St Petersburg University doctors first to prove the safety of COVID-19 vaccine for patients with chronic kidney disease

Nephrologists and geneticists from the Pirogov Clinic of High Medical Technologies at St Petersburg University have conducted a study on patients on haemodialysis for renal replacement therapy. They have also found out that vaccination against coronavirus disease (COVID-19) with the Sputnik V vaccine is effective and safe for patients with chronic kidney disease.

The study population consisted of 21 patients, aged 39 to 84, who had been receiving haemodialysis therapy for five and a half years. Before vaccine administration, none of them had had COVID-19 (confirmed or suspected). The study did not include patients who had: been on corticosteroid or immunosuppressive therapy; malignant neoplasms; or secondary immunodeficiency.

The first phase of the study was to monitor adverse reactions following the vaccine administration. According to the study findings, adverse reactions were reported in 30% of the subjects. After the second dose of vaccine was administered, pain at the injection site was reported in four patients, fever – in one patient, general weakness – in two patients, joint pain – in one patient, and muscle pain – in one patient. No allergic reactions to Sputnik V vaccine were reported in the study population.

The aim of the second stage was to determine the effectiveness of vaccination. Four weeks after the second dose of the vaccine was administered, two blood tests were performed on all patients: a COVID-19 Spike Protein IgG Antibody test – to determine the number of antibodies as a response to vaccination; and a test for COVID-19 T cells immunity – to determine the number of specific T cells responsible for the long-term immune response of the body – the so-called cellular memory. The efficacy of Sputnik V vaccine in haemodialysis patients was similar to its efficacy in the general population. In 20 of the 21 participants, either a humoral (antibody production) or cellular immune response to the vaccine was reported. Most importantly, the participants were closely monitored for five months after the vaccination. During this period, none of the patients developed SARS-CoV-2 infection.

The authors of the study are: Aleksei Tolkach, Ekaterina Parshina, Andrei Ivanov, and Pavel Kislyi, doctors from the Pirogov Clinic of High Medical Technologies at St Petersburg University. The study findings are published in the journal Nephrology and Dialysis.

‘The study findings suggest that the prevention of SARS-CoV-2 infection by full vaccination with the Gam-COVID-Vac, or Sputnik V, vaccine can be effective and safe for patients on haemodialysis for renal replacement therapy. It should be recommended for all patients when there are no contraindications to vaccination,’ said Dr Ekaterina Parshina, a co-author of the study. Dr Parshina is nephrologist and transfusiologist, Head of the Nephrology and Dialysis Department at the Pirogov Clinic of High Medical Technologies, St Petersburg University.

The doctors from the Pirogov Clinic of High Medical Technologies expressed hope that this study will help nephrologists and general practitioners who make decisions regarding the vaccination of dialysis patients. Dr Parshina noted: ‘We would like to assist patients in decision-making about the need for vaccination. Indeed, it is a difficult decision to make in the absence of a reliable evidence base, on the one hand, and an active anti-vaccination campaign, on the other.’

Short-term programmes in Mining University for students from Namibia and South Africa

Mining University, in conjunction with the International Competence Centre for Mining-Engineering Education under the auspices of UNESCO, offers a wide range of short-term programmes for international students. This autumn, St. Petersburg Mining University provided, amongst others, courses for Namibian and South African students.

One of the autumn schools – Digital Mining – was attended by participants from the universities of Namibia and Johannesburg.

Dr Pitchou Bukasa Mukendi, Senior Lecturer at the University of Namibia, shares his opinion on the programme:

“We are grateful to Mining University for having organised this programme and for the quality of education it offers. This has been an honour for us to participate in it. The lectures were very informative, and our students have learnt about what’s happening in the mining industry, new digital solutions, recent statistics. All in all – an incredible experience for both the students and us, lecturers.”

The Digital Mining programme was created by leading professors and specialists of Mining University. Aside from lectures, which covered such topics as, for instance, basics of modelling and simulation in engineering, the course included various workshops and masterclasses. Its attendees – altogether 40 students – have learnt how digital technology affects sustainability in mining and how AI can enhance the sector.

Monograph of TPU scientists published by Springer Nature

Springer Nature, an international academic publishing company, has published a monograph of scientists of the Division of Power and Electrical Engineering of Tomsk Polytechnic University. The collection is dedicated to power transformer diagnostics, one of the main problems of modern power engineering.

The monograph entitled Transformers Condition Control. Advanced and Traditional Technologies presents the physical reasons for power transformers’ failures, technical and economic consequences of disruption of normal operation, standard technologies for monitoring the state of the high-voltage transformers, as well as monitors the condition of transformer windings based on the pulse method.

“Probing with nanosecond pulses is to apply a rectangular pulse to the winding of the inspected transformer, the duration of which is about 100 nanoseconds.

Alternatively to the basic method suggested in 1966 based on the pulses of microsecond duration (a microsecond is a millionth of a second ed. note) used in Russian electric power systems until the end of the twentieth century, we use a pulse lasting for hundreds of nanoseconds. The pulse is applied from a special oscillator to the input of the transformer winding, responses or signals are picked up from the adjacent windings. The analysis of these responses allows concluding a failure or absence of failure,”

Alexey Mytnikov, Associate Professor of the TPU Division of Power and Electrical Engineering, one of the monograph authors, the co-author of the article, explains the core of monitoring the condition by the pulse method.

