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Complement-Mediated Diseases

Observation and precision are qualities that have become not just desirable but essential in many modern professions. This is especially true in medicine, where such traits are indispensable for neurologists and nephrologists alike. These two specialties were at the heart of a recent educational seminar organized by the Department of Nervous Diseases at S.D. Asfendiyarov Kazakh National Medical University. The event was part of a broader series of educational initiatives marking the 95th anniversary of the university and commemorating the 90th anniversary of Professor S.K. Kaishibayev. Held on June 18, the seminar formed part of the university’s implementation of a cascade training model for healthcare professionals. It aligned with the Roadmap for Improving Neurological Care for the Adult Population of the Republic of Kazakhstan for 2025–2027 (No. 03324 dated January 23, 2025). The event was supported by the “Association of Neurologists” NGO of Kazakhstan, the Department of Nephrology, and the Institute of Postgraduate Education at KazNMU. The seminar focused on diseases related to complement system dysfunction — a crucial component of the immune system. When improperly activated or insufficiently regulated, the complement system can become a source of damage, contributing to the development of autoimmune and inflammatory diseases. Among these are conditions such as myasthenia gravis and thrombotic microangiopathies (TMAs), which were key topics during the session. The clinical aspects of myasthenia gravis in children and the targeted use of anti-complement therapy were discussed in detail, highlighting both therapeutic targets and the evidence base supporting this approach. TMAs, increasingly encountered over the past decade, were examined through an interdisciplinary lens. Despite growing awareness among clinicians, the complexity of differential diagnosis in such conditions remains a significant challenge. The seminar featured presentations from Dr. S.T. Turuspekova, Head of the Department of Nervous Diseases at KazNMU; Professor G.A. Mukhambetova; Associate Professor R.B. Nurzhanova; and Associate Professor N.B. Nigmatullina from the Department of Nephrology. They shared insights into diagnostic strategies, modern therapeutic approaches, recent clinical data, and evolving treatment assessment techniques for generalized myasthenia gravis. Of particular interest were clinical case presentations on TMAs by Associate Professor Nigmatullina, who shared her unique experience with anti-complement therapy, offering valuable practical perspectives to attendees. The seminar brought together 25 neurologists and nephrologists from various medical institutions across Almaty. Participants praised the high level of expertise and professionalism demonstrated by the speakers. The event received informational support from the Karaganda Pharmaceutical Complex.
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