organised by the IEEE (Institute of Electrical and Electronics Engineers).

He had been invited to receive the IEEE CSS (Control Systems Society) Transition to Practice Award, a prestigious honour which recognises outstanding collaborative scientific interactions between industry, research laboratories and the academic community.

This year’s presentation ceremony took place during the 7th IEEE Conference on Control Technology and Applications (CCTA), held in Barbados in mid-August.

And in becoming the first academic based in Hong Kong and Greater China to pick up this top international award, presented annually since 2009, Qin joined a distinguished list of previous recipients that includes leading figures in the United States, Canada and Japan.

The IEEE is the world’s largest technical professional organisation with a stated mission of advancing technology for the benefit of humanity.

In selecting Qin, they made special mention of research he conducted when based at universities in the US, and how it had helped to resolve practical problems faced by the chemicals and semiconductor sectors, thereby improving manufacturing and production processes.

The committee also noted his breakthrough contributions in the area of data-driven control engineering. And they noted his successes in promoting methodological advances and knowledge transfer in systems safety, health monitoring and diagnosis.

“Receiving the award means a lot to me because it is for people who have done good original research and seen it transition into practice,” Qin said. “That is the kind of work I always wanted to do. I’ve generally picked research topics that have good potential for application and, for the past 25 years, have focused on new technologies and what can be learned from data analytics.”

In particular, he took an early interest in “model predictive control”, which was an accepted practice in industry. He and co-author Dr. Thomas Badgwell were the first to provide a unified framework to reveal the principles of industrial practice. Using abundant data from operational control systems at AMD (Advanced Micro Devices), Qin co-authored another paper that studied how manufacturing conditions usually change over time, with some causing faults and disruptions, and devised an adaptive algorithm to detect faults.

“We were lucky enough to discover and define what was happening, come up with a framework and put it into practice,” he said. “We made some later adjustments, but [the work] is now considered a milestone in that domain.”

Significantly, the resulting paper has since received more than 6,000 citations on Google, and the project continues to stand out as a prime example of how academic research can have a lasting impact on industry.

In a plenary speech at the IEEE conference, Qin reflected on other career highlights and spoke about a new framework for dynamic latent variable (DLV) analytics.

He also stressed the need for greater domain knowledge in machine learning and data analytics, plus the importance of using innovations in technology to address real-world issues.

How vocabulary breadth and depth influence bilingual reading comprehension

Numerous studies highlight vocabulary as a critical predictor determining word and text reading comprehension in monolingual and bilingual children, but when measuring vocabulary, most studies focus on either breadth or depth, or conflate the two, which devalues the unique role each dimension plays in reading comprehension.

A study by Dr Tong Xiuhong, Assistant Professor at the Department of Psychology, The Education University of Hong Kong, examined the links between breadth and depth of vocabulary knowledge and reading comprehension, and the mediating impact of word reading on these links within and across first language (L1) Chinese and second language (L2) English among 391 Chinese-English bilingual second graders in Hong Kong mainstream primary schools where Chinese is the medium of instruction and English is taught as L2.

Parents and caregivers filled out a questionnaire on family demographics, children’s language background, and home language use, with four questions: the language the child prefers (1) when speaking with parents, (2) when watching TV/videos, and (3) when reading books and magazines; and (4) the main language parents use to speak with their children.

To measure vocabulary breadth and depth, parallel measures of L1 Chinese and L2 English vocabulary were administered. For L1, Chinese receptive vocabulary breadth, and expressive vocabulary breadth and depth were measured. For L2, English receptive vocabulary breadth and expressive vocabulary depth were measured.

To measure reading, parallel measures of L1 Chinese and L2 English word reading and reading comprehension were administered to all participants.

Control measures included assessing children’s nonverbal reasoning ability, L1 Chinese phonological awareness and L2 English phonological awareness.

The study demonstrated the occurrence of a cross-language association between L1 Chinese vocabulary and L2 English reading comprehension, and revealed different ways in which L1 receptive vocabulary breadth and depth contributed to L2 reading comprehension.

The findings extend contemporary models of reading comprehension to include bilingual readers and suggest that one theoretical framework assuming either a direct or indirect effect on vocabulary cannot adequately explain the complexity and specificity of the relation between oral vocabulary and reading comprehension.

Moreover, by highlighting the mediating role of word reading in the link between vocabulary and reading comprehension within and across languages, the findings reinforce the non-selective view of the lexical access of bilinguals and underscore the interaction between L1 and L2 lexicons in reading comprehension.

The findings have educational implications for biliteracy practices. First, since quantity and quality of vocabulary affect L1 Chinese and L2 English reading comprehension, biliteracy programs may consider targeting both to increase L1 and L2 lexical richness. Second, the facilitative effect of L1 Chinese vocabulary on L2 English reading comprehension suggests that biliteracy teaching and intervention programs should utilise L1 language skills to scaffold the acquisition of L2 vocabulary and reading comprehension.