By reducing the length of the probing pulse and penetrating in a nanosecond range, the scientists were able to improve the efficiency of the diagnostics. The sequential research on the transition to a single stage, when only the probing pulse and switching pulses of the network are used, according to the scientists, bring the diagnostics of windings to the next level. All the results mentioned in the monograph and the ways of their implementation are used for the first time.

“At the moment, the frequency response analysis is recognized the most advanced in the diagnostics. Definitely, it is a good analysis, however, possesses essential disadvantages. We have shown that probing with nanosecond pulses is not inferior and somewhere superior to the frequency response analysis. Taking into account that the frequency response analysis was created in North American countries, patents for this analysis do not belong to the domestic electric power systems, therefore there are some difficulties implementing the analysis in the Russian electric power systems. The diagnostics trajectory chosen by us is quite relevant and promising,” the scientist adds.

The book describes the stages of improving the method based on a short probing pulse of the nanosecond range, the results of experiments on identifying radial and axial displacements of the winding, studies of the effect of the duration and shape of the probing pulse on sensitivity, sequentially presents the diagnostic procedure, as well as the stages of developing a mathematical and physical model of a power transformer.

“Despite the relevance and topical nature of the problem, there are not so many such publications. In our opinion, we were able to deeply analyze a variety of methods and ways of power transformer diagnostics, find out the problems and suggest the ways of solving them. Moreover, the ways of solving the problems are simple and effective, which is essential for modern power engineering.

“Despite the relevance and topical nature of the problem, there are not so many such publications. In our opinion, we were able to deeply analyze a variety of methods and ways of power transformer diagnostics, find out the problems and suggest the ways of solving them. Moreover, the ways of solving the problems are simple and effective, which is essential for modern power engineering.

The analysis results show that there is no applicable method to control the state of active parts of transformer equipment. In our monograph, we suggested and described our approach to solve the problem, a so-called probing with nanosecond pulses,” Alexey Mytnikov explains.

The monograph volume published by Springer Nature in 2021 is 150 pages. The editing lasted for one year. Vasily Ushakov, Professor of the TPU Division of Power and Electrical Engineering, an honored worker in science and technology became an editor and leader of the research writers who compiled the book. The co-authors of the monograph are Alexey Mytnikov, a leading expert in high voltage engineering at the All-Russian Scientific Research Institute of Technical Physics (Moscow), Professor Valery Lavrinovich and Alexey Lavrinovich, a postgraduate student of Tomsk Research and Planning Institute of Oil and Gas.

TMU launches training course on nuclear research reactors and cyclotrons

Tomsk Polytechnic University is giving an international advanced training course entitled Nuclear Research Reactors and Cyclotrons. Use, Facilities, Educational Programs. The advanced training course is designed for academic staff and managerial personnel of organizations from overseas partner countries of the Rosatom State Corporation.

The course was developed jointly with the Rosatom Technical Academy. The first participants who completed the course in 2018 were representatives from Zambia, Nigeria, Egypt, Serbia and Bolivia.

This year, the course is given in a hybrid mode for 10 days. A part of the participants came to Tomsk, while the others are joining the course online.

“The advanced training course in English gathered together over 30 participants from Egypt, Hungary, Serbia, Rwanda, Zambia, Ghana, Jordan, Nigeria, Kazakhstan, the Philippines, Bolivia, Indonesia, Mongolia, Congo and Bangladesh.

“The advanced training course in English gathered together over 30 participants from Egypt, Hungary, Serbia, Rwanda, Zambia, Ghana, Jordan, Nigeria, Kazakhstan, the Philippines, Bolivia, Indonesia, Mongolia, Congo and Bangladesh.

It is academic staff from higher education institutions, managerial personnel of organizations, who are involved in developing nuclear power programs,” says Vera Verkhoturova, Deputy Director and Head of International Nuclear Education Programs of the TPU School of Nuclear Science and Engineering.

The course program describes the practical experience of using nuclear research installations in the domestic nuclear industry. The course covers the following topics:

  1. basic characteristics, capabilities and application of nuclear research reactors;
    modern technologies and achievements of nuclear research reactors based on the Russian experience;
  2. construction features of the TPU nuclear research reactor, its main application areas, including industry, research and education;
  3. methodology, basic techniques of arranging and giving practicals based on the TPU nuclear research reactor;
  4. operation principles of research cyclotrons using the example of the TPU R7M cyclotron;
    main areas of the use of cyclotrons in nuclear medicine;
  5. methodology for students’ internship at the operating Russian research cyclotron;
    features of construction and application of betatrons in scientific, research, industrial and medical purposes;
  6. accelerators for use in medical purposes;
  7. application of radiotherapy devices for cancer treatment.

Mining University to develop unique solutions for increasing oil extraction efficiency

Saint Petersburg Mining University has a long history of cooperating with Gazprom, a Russian multinational energy corporation. A new agreement has just been made – university scientists will be working on a unique solution for increasing oil extraction efficiency. The results of their work will be applied at the Kovykta gas condensate field in Eastern Siberia.

