NITech researchers’ new study could pave the way for sustainable energy source

The material strontium titanate (SrTiO3) has shown immense potential as a photocatalyst in solar energy conversion, but it is unclear whether chemical defects can influence its properties. Researchers at Nagoya Institute of Technology, Japan, have looked into how doping with niobium affects the charge properties of SrTiO3 crystals. Their findings can help us to increase the efficiency of SrTiO3 photocatalysts, opening doors to a sustainable energy source.

In their study published in the Journal of Physics D: Applied Physics, the researchers looked at the effects of low-concentration Nb doping, as well as no doping, on the surface recombination in SrTiO3 crystals. Prof. Kato explains, “Quantitatively measuring the effects of surfaces and niobium impurities in SrTiO3 on carrier recombination can help us design photocatalysts with an optimal structure for artificial photosynthesis.”

The scientists first analyzed the surface recombination, or “decay,” patterns of undoped SrTiO3 samples as well as those doped with different concentrations of Nb, using a technique called “microwave photoconductivity decay.” To further probe into the bulk carrier recombination properties of doped samples and different energy levels introduced by Nb doping, another technique called “time-resolved photoluminescence” was used.

The researchers found that the recombination of excited carriers was not dependent on their concentration, indicating that they recombined via “surface” and “Shockley-Read-Hall” processes (which are insensitive to exciting carrier concentration). Moreover, the doped sample showed faster decay curves, which could be due to the introduction of a recombination center by Nb doping. Doping the material with high concentrations of Nb showed negative effects on carrier doping. Moreover, the size of the photocatalyst, and not its shape, influenced surface recombination and ultimately its overall efficiency.

The study concluded that moderately Nb-doped SrTiO3 could actually be more beneficial than pure SrTiO3, especially when operated at higher operating temperatures. These findings can help us design SrTiO3 photocatalysts with a lower surface recombination and higher energy conversion, leading to the development of efficient, sustainable sources of energy.

Prof. Kato optimistically concludes, “We are confident that our findings can accelerate the development of artificial photosynthesis technologies, ultimately contributing towards a greener, more sustainable society.”

 

Chulalongkorn University researchers innovate a smartwatch that can measure blood glucose from sweat

The Metallurgy and Materials Science Research Institute, Chulalongkorn University will soon launch a cutting-edge, health innovation – a wristwatch that can check blood sugar levels from sweat in real-time.  It’s accurate, not painful, less expensive, and can replace imported equipment.  It is expected to be available on the market soon.

The research team introduced the ultimate wristwatch that can measure blood glucose and lactate levels from sweat, received a Good Invention Award for Science and Pharmacy, 2021, and a collaboration with the National Science and Technology Development Agency (NSTDA).

The Metallurgy and Materials Science Research Institute

According to Dr. Natnadda Rodthongkam, Deputy Director of the Metallurgy and Materials Science Research Institute, “Medical reports indicate that the level of glucose in sweat is directly related to blood sugar.  So, we used this finding to innovate a device that helps tell the patient’s glucose level in real-time. This is very important to the daily life of diabetic patients who must regularly monitor and control their blood sugar levels.”

“Moreover, it helps reduce the burden of healthcare workers.  Patients do not have to waste money and time travelling to the hospital and risk complications.”

Diabetes is a common disease among the elderly.  According to the Diabetes Association of Thailand’s report, in 2020, up to 5 million Thai people suffer from diabetes.  More importantly, diabetic patients also experience muscle weakness caused by the disorder of the immune and nervous systems.

Currently, the methods used to determine blood sugar levels are by drawing blood from the fingertips according to the fasting plasma glucose standards for diabetics, together with a lactate test to measure the concentration of lactate. Patients with muscle weakness need to fast for at least one hour before they can draw blood.

“Knowing real-time blood sugar and lactate levels will help patients take care of themselves, adjust their behaviour, or seek immediate medical attention before it becomes dangerous. We, therefore, devised a method that is faster, more accurate, and doesn’t need fasting or drawing blood, ”said Prof. Dr Natnadda.