Past studies have shown that providing bilingual versions or side-by-side translations of texts can improve bilingual children’s literacy development. Thus, when reading and writing, bilingual students should be encouraged to use their L1 and L2 language repertoires to think, reason, imagine, and organise ideas.

The study was conducted together with Dr Shelly Tong Xiuli, Associate Professor in the Department of Human Communication, Development, and Information Sciences at The University of Hong Kong.

HKAPA, Swire orchestrate inclusion through Greater Bay Area Youth Orchestra Debut Concert

Established and directed by The Hong Kong Academy for Performing Arts (HKAPA) with the support of the Swire Group as Founding Patron, the Greater Bay Area Youth Orchestra (GBAYO) made its debut on 11 August at the Hong Kong Jockey Club Amphitheatre of the HKAPA, kicking off its four-city tour in the GBA. Officiating guests included Mr. Liu Guangyuan, Deputy Director of the Liaison Office of the Central People’s Government in the Hong Kong SAR; Prof. Douglas So Cheung-tak, BBS JP, Acting Council Chairman of HKAPA; Ms. Michelle Li, Permanent Secretary for Education of the HKSAR; Prof. Gillian Choa, Director of HKAPA; Mr. Merlin Swire, Chief Executive Officer of John Swire & Sons Limited and Mr. Guy Bradley, Chairman of Swire Pacific Limited. RTHK Radio 4 will arrange a delayed broadcast of the Debut Concert at 8 pm on 14 August 2023 to share the joy of music with the public at large. The young musicians from Guangdong, Hong Kong, and Macau departed the next day for their second concert at the Macau Tower.

GBAYO is the first dedicated initiative for young musicians in the region by HKAPA. It aims to enhance interaction among young talents in the GBA and encourages cultural exchange. Following the first two concerts in Hong Kong and Macau, the youth orchestra will continue to put together delightful evenings of musical performances for audiences at the Shenzhen Grand Theatre and Guangzhou Xinghai Concert Hall.

An unparalleled cultural and artistic exchange platform in the GBA

GBAYO was established in July 2022 by HKAPA, in partnership with the Xinghai Conservatory of Music and the Macao Youth Symphony Orchestra Association, supported by Swire Group as the Founding Patron. It strives to be one of the top youth orchestras globally with the vision of elevating the musical standard in the region while establishing an internationally recognised platform for classical orchestral performances.

The orchestra began recruitment for its inaugural training camp and concert tour in February, inviting young orchestral musicians aged 16 to 24 who were either born, graduated, currently living, studying, or working in the GBA to enroll. The GBAYO was thrilled to welcome 88 young musicians from the GBA. They participated in a training camp from 31 July to 11 August at HKAPA in Hong Kong and received around 60 hours of training from 13 renowned instructors.

“We are honoured to host the meaningful GBAYO Debut Concert at HKAPA, where the artistic direction and the educational part of the programme are presented by the School of Music. My most sincere gratitude to everyone involved. This unprecedented project aims to provide young GBA music talents with a unique opportunity to perform in a youth symphonic orchestra of the highest level while collaborating and sharing experiences with other young artists. The 12-day summer camp preceding the debut concert tour was hosted at the HKAPA premises featuring a world-class group of coaches, an intense rehearsal programme, and cultural activities,” said Dr. Iñaki Sandoval, Dean of the School of Music, HKAPA.

School-enterprise cooperation empowers art and cultural integration of GBA youth

Conducted by Sharon Choa, Head of Conducting and Cultural Leadership of HKAPA, students from the three regions demonstrated their dedicated effort to the training. They cultivated rapport through performing selected music pieces, including Beethoven’s Triple Concerto, Dvorak’s Symphony No.9 “From the New World”, and Tan Dun’s Internet Symphony “Eroica”.

Through music, the GBAYO connects young people from diverse backgrounds who have similar aspirations to pursue their dreams together. The cooperation and support of all sectors of society is crucial to encouraging young people to participate in cultural exchange and maintain the sustainable development of the GBA.

“The development of the GBA has brought unparalleled opportunities on social, economic, and cultural fronts. As a company deeply rooted in Hong Kong with an expanding presence in the GBA, Swire is honoured to be Founding Patron of the GBAYO. Underlining our support is the belief that, through music, we can promote cultural exchange and youth development in the GBA, in line with our commitment to supporting the youth, arts, and the cultural enrichment of the communities in which we operate,” said Mr. Arnold Cheng, Director, Guangdong-Hong Kong-Macao Greater Bay Area, John Swire & Sons (China) Limited.