High-salinity water may hamper the drilling operation, which is a common situation throughout the world. Therefore, reagents for constructing wells in the presence of polysalt and other aggressive components enjoy high demand. Their primary function is to prevent the fluid from a formation from entering the wellbore since starting production is otherwise impossible.

Abnormal pressures and temperatures, along with several other problems, however, pose significant risks. Solutions may turn into non-pumpable gel too early or, to the contrary, fail to reach the required consistency. This often happens in fields with specific reservoir properties (porosity, etc.) – the Kovykta field amongst them.

“The water shut-off technologies in use do not make allowance for the specificity of Russian deposits and their uniqueness. Hence, our task is not just to develop a solution that will maximise the production potential of one of the world’s largest natural gas fields. We also aim to provide a composition that would help increase the extraction efficiency of fossil fuels on a national scale,” says Andrey Kunshin, a Mining University researcher.
The university’s research team is currently looking into modern types of cement slurry and analysing their drawbacks. It is important because choosing the wrong one could complicate the drilling process and negatively affect production growth.
Building a test facility for dealing with energy challenges is next on the agenda. This project has yet to be patented, but the facility itself will supposedly be second to none in the world – at least, for now.
The site will be used for modelling processes taking place at the bottom of the well, including, in particular, contact with formation fluids or creating additional pressure. Thereby the scientists will learn how the new, improved composition reacts to entering an aggressive environment.

“Pilot testing at the Kovykta field will be the final stage of our work. The tests will be done together with our colleagues from Gazprom VNIIGAZ.

We expect to accomplish this science and technology objective Gazprom has commissioned us for during 12 months. The end product will speed up the time needed for constructing new wells. It will also lower reagent consumption and ensure the industrial and environmental safety of works carried out”, notes Dmitry Sidorov, Andrey’s colleague.

TPU-developed drug tested in Mexico to protect healthcare providers from COVID-19

An international research team, including the chemists from Tomsk Polytechnic University, proposed using a product based on silver nanoparticles to protect healthcare providers from COVID-19. It was successfully tested at the General Tijuana Hospital in Mexico. A total of 232 physicians and healthcare workers at the hospital who interacted with patients with the coronavirus disease took part in the voluntary trials. Only 1.8% of those who used the product fell ill or had a mild illness. Among those who did not use it, the illness rate was 28.2%. The research findings were published in PLOS ONE (IF: 3.24; Q1). The pharmaceutical product has also underwent a series of additional tests in an accredited laboratory in Spain.

Our international team includes both the university researchers from Tomsk Polytechnic University, the National Autonomous University of Mexico (UNAM) and a number of other institutes in Mexico and Spain as well as the developers from the research and production private companies Vector-Vita (Novosibirsk) and Bionag (Mexico). We have been researching into the preparations based on silver nanoparticles for the past 20 years, and extensively advancing them both in Russia and abroad. We have developed a basic drug called Argovit, and launched its production in Novosibirsk,” says Alexey Pestryakov, professor at the Research School of Chemistry & Applied Biomedical Sciences of Tomsk Polytechnic University.

The developed drug is a concentrate containing silver clusters (nanoparticles) no larger than 35 nanometers in size, surrounded by a polymer shell made of polyvinylpyrrolidone or gelatin. It can be diluted and used to create gels, ointments, sprays and liquid medications.

“We hold a whole set of patents for the formula itself, the technology, and its use to treat a number of diseases. It so happens that our team has close ties with the Mexican scientific and medical community. Therefore, a number of studies are being conducted there. In this country, a drug based on Argovit is successfully used, for example, to prevent and treat a diabetic foot syndrome and a number of other human and farm animal diseases (cow mastitis, canine distemper, shrimp white spot syndrome, etc.). In Russia, there is a form of the drug certified as a prophylactic remedy for oral cavity treatment. Since the drug has already shown its high effectiveness against bacteria and viruses, with the start of the COVID-19 pandemic, we assumed that it could be effective for this purpose as well,” explains the professor.

The Tijuana study was conducted over nine weeks in the spring of 2020. It involved two groups of healthcare workers. In the first one, 114 employees gargled their nose and throat twice a day with a solution containing silver nanoparticles. The second group of 117 people did not do it. Both groups used regular personal protective equipment for a covid hospital – masks, protective suits, etc.

“As a result, only two cases of infection were confirmed in the first group; those who fell ill had a mild form of the disease. In the control group, which included the healthcare staff of the hospital who did not use the Argovita solution, 33 employees out of 117 fell ill with COVID-19, i.e. 28.2%,”

says Alexey Pestryakov. In order to publish the research findings in the journal, we conducted a number of additional in vitro studies in Spain. Unfortunately, it took almost a year to publish the results. This is the reality that all drug researchers face, despite the urgency of the issue”.

The agent used in the study falls into the category of colloidal silver preparations.