This Chula-NSTDA joint project has researched and developed a special yarn material that is biochemically modified to absorb sweat and is sensitive to glucose and lactate enzymes in a single device.  Diabetics can monitor their blood glucose and lactate level anytime while wearing this smartwatch.

“This special yarn transmits the obtained data to a test sheet inserted inside the smartwatch case… to compare the measurement against a standard Calibration Curve.  If the blood glucose is low, the colour will be light, if high, the colour will be dark, while the lactate value will appear even darker in colour, “Prof. Dr Natnadda explained.

Currently, the research team is testing the effectiveness of the watch on diabetics and weak muscles, with cooperation from physicians specializing in diabetes treatment and the Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital. After successful testing to ensure its performance, this device will be further developed to be used by real diabetic patients soon.   The team also anticipates that this smartwatch will be popular among patients, and can help reduce the cost of importing high-priced medical devices from abroad.

Fibre-optic sensors could help control the quality of roads

Researchers from Saint Petersburg Electrotechnical University ETU “LETI” and Riga Technical University tested new technology for monitoring the state of the roadway surface. Fibre-optic strain and temperature sensors collect data on changes in the roadway structure depending on the load. This information will help design durable roads and plan their maintenance. The study was published in the Journal of Sensors.

The pavement of any road deteriorates over time. It is impossible to stop this process altogether, but it is possible, on the one hand, to choose more durable materials and, on the other hand, to repair cracks and ruts in the roadbed structure in the early stages, until the damage requires replacing the entire surface. Therefore road construction industry is always looking for effective monitoring systems along with new materials. Roads should be equipped with sensors that allow not only to detect defects timely but also estimate the load on the road section. Using this information, a maintenance team could understand the levels of pressure and vibration created by traffic in that area and reinforce the roadway surface where needed.

Dmitry Redka, Associate Professor of the Department of Photonics of ETU “LETI,” used fibre-optic sensors for asphalt pavements in a joint project with Riga Technical University. TThese devices are known for their sensitivity and can be arranged in existing fibre optic networks to remotely collect data, so they do not require an electrical power supply. The sensors are based on the so-called fibre Bragg grating. It is a short segment in an optical fibre in which the refractive index is variated using UV light. As a result, this segment always reflects radiation only in a very small spectrum and transmits the rest of the light without loss.

FBG can be constructed so that the wavelength of the reflected light depends on changes in the ambient temperature, pressure on the fibre, or other parameters. Fibre optic sensors work thanks to this effect. For example, a temperature sensor will reflect a laser signal differently at +20°C and -15°C.

Dmitry Redka, Associate Professor of the Department of Photonics of ETU “LETI,” explains: “Our experiments show that fibre optic sensors can accurately measure roadway deformations. It is necessary to monitor the temperature because, in warm weather, asphalt is more pliable, and strain values increase. Using our constant monitoring approach, one could determine when deformations exceed the limit in a section and take it into account when designing new roads and repairing existing ones.”

Researchers embedded two types of fibre-optic sensors for measuring strain and temperature in a layer of asphalt on a Latvian road during its maintenance. The sensors were placed 25-30 mm deep at two points on one side of the roadway. Because unprotected fibre-optic sensors are fragile, they were encased in composite and ceramic tubes.

To test if the system is working, researchers used a falling weight deflectometer, a device measuring the surface deflection under load. The centre of the plate, on which the load falls, was placed at different distances from and directly above the sensors. This test showed that the most accurate measurements are possible when the load is directed right on the sensors. That is why in real-life monitoring, it is essential to consider the direction of traffic. Scientists also verified that temperature plays a major role in the deformation of asphalt: all measured values were lower in fall than in warm summer.

A key part of the experiment was monitoring actual traffic. About 3.15 million cars pass through the point where the measurements were taken in a year, and over 23% of them are heavy trucks. Physicists determined which types of trucks impact the roadway the most and calculated that in 33% of cases, a passing truck deforms the asphalt by 0.3 mm per meter.

TPU Opens Research Center for Petrochemistry and Technology

Tomsk Polytechnic University (TPU) has opened a new subdivision based on the School of Earth Sciences and Engineering. The subdivision will unite a wide range of research areas and will allow carrying out more works for the benefit of industrial partners of the university.