HKBU unveils treatment potential of herbal extract compound isoliquiritigenin for pancreatic cancer

A research led by scientists of Hong Kong Baptist University (HKBU) found that isoliquiritigenin (ISL), a flavonoid isolated from the Chinese herbal medicinelicorice, can inhibit pancreatic cancer progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer. It is the first time that a research group reported the anticancer potential of ISL in treating pancreatic cancer.

The research findings have been published in the international academic journal Phytomedicine and recently presented in the Annual Congress of the European Association for Cancer Research 2023 in Torino, Italy.

Pancreatic cancer as the “silent killer”

Pancreatic cancer is often called the “silent killer” as most patients experience little or no symptoms until it has advanced and spread. According to the Global Cancer Statistics 2020 released by the International Agency for Research on Cancer, the mortality-to-incidence ratio of pancreatic cancer is greater than 93%. It is the fourth leading cause of cancer deaths in Hong Kong.

Whipple (pancreaticoduodenectomy) operation is the only available curative treatment of pancreatic cancer. However, only 20% of patients are suitable for resection and the recurrence rate is high. In non-resectable cases and metastatic pancreatic cancer patients, the chemotherapeutic drug gemcitabine (GEM) remains the mainstream treatment. Nevertheless, GEM-based combination therapy exhibits profound chemoresistance with serious systemic toxicity.

Gancao extract identified as anticancer agent

In the search for alternative treatments for pancreatic cancer, a research team led by Dr Joshua Ko Ka-Shun, Associate Professor, Teaching and Research Division of the School of Chinese Medicine at HKBU, screened all the potential pancreatic cancer disease markers and the biological therapeutic activities of phytochemicals from the medicinal plant Glycyrrhiza glabra (licorice, or Gancao in Chinese) using network pharmacology.

Network pharmacology is an emerging discipline which systematically catalogue the molecular interactions of a drug molecule in a living cell using complex computations, and has become an important tool in botanical drug discovery. Using this approach, the team identified ISL as a potential anticancer agent for the treatment of pancreatic cancer.

With a series of cell experiments, the team demonstrated that ISL suppressed the growth and induced apoptosis (programmed cell death) of pancreatic cancer cells. In two human pancreatic cancer cell lines applied with 12.5 μM and 25 μM concentrations of ISL respectively, their cell survival rates were about 50% and 80% lower than the control cells with no ISL applied. The percentage of late stage apoptosis in the two cell lines was 11% and 13% respectively, compared to less than 5% in the control cells.

Inhibits cancer progression with fewer side effects

“ISL possesses a unique property of inhibiting pancreatic cancer progression through the blockade of autophagy, which is a natural process where the body’s cells clean out damaged or unnecessary components. The blockade of late-stage autophagy in our experiments results in cancer cell death,” said Dr Ko.

The research team further employed a mice tumor model to investigate the efficacy of ISL in inhibiting pancreatic cancer cell growth in vivo. The mice were divided into three groups with GEM (GEM group), ISL (ISL group) and no treatment agent (control group) applied. The ISL group was further divided into two sub-groups treated with 30mg/kg and 60mg/kg of ISL.

On the 21st day of the experiment, the tumor volumes of the control group and the GEM group were1000 mm3 and 400 mm3 respectively. The tumor volumes of the two ISL sub-groups treated with 30mg/kg and 60mg/kg of ISL were about 500 mm3 and 300 mm3 respectively. The results showed that ISL demonstrated treatment effects comparable to that of GEM. Meanwhile, compared with GEM, ISL showed fewer side effects in mice including neutropenia (drop in white blood cell count), anemia and body weight loss.

Enhances effects of chemotherapies

Current first-line chemotherapeutic drugs for pancreatic cancer, such as GEM and 5-fluorouracil (5-FU), are frequently associated with chemoresistance. It is because these drugs induce autophagy which favours the growth of cancer cells, and thus jeopardises their treatment effects.

To explore ISL’s potential in counteracting the chemoresistance of GEM and 5-FU, the research team set up experiments with pancreatic cancer cells treated with GEM or 5-FU alone, and GEM or 5-FU together with ISL. The growth inhibition rate of pancreatic cancer cells applied with GEM and ISL together is 18% higher than using GEM only, while the growth inhibition rate using 5-FU and ISL together is 30% higher than 5-FU only. The results showed that ISL can enhance the treatment effects of chemotherapeutic drugs by blocking autophagy, which is conducive to the death of cancer cells.

“The findings in this study open a new avenue for developing ISL as a novel autophagy inhibitor in the treatment of pancreatic cancer. We hope to collaborate with other research partners to further evaluate the effectiveness and potential clinical application of ISL in treating pancreatic cancer,” said Dr Ko.