“Silver belongs to the class of heavy metals, hence as regards its use in medicine, it is rightly subject to stringent requirements for toxicity. The peculiarity of colloidal silver drugs is that their effectiveness and safety depend on many factors: the size of nanoparticles, their shape, the polymer shell used. The creator of each particular drug has to prove the efficacy and safety of the substance. We have gone all this way before. The substance itself and the drugs based on it have an extensive scientific evidence base for safety and efficacy. We have published over 80 scientific articles with the research results, obtained over 20 patents and patent applications. The research proves that in therapeutic doses the drug is not toxic,” the researcher says.

According to an expert, Mexico is now in the process of registering the drug for use as a prophylactic remedy against COVID-19.

“Our ultimate goal is to eventually use the drug in therapy and, of course, in our country. This summer, the medical institute of the North Caucasus State Academy in the city of Cherkessk conducted a study of the drug with the voluntary participation of 92 patients with COVID-19 in mild and moderate forms.

They were all treated with a standard therapy for this disease, however the inhalations with our drug twice a day were additionally included in the treatment regimen. The obtained results proved the increase of therapy efficiency when including nanosilver drug in the complex treatment regimen for COVID-19, at least for its mild and non-neglected forms of the disease. The treatment periods were shortened by an average of four days,” adds Alexey Pestryakov.

For more details about the research findings, please, refer to the article published in the Siberian Scientific Medical Journal.

Looking for the Earth’s twin

What is a hot Jupiter? How can an Earth-like planet be discovered? How can it help us learn more about our planetary system? Roman Baluev, Candidate of Physics and Mathematics, Senior Research Associate in the Department of Astronomy at St Petersburg University, answers these and other questions about modern astronomy.

Mr Baluev, could you please explain what exoplanets are? What are they like?

Exoplanets are planets that orbit around stars other than the Sun, i.e. outside the solar system. Among the first planets to be discovered since 1995 were the so-called hot Jupiters.

Scientists have discovered a whole class of celestial bodies that are similar in mass to our Jupiter, but are much closer to their star, at a distance of less than 0.1 astronomical unit. As a result of such a short distance, their atmospheres are heated to enormous temperatures of about 1,000 K. The Solar system has no such planets.

An astronomical unit is a traditional unit of measurement in astronomy that amounts to the average distance from the Earth to the Sun. For example, the distance from Mercury (the closest planet to the Sun) to the Sun is about 0.3-0.4 astronomical units.

At first, it seemed to be the dominant class of extrasolar planets as other types were very rarely found. It can be explained by the fact that hot Jupiters were much easier to detect given the accuracy of the measuring instruments that existed at the time. Later on, however, from the year 2000 or so, when the equipment became more advanced, more distant planets, including those similar to our Jupiter, have been discovered. It became clear that the class of hot Jupiters is not that numerous.

Moreover, among the extrasolar planets, there were also discovered hot earths, which are located very close to their stars. As a result of the high temperatures, there is no life on them, nor can there be any. There are also hot Neptunes (or hot super-Earths).

Why are scientists searching for new planets? What does it help to understand?

For a long time, researchers have built theories about the formation of planetary systems and based them only on the data from the solar system. However, planet Earth is quite special – we and other living organisms emerged here. Apparently, this is a rare occurrence in the Universe: we know of no other such examples. One could study our planetary system in detail down to its chemical composition and the origins, but this would not answer the question of whether it is unique or whether it is a universal standard?

The first discoveries of exoplanets provided additional statistics which were enough to develop a new theory of planet formation. Hot Jupiters, for example, shattered existing beliefs, as their origin cannot be explained by the old theories. Our planetary system has only one Jupiter at a distance of about five astronomical units from the Sun, and it has a substantial mass. The inner region of the solar system has only small planets: Mercury, Venus, the Earth and Mars. The first exoplanets that have been discovered have a mass comparable to that of Jupiter. However, they are 20 times closer to their star than the Earth is to the Sun. Their origins are unclear: located so close to a star, they simply could not have had the material to form a planet of such mass.

Scientists have therefore developed a theory of planetary migration. It suggests that a planet is formed far away from the star but, through interaction with the protoplanetary disk, it gradually moves closer to the star and migrates towards the central regions. We can detect the planet now by observing the scattering of material from the protoplanetary disk.

A protoplanetary disk, or proplyd, is a disk of dense gas, which subsequently forms planets, that rotates around a young star.

This raises the question of why our Jupiter has not migrated. It can be down to the parameters of the protoplanetary disk: the amount of matter that was initially there; its viscosity; and its chemical composition. There is a whole field of research in mathematics, hydrodynamics, and even magnetic hydrodynamics to explain this.

There has also been further development of the theory of gravitational instability in the protoplanetary disk, which has explained the presence of such planets in the central regions around the star without migration. The discovery of exoplanets gave a good impetus to this research and formed an entire branch of astronomy.

What can astronomers learn about exoplanets staying so far away from them on Earth?

The planets that revolve close to the star are so hot that they emit their own light in the infrared band and this light can be detected as they drift behind the star’s disk. As the planet emerges from behind the disk, it slightly contaminates the star’s light. If we look at the spectrum, we see that the planet adds its own lines which can be registered and interpreted.

This is how we get information about the general composition of the planet’s atmosphere. This is useful as since we know the chemical composition of the gas giants in the solar system, we can tell the differences in the chemical composition of exoplanets. This has become a branch of science in itself.