According to Natalya Guseva, Director of the TPU School of Earth Sciences and Engineering, the opening of a new centre in the structure of the School and the reorganization of the Innovation Research Laboratory for Drilling, Washing and Slurry Solutions are caused by the development of staff’s competences.

“At the moment, the laboratory staff work in new research areas and can solve a quite wider range of tasks. It will allow the TPU School of Earth Sciences and Engineering to enhance cooperation with industrial partners and positioning on the market for services, as well as to take part in more large-scale projects, where different competencies are required,” Natalya Guseva says.

Konstantin Minaev, Head of the Innovation Research Laboratory for Drilling, Washing and Slurry Solutions, will lead the new centre. The subdivisions of the centre are located in the TPU academic buildings No. 2, 19 and at the TPU Science Park. JSC Tomskneft VNK, an industrial partner of TPU, contributed to the renovation and re-equipment of premises in academic building No. 19.

“First of all, I would like to thank all the team, as it is a serious step on team building for solving serious tasks at the frontier of the petroleum industry. The centre opening will allow expanding the range of research and engineering works in petrochemistry due to the new and up-to-date equipment, interdisciplinary contacts and query enhancement from industrial partners. It is a reply to the question on breaking down barriers among university laboratories. The most important is that the Center opens additional opportunities for students: they can choose a trajectory, come to the place where new projects are born, use the newest equipment,” Andrey Yakovlev, Acting Rector of TPU, said at the center opening.

The Research Center for Petrochemistry and Technology will unite five areas: oilfield chemistry, drilling fluids, slurry solutions, reservoir physics, the chemistry of petroleum and petroleum products. The skeleton staff is the laboratory staff, however, new experts, as well as young scientists: graduates and postgraduates, including international ones, will be invited.

“We can carry out large-scale projects, we possess accumulated experience that will allow us to holistically solve serious tasks both in a research area and for industrial partners. I am sure we will have interesting work ahead,” Konstantin Minaev, Head of the Center for Petrochemistry and Technology, addressed the staff.

The Center is planned to carry out both research and industrial projects, however, the key point will be focused on cooperation with industrial partners. To equip the Center on the program of renewal of instruments, there was purchased high-class equipment including a rheometer and tensiometer worth over 15 million rubles.

There was no equipment of such level for research in oilfield chemistry at TPU. It will allow our staff members to become participants of more serious projects for the benefit of industrial partners and will allow our students to master the devices during their study time,” Konstantin Minaev explained.

In total, there was spent over 70 million rubles during several years for installation and purchasing miscellaneous equipment for different units of the Center.

“Today, we see the result of the cooperative path that was travelled by our laboratories in approaching and building relations with each other. At the moment, different subdivisions can say that they can implement large-scale projects for the industry,” Artem Boev, TPU Vice-Rector for Technological Development and Entrepreneurship.

EdUHK Scholar co-authors article published in Nature Climate Change

A team of leading climate social scientists, including a chair professor at The Education University of Hong Kong (EdUHK), argues that influential studies that attempt to quantify different countries’ “fair shares” of climate action have put forward a biased and oversimplified view of what is primarily a political and ethical discussion.

The Perspective piece, “Ethical choices behind quantifications of fair contributions under the Paris Agreement,” published in the pre-eminent academic journal Nature Climate Change, comes as the world’s governments are expected to release new national plans for climate action ahead of climate negotiations later this year in Glasgow, Scotland, and defend them as “fair and ambitious”.

One of the article’s co-authors is Professor Paul G. Harris, Chair Professor of Global and Environmental Studies in the Department of Social Sciences at EdUHK, who has spent three decades conducting research and writing about climate justice and governance.

The piece evaluates a selection of recent effort-sharing studies to determine whether they are explicit about the ethical choices underlying their analyses. Reviewing sixteen studies that quantify equitable effort sharing between countries under the Paris Agreement, the authors find that nearly two-thirds (10 studies) present themselves as neutral or value-free, despite being limited to a small and biased subset of ethical perspectives on effort-sharing that tend to favour wealthier countries.