Another field involves the study of the atmospheric dynamics of planets. When a planet passes behind the disk of a star, this effect can be recorded and the asymmetry of this phenomenon in the infrared region of the spectrum can also be measured. This provides information about the scattered light surface brightness distribution of the visible disc of the planet. After all, the star heats the planet unevenly – the atmosphere is always hotter in the centre (at the equator). Moreover, the planet rotates and, due to various hydrodynamic effects, there are strong winds. The hot spot may shift and take some non-trivial forms. This is how we can get information about the hydrodynamics and thermal profile of the planet.

As there are many types of exoplanets, they become a kind of experimental cauldron, an experimental laboratory created by nature.

What methods are used to detect planets?

There are several ways of detecting extrasolar planets. One of the principal methods is the radial velocity method, or Doppler spectroscopy. Earth-based telescopes enable us to observe the star ‘wobble’ as a result of gravitational disturbance from the planet. What we can see is not even the ‘wobble’ itself but variations in the star’s radial velocity. It is the speed at which the object moves away and towards the observer, which can be measured by spectroscopy. In other words, we find an exoplanet by the change in the subtle characteristics of the star’s light, or, more precisely, by the periodic shift of spectral lines due to the Doppler effect.

The Doppler effect, named after the Austrian physicist Christian Doppler, explains the change in frequency and length of waves caused by the movement of their source and receiver in space.

There is also the astrometric method, when scientists measure the direct oscillation of a star around the centre of mass of the planet, rather than the spectral parameters of the star’s luminescence. This is a rather exotic method because such an effect is very difficult to capture. It was for this kind of measurement that the Gaia astrometric spacecraft was launched in 2013. It has been flying for some time now and may be able to discover many new planets in the future. However, the data it has collected so far is insufficient as such precise measurements require the full amount of information from the entire expedition, and it still needs to be processed by special algorithms.

Another method is microlensing, which makes it possible to discover planets orbiting very distant stars. From the Earth, clusters of such distant and dull stars merge to form the Milky Way. Sometimes two unrelated stars can be at different distances from the Earth but happen to align in the same line of sight for us. At this point, the closer star will use its gravity to focus the light of the background star onto the observer. At this point, the background star will have brightened for a period ranging from a few hours to several days. If there are planets rotating around the nearest lensing star, each of them will also play the role of a small lens. On the light curve, we will see the anomalies caused by these planets.

Everything has to be right: the stars should align on the same line; and the plane of the planets’ orbits and the planets themselves should take the right position. This is a very rare and unlikely event. This method, nevertheless, was popular at the time of the OGLE project on microlensing, during which there was discovered a considerable number of planets in our galaxy. However, this method had an important drawback as microlensing happens only once for each object.

The OGLE (Optical Gravitational Lensing Experiment) is a Polish-American project to study dark matter using the method of gravitational microlensing.
One of the current methods of detecting exoplanets, which competes with the radial velocity method, is the transit method. It uses photometry and is primarily aimed at the planets orbiting close to the star. At such a distance, the planet’s plane of rotation is likely to pass through the Earth and we will periodically see the celestial body projected onto the star’s disk. The planet in this case remains invisible to us, but we do observe that it slightly dims the star’s light by about 1% in recurring periods. To spot this, we need precise photometry, which is simpler than the radial velocity method. The Doppler method requires special highprecision spectrographs. In the case of the transit method, such precision is not required.

The transit method, however, has another drawback: the planet’s orbit has to be oriented towards the Earth for the transits to occur periodically. If its orbit is flat, the transit will not be detected. The probability of such a plane orientation is quite low. If a planet is as far away from a star as the Earth is from the Sun, the probability of detecting it is very small. It increases if the planet orbits close to the star, but is still low.

What method do you use in your research?

The transit method has a spin-off, namely the transit-timing variation. Suppose there is a planet orbiting a star, and due to a certain plane of its orbit it periodically passes in front of the disk of that star. If there is one planet, the transit repeats with the planet’s orbital period.

However, if there is another planet that remains invisible, it will gravitationally affect the first planet and perturb its motion, thus disturbing the strict periodicity. So, one transit event will be a little delayed or ahead of the projected moment. Such deviations might suggest that there is another object in the system. Celestial mechanics can tell us a lot about an object and even help to calculate and construct its orbit.

Such deviations in timing can also occur because of the tidal interaction of the planet with the star. Over time, a planet loses energy and spirals slowly towards the star due to the small distance between them. The tidal force causes them to affect each other in the same way that the Moon causes the Earth’s tides. The planet is flattened and this deformation causes a continuous change of direction so the planet always faces the star with one side. Due to this effect, there is a loss of energy in the planet’s core. This means that the orbital velocity of the celestial body gradually increases. According to Kepler’s law, the closer an object to the star is, the faster its companion should move. It is a microscopic effect: in the case of the Earth, for example, the accumulated deviation in timing turns out to be only about a couple of minutes over a 10-year observation period.

There are two such planets known today: WASP-12 and WASP-4. The latter is being observed in South America by amateur astronomers at our request as part of the EXPANSION project, which I will talk about a little later. The study was carried out in parallel with another international team and they happened to publish the results first as they had observed the accelerating moments of the transits. We were more cautious and noted some complications in interpreting the data.