“It is widely assumed that climate change is a technical or political problem. It is more accurate to conceive of it as a normative problem in which disagreements about what is just, fair and equitable crowd out co-operation on social and technological solutions,” said Professor Harris.

Sivan Kartha, Senior Scientist at the Stockholm Environment Institute added, “Studies that incorrectly purport to be neutral and objective are not just misleading, they can even be harmful. In this case, they can set unrealistic expectations about what countries might be expected to contribute to a global climate effort. Even if it’s not intentional, one can imagine the problems caused by a body of literature with a consistent bias toward wealthier and against poorer countries.”

In particular, the ‘grandfathering’ of emissions, where countries argue their status as high emitters is a justification for continued high emissions, should not be included in equity assessments of global climate action. This is a key source of the systematic bias in favour of wealthier, higher emitting countries.

Other studies claim objectivity by averaging a spectrum of equity approaches, commonly choosing a subset that excludes important ethical concepts. For instance, when many analyses quantify a country’s capacity to allocate resources to a global climate effort, they routinely treat a dollar earned by a poor citizen as wholly equivalent to a dollar earned by a rich citizen.

Many indicators ranking nations’ efforts to address climate change “say they’re about equity, but there’s still a systematic bias in favour of the biggest historical polluters. As we review efforts in the ‘global stocktake’ of the Paris Agreement, these kinds of indicators must be transparent.  Otherwise, they are anti-equity,” said Timmons Roberts, Professor of Environmental Studies and Sociology at Brown University and Director of the Climate Social Science Network.

“Studies should be explicit about the ethical and moral implications of their underlying assumptions, and equity assessments of countries’ climate action must be based on ethically defensible principles, such as responsibility, capacity and need,” said Dr Kate Dooley, Research Fellow at the University of Melbourne and lead author of the study.

Professor Harris added: “This article helps to reinforce what we already know from other aspects of life: reliance on statistical indicators can result in potentially unjust outcomes. It’s more important than ever to view the ethical challenges of climate change holistically and qualitatively.”

The authors propose new guidelines that emphasise transparency in communicating the ethical underpinnings of assessments of climate action and suggest guidelines for developing policy-relevant — but not ethically neutral — equity research, which includes studies of equitable distribution of climate efforts should not claim value-neutrality; analysis needs to ensure that the losses of those who are potentially marginalised remain clearly visible, and analytical work should aim to inform rather than supplant the political process.

President University and University of Indonesia discuss joint activities

To sustain the collaboration that has existed since 2019, President University (PresUniv) and University of Indonesia (UI) again held a group discussion. This time the discussion took place online via the Zoom platform on Monday (7/6). This discussion was held to discuss the activities between PresUniv and UI that will be carried out soon.

This discussion resulted in various activities agreed upon by both universities, including are joint webinars, joint research, student or lecturer exchange, and inter-campus visit. The event details, such as the implementation date and the series of activities, will be discussed further to adjust to the current conditions.

In this discussion,the Vice-Rector for Human Resources and Assets, Prof. Dr. Ir. nDedi Priadi, DEA, and Head of Sub-Directorate for Academic and Government Cooperation, Eko Sakapurnama, represented UI. Meanwhile, from PresUniv, the Vice-Rector I for Academic and Student Affairs, Handa S. Abidin, and Vice-Rector II for Resources, Dr. Dra. Fennieka Kristianto, were present.

In addition, there were also deans, heads of study programs, and representatives from various bureaus in PresUniv. Among them, Academic Bureau, Dean of the Faculty of Business, Partnership Bureau, Head of the Law Study Program, Internship and Career Center (ICC) Bureau, to Dean of the Faculty of Engineering.

HKBU secures funding from RGC Theme-based Research Scheme to build platform technologies for symbiotic creativity

A research project led by Hong Kong Baptist University (HKBU) titled “Building Platform
Technologies for Symbiotic Creativity in Hong Kong” has been awarded HK$52.8 million in research funding from the Theme-based Research Scheme (11th round) under the Research Grants Council (RGC) for a five-year project. This is the first time that major funding has been allocated by the RGC for an art-tech project.

The research team will develop platform technologies for symbiotic creativity, providing unlimited art content for humans, including an art data repository, an artificial intelligence (AI) creative algorithm system, a research theatre, a digital art and policy network, and some unique and creative application projects, to usher in a new era of the art technology.

 Led by Professor Guo Yike, Vice-President (Research and Development), and Professor
Johnny M Poon, Associate Vice-President (Interdisciplinary Research), at HKBU, the research team will develop an immersive and interactive extended reality (XR) platform to capture human data during the artistic creation and appreciation process, which includes the cognitive and physiological data of artists and the audience, such as brain waves, body temperature and heart rates, gait and movements, etc. The platform will then convert the data into the descriptors of cognition, emotions, and behavioural patterns.

The researchers will associate and link the artworks with the descriptors to build a comprehensive and extensive data repository for artificial intelligence model training. It will enable machines to learn human aesthetics, instead of mimicking art created by humans.

 The platform will also enable the audience to immerse themselves in a virtual world. They will be surrounded by images, sounds, etc, and have new artistic experiences. In addition, the immersive and interactive XR platform will be equipped with a number of sensing devices, which will help the artists to go beyond the traditional forms and boundaries and communicate and interact with the audience in new ways.

“This research project has secured funding from the RGC, demonstrating that Hong Kong
attaches great importance to the development of artistic and creative technologies based on AI. This project stands at the forefront of the arts and science nexus, harnessing the power of science and technology to advance human and AI interaction in art creation. It will foster a new direction in art created by both humans and machines,” said Professor Guo.

 “We will spare no effort in building a world-class AI art creation platform, and it will
drive a new revolution that transforms the creative and cultural industries. It
will enable Hong Kong to assume a leading position in art-tech on the global stage,”
he added.

 Under this project, HKBU will launch three application projects: the Super AI artist – the
world’s first “Combined Music and Art Biennale”, which will host multidisciplinary musical works and artworks jointly created by humans and AI; Shared Mind and Empathetic AI – a concert series featuring a three-way collaboration between performers, the audience and machines; and Symbiotic Opera – a new form of opera that integrates with immersive XR technology, and it will be jointly created by humans and machines in an immersive virtual
world.

 Members of the multidisciplinary research team led by HKBU include cognitive scientists,
AI and data scientists, media scientists, ethicists and art policy scholars from Yale University, the University of Cambridge, Imperial College London, the University of Kent, Tsinghua University, the University of Hong Kong and City University of Hong Kong. The research team will also collaborate closely with industrial and musical partners, including Huawei, Microsoft, SenseTime and Opera Hong Kong. 

Sunway PAIR organizes a virtual forum to address concern on the pandemic’s economic impact

Upon being hit by the wave of pandemic for over a year, it has become increasingly crucial for the nation to adapt to the new normal. However, many businesses and workforces
were and still are affected by lockdowns and social restrictions imposed to flatten the curve. The World Bank stated that this pandemic has caused the deepest recession since the Second World War.

Pandenomics’ represents the union between pandemic and economics and it has become evident that COVID-19 has gravely impacted the global economy.

Sunway Project for Asian and International Relations (Sunway PAIR) club has conducted an
open-to-public virtual forum, “Pandenomics: Global Economic Sentiment to COVID-19”, to address the public’s concern on the pandemic that has adversely affected multiple industries.

This forum aims to provide a platform for future business owners to learn from industry
leaders on business sustainability during unprecedented times. It also intends to create a space for individuals anxious about the future of their careers and gain insight on how to survive and succeed in a competitive employment market.

“With the shift in teaching and learning trends moving towards entrepreneurship, we need
to have graduates who not only seek employment but who can also help create jobs too. Current students, graduates, and many of you in the workforce need to be retrained and upskilled to ensure that you stay relevant and be up-to-date according to the shifts in the job environment,” said Professor Elizabeth Lee, CEO of Sunway Education Group in her welcoming address.