The observed effect could have been the result of systematic errors, in particular the impact of stellar spots. If a star has homogeneous brightness over its entire disk, the transit will look beautifully smooth, just like in the textbook. Stars, however, almost always have spots and it may happen that a planet will take a ‘splash’ over the top of this spot during its passage. Then the photometric curve would show an anomaly, which would distort the result. In the end, we did confirm the timing acceleration effect, but the amplitude of the systematic acceleration was half what the second scientific team had claimed.

How do astronomers acquire data on exoplanets?

A colleague of mine, Evgenii Sokov, has organised an international network of telescopes among amateur astronomers, which also includes professional observatories. The network is made up of several dozen telescopes that conduct regular observations of the transits of various exoplanets across the sky. There are now just over 20 such planets, and WASP-4 was one of them. These planets have long been known and described, and we continue to accumulate data on their timings, thanks to the project.

This project sprang from the Czech Exoplanet Transit Database. For some time, observations of varying quality have been accumulated in this database, but most of them are not of very high quality as they were taken by amateurs. Such data should be carefully selected and include only the objects whose data quality is more or less adequate. On the basis of this database Evgenii Sokov has founded the EXPANSION project and brought together people who are willing to conduct observations of exoplanets on a regular basis.

We also cooperate with the Special Astrophysical Observatory of the Russian Academy of Sciences. They have recently commissioned a new spectrograph with the level of precision that enables observations via the radial velocity method.

Is there any chance of finding an Earth twin?

Astronomers around the world would certainly wish to discover such a planet. This is the cutting edge of exoplanet research and the most intensive studies are being conducted in this field. However, the task is not easy: you need to find a planet with the same mass and at the same distance from the star as the Earth. There is no point in finding a white-hot Earth where no life can exist.

A full twin to the Earth has not yet been found. However, similar planets have been discovered near low-mass red dwarfs. Due to their low mass, these stars are more sensitive to planetary disturbances, making it easier to discover lower-mass exoplanets near them. Red dwarfs also have a life zone closer to the star because they produce a fainter light than the Sun. Their exoplanets can orbit closer to the star without getting as hot as hot Jupiters.

The habitable zone or life zone is the area around a star with the most favourable conditions for Earth-like life.

Looking for a complete analogue of the Earth requires a high precision spectrograph with a radial velocity measurement accuracy of 10 centimetres per second. The best spectrograph available today only allows an accuracy of 30 centimetres per second. The search for twin Earths is therefore a great challenge for engineers in many ways. High precision instruments need ultra-high stability. To achieve this, they are installed in a special protective case that maintains constant pressure and temperature.

High precision instruments are not enough. It is important to remember about spots and other unstable phenomena, such as flares, granulation and so on, in the photosphere of a star. Roughly speaking, the surface of a star is turbulent and this causes additional noise and distortion in the measurable radiant velocity. As a physical object, a star’s radial velocity doesn’t change. However, the problem is that it is not measured directly – we use a spectrograph based on the Doppler effect. The spectra of a star reflect its unstable outer envelope. This instability varies by one metre per second.

In short, to minimise the natural astrophysical noise of a star, it is necessary to create special algorithms that will process and filter it. This is the only way to achieve the accuracy needed to discover an Earth-like planet. No matter how difficult it is, I think it will happen sooner or later.

How material for high-speed switchable devices transitions into conducting state

A team of physicists from Saint Petersburg Electrotechnical University “LETI” studied and described the main factors that affect the transition of vanadium dioxide (VO2) thin films into the conducting state. The team identified two different transition mechanisms that depend on the number of defects in a sample: the fewer defects, the less voltage is required for transition, and the more independent voltage threshold is from temperature. The results of the study were published in the Chaos, Solitons & Fractals journal.

In their normal state, vanadium dioxide (VO2) films cannot conduct electricity. However, when subject to a certain voltage level, their resistance reduces by up to a hundred thousand times. Such a transition can happen very fast — in less than a picosecond. The mechanism of this process is still largely unknown, but this unique property makes vanadium dioxide films a promising material for smart windows, thermal imagery sensors, and artificial neurons for next-generation computers.

“One potential area of application of VO2 thin films is active memristors. Thanks to resistive switching in active memristors, they can be used to simulate the behavior of voltage-gated ion channels in biological neurons, and phase transition in VO2 thin films makes it possible to model different types of spike activity of neurons. Potentially, the modeling results could help scientists study the time synchronization of the neurons that support the functional activity of the brain and find ways for their synchronization or modulation. Based on these studies, non-pharmacological correction methods for certain functional brain states could be developed,” says Natalia Andreeva, a lead researcher at the Nanotechnologies Science and Educational Center of ETU “LETI.”

In its work, the team from ETU LETI studied the switching dynamics in a broad temperature range: from -200 to +20°С. To do so, they made several identical samples by covering a sapphire base with a thin layer of vanadium dioxide using the method of reactive magnetron sputtering. During this process, particles are dislodged from a bar of the sputtered material by gas ions in a strong magnetic field. Then, different voltage levels were applied to the samples at different temperatures, and the team studied the current flows through VO2 thin films.

Based on the experiment results, the team divided all VO2 thin film samples into two types. The first one required more voltage to transition to the conducting state when the temperatures went down, and the second one did not exhibit any threshold voltage changes correlating with temperature. According to the team, the difference might be due to the number of defects, namely, ions of hydrogen and oxygen vacancies (i.e. areas lacking atoms of oxygen).

In some cases, the defects could act as electron traps, and for the transition to the conducting state to happen, all of them should be filled. This requires a certain threshold voltage. When a sample has a relatively small number of defects, the threshold voltage is low and does not depend on the temperature; the transition to the low resistance state in VO2 thin films is preferably electronically driven. On the contrary, at increasing the number of defects in a sample, the higher voltage bias is required for the transition to the low resistance state, and more likely that it is triggered due to thermal heating. In this case, the threshold voltage is temperature-dependent. When a sample is cooled down and subject to a voltage at the same time, more voltage is required for the transition with the temperature decreasing.

“We are going to continue working on this task in the framework of the state project “Bionic neuroarchitectonics.” Namely, we plan to model neuroprocessing activity using cutting-edge smart materials and technologies,” concluded Natalia Andreeva.

SPbU scholar on amending Criminal Code on abduction

According to official statistics, about 350 people are kidnapped in Russia every year. However, this number does not include the abduction of a child by relatives, because law enforcement authorities generally avoid initiating such criminal cases. Evgeniia Ivanova, a scholar from St Petersburg University, explains the cases when father and mother have the right to decide where and with whom a child lives, and when the law prohibits it.

In her dissertation ‘Abduction: Qualification and Liability’, Evgeniia Ivanova studied more than 1,300 cases of abduction and formulated recommendations on improving legislation in this area.

Ms Ivanova, why have you chosen abduction as the subject of your research?

There were a number of reasons. First and foremost, it was the wording of the Article, which is not ideal. The law provides only a name for the crime without defining it, so it is not very clear what the offender has to commit for it to be called abduction. Is it necessary to keep a kidnapped person in captivity for a long time or just a few hours? Is it necessary to have the abducted person removed somewhere, and does the distance matter? Is the motive and purpose of the abductor important? The law does not provide answers to these questions. Secondly, abduction is a crime that infringes on a person’s physical freedom. However, the law does not give us a clear definition of what freedom in general and physical freedom in particular is. Moreover, in reality not all people can exercise such freedom fully at their discretion. The insufficient research into these issues has piqued my interest and led to such research.

What kind of people do not have full control over their physical freedom?

There are three categories. First, there are those whose sentence involves the deprivation or restriction of physical liberty. Obviously, people held in correctional institutions are not free to move around. Secondly, there are people who have been appointed custody because of their incapacity. The place of residence of such people is determined by their guardians. Thirdly, there are children, who are underage.

Is this why you focus so much on the liability of parents and relatives for abducting children? Is it because the physical freedom of children is of specific nature?

Absolutely. It is also a pressing social issue. I think each of us has heard of scandals involving the kidnapping of children by their parents or other relatives. Foreign countries have the practice of prosecuting such people. However, Russian law enforcement agencies are reluctant to initiate criminal proceedings, citing that the Criminal Code does not stipulate such liability.

Is there no provision for it?

Parents are not liable because under the law (the Constitution and the Family Code) they are the ones who are responsible for where and with whom the child lives. The conflict between the parents over the removal of a child is therefore a matter of family law, not criminal law. The situation is quite the opposite if one of the parents is deprived of parental rights. If there are no parental rights, there is no right to determine the child’s place of residence. The person is legally a stranger to the child, so he/she becomes liable for kidnapping. The same applies to grandparents and other relatives of the child. They do not have the right to dispose of the physical freedom of the child, so they shall be held liable.

What if a child wants to live with a relative or a parent who has been deprived of parental rights? Should this be taken into account?

All things are considered, but only if the issue is resolved by legal means, whether it is a grandmother trying to get custody of a child or a parent trying to recover parental rights. Simply removing a child bypassing the legal procedure is a crime, and the opinion of a child, whatever age he or she may be, is legally irrelevant. However absurd it may seem, but a direct interpretation of the norms of the Constitution of the Russian Federation and the Family Code of the Russian Federation implies that for any minors the decision concerning their residence is made by parents. It is rather strange when a person aged sixteen can take care of their own medical matters, can get a job, can be held criminally liable, and at the same time is dependent on parents to determine the place of residence and spending leisure time.

What happens if living with parents endangers the life and health of a child, and a grandmother has to remove the child? Is it right to charge her with a criminal offence?

It is certainly wrong. That is why the Criminal Code of the Russian Federation provides for an exemption from liability for a person acting in cases of extreme necessity. If a child may be harmed and a person saves him or her, it is an act of extreme necessity.

Are there any changes that you could suggest to the Criminal Code that would allow improvement of the criminal legislation, in particular concerning the issue of criminal liability of child’s relatives?

My dissertation includes such proposals. However, it is a social problem and such problems cannot be solved solely by the norms of the most repressive branch of law, criminal law being the most repressive of all. It is necessary to develop comprehensive mechanisms that involve both family and civil law to ensure that the course of action of individuals in a given situation is clear.

The text of the dissertation and a video of the defence are available on the website of St Petersburg University.

Speaking about abduction in general, rather than just children, is it possible to solve the problem with legal instruments?

We can take measures to improve legislation and adopt acts at the level of the global community. However, crime is a social phenomenon, and in my opinion, the most effective way to reduce it is through social mechanisms.

Are there examples of countries where the problem of abduction has been, if not completely solved, then minimised?

Since 1 September 2016, St Petersburg University has been entitled to form its own dissertation councils to award the degrees of St Petersburg University.

In the course of my research, I have not come across a country that does not have provisions for abduction in its legislation. In my opinion, this shows that this offence is common to any state and is ‘normal’, insofar as one can speak of normality in relation to destructive behaviour. Of course, the specific nature of abduction varies from country to country. For example, in China, women are often kidnapped for the purpose of marriage, which is a result of the demographic situation (there are considerably more men than women in the country). The problem of abduction is unlikely to be completely solved.

Could you please tell us about the defence of your dissertation?

My defence was held in a mixed format: the members of the council who were in other countries and cities were present remotely. Of course, this was rather unconventional, but everything went well, largely thanks to my long experience of distance working at the University. The entire procedure took about 2.5 hours and I received a lot of very different questions from the members of the dissertation council. It was certainly an interesting experience.

Is the defence procedure under the rules of St Petersburg University difficult?

The defence does not seem very complicated. All the requirements for candidates are justified and the mechanism for submitting and verifying documents is well established. I personally had difficulties in selecting a foreign expert, but I admit that this is related to the topic of my research. What is unusual is the absence of opponents: the members of the dissertation council act as both evaluators and critics of the work. In my view, it is not therefore the candidate, but the members of the dissertation council who may find it most challenging.

What do you think of the requirement to publish the research in two languages?

Publication of research in a foreign language is necessary, in my point of view. This solves a number of problems in popularising the research abroad, since not every foreign specialist has a sufficient command of Russian to study scientific works.

What are your plans now, after the defence? Does a PhD degree open new doors for you?

Of course, having a PhD degree is very important. It will contribute to my teaching career at St Petersburg University.

Furthermore, I have already submitted a proposal to St Petersburg University Publishing House for the publication of my monograph. I would like to see it published this year. There are not many monographs on abduction, so my research might be useful.

 

LETI’s research will help apply magnetotactic bacteria in oncology

LETI researchers identified the main properties of magnetotactic bacteria and described the possibilities of their application in medicine. The results obtained will help create theranostic agents in neurooncology and cardioprotection. The results of the joint study with colleagues from St. Petersburg State University, RAS Institute of Cytology, and RAS Institute of Biotechnology were published as a review article in the journal Magnetochemistry.

Magnetotactic bacteria (MTB) are distinguished by their ability to synthesize magnetosomes, special cellular organelles in which magnetite biomineralization occurs. Thanks to their magnetic properties, MTBs and isolated magnetosomes can be used in medicine to fight cancer. Using magnetosomes, drugs will be transported directly to the malignant tumor. In addition, scientists aim to study the formation of bacterial magnetite crystals inside MTB cells, the mechanisms of magnetostatic interaction between individual magnetosomes, and their chemical and aggregative stability outside the bacterial cells. These results become the core of research in paleomagnetism and the physics of magnetic phenomena.

Currently, scientists from Germany, France, Brazil, the USA, and Japan are engaged in large-scale research of magnetotactic bacteria. The research conducted by LETI scientists will be the first in St. Petersburg. LETI chose an interdisciplinary approach: the university formed a research team, which includes specialists in different fields – physics of magnetic phenomena, rock magnetism and magnetofossils, neurooncology, and target therapy based on nanoparticles, as well as the synthesis of composite magnetic particles based on iron oxide. That will make it possible to carry out a versatile study and obtain objective results.

“We expect to eventually complete the full cycle of research – from fermentation of MTBs in high throughput automated bioreactors of large volume and evaluation of their physical characteristics to functionalization of magnetosomes with pharmaceuticals and their laboratory tests. Thus, subject to the achievement of the set goals, for the first time in our city, there will be world-class results in this field of science,” says Kamil Gareev, Associate Professor of the Department of Micro- and Nanoelectronics of LETI, Senior Researcher of the Engineering Center for Microtechnology and Diagnostics.

The next stage of studying MTBs will bring scientists closer to the practical use of structures based on bacterial magnetosomes in medicine as new tools for targeted drug delivery, hyperthermia therapy, and contrast agents for magnetic resonance imaging. “Compared to currently used structures based on synthetic iron oxide nanoparticles, bacterial magnetite has better chemical stability, high uniformity in shape and size, and, even more importantly, high biocompatibility,” commented Kamil Gareev.

LETI scientists obtained the first results of studying magnetic nanoparticles in 2013, and since then, research in this direction has continued. Until 2021, the research mainly focused on the properties of synthetic, rather than biogenic, magnetic nanoparticles, such as magnetosomes. The long-term experience allowed researchers to move on to a full-fledged study of magnetotactic bacteria and bacterial magnetosomes.