“In economic terms, the biggest lesson from this pandemic is: if you don’t control COVID-19, COVID-19 will control you. Because of the very rapid vaccination in the wealthy and developed countries, they are beginning to control it and recover,” said Tan Sri Andrew Sheng, Pro-Chancellor of Bristol University & Distinguished Fellow of Asia Global Institute
during his keynote.

He added that the pandemic had widened the gap not only between rich and poor nations but also among businesses and members of society. The rich and elite have better
access to resources, allowing them to work and do business online while the small
traders and daily-wage earners are struggling.

The forum was divided into two parts where the first session was titled ‘Business Pivot: A
Survival Tool During Pandemic,’ and was centred on business sustainability and survival. The panellists who attended were Sarena Cheah Yean Tih, Executive Director of Sunway Group; Nadiah Wan, CEO & Group Chief Executive Officer of Thomson Hospital Kota Damansara; Smita Kuriakose, Senior Economist in the Finance, Competitiveness and Innovation Global Practice, World Bank; Vimala Murugan, Deputy Senior Director, Industrial Development Division, Ministry of International Trade and Industry; Nicholas Khaw Hock-Lu, Head of Research, Economist, Khazanah Nasional Berhad (KNB), and was moderated by Jason Jonathan Omar, Co-founder and CEO of Talent Shop Co.

The second session was titled ‘Graduation = Unemployment? Labour Market Under COVID-19 Crisis’ and emphasized on the unemployment issues in Malaysia. The panellists
attended were Chook Yuh Yng, Chief Growth Officer, Careers and Connect Platform, SEEK Asia; Vinesh Naidu, Human Capital Leader of PwC Malaysia; Clayton Tan Ju Chiae, Senior General Manager, Head of Organization Development of Sunway Group; Sophia Ang Wui Jiun, Executive VP, Head, Talent Attraction and Workplace Futurisation, Maybank; Danial Abdul Rahman, Director of the CEO’s office, Sunway Education Group, and was moderated by Kelvin Tay, Founder and podcast host of Renegade Radio, Podcast Host.

“During the pandemic, we saw how this lack of trust in institutions caused significant
harm. That is why the challenge for us is to restore hope in the people, to trust institutions, that the Federal Constitution is still worthy of upholding, that our system of parliamentary democracy can get us out of this pandemic,” said Yang Amat Mulia Tunku Zain Al-‘Abidin, Trustee of Jeffrey Cheah Foundation, Founding President of Institute for Democracy and Economic Affairs during his closing address.

UiTM graduates join the first all-women Data Science and Artificial Intelligence department in MDEC

Nabilah Mohd Akhir and Farah Nabillah Mohamed Jizad, both graduates of Master of Data Science, Faculty of Computer and Mathematical Sciences (FSKM) of Universiti Teknologi MARA (UiTM) join the newly-formed Data Science and Artificial Intelligence (AI) department in Malaysia Digital Economy Corporation (MDEC). This all-women team will continue MDEC’s constant drive to leverage new technologies to bring relevant and market-driven products and services.

The announcement was made by Surina Shukri, CEO of MDEC on 9 March 2021, in conjunction with International Women’ Day. Surina was very pleased that MDEC continues to bridge the gender divide reflecting their commitment to ensuring shared prosperity for all, in line with the visions of the Malaysia Digital Economy Blueprint (MyDIGITAL).

The appointment is a continuation of the Digital for Malaysia Associate Programme (DMAP) which provides opportunities for new graduates in the fields of digital technology, data science, and AI to gain digital work experience in these fields.

The Faculty of Computer and Mathematical Sciences (FSKM), UiTM Shah Alam is committed to the university’s vision in providing frontier technology knowledge to bumiputra and the nation. Among the programs offered is the Master of Data Science, which was first offered in September 2017, and to date, the program has around 50 graduate students.

Students from the Masters in Data Science program were trained to transform a sea of data into actionable insights and solve vexing problems through modeling, statistics, analytics, and mathematics skills and help make objective decisions for organisations. The appointment proved that graduates from the Masters in Data Science have high employability prospects and with the full support from the Ministry of Communications and Multimedia (KKMM).

Russian and Italian scientists discover new substance that can kill cancer cells

Specialists of the Center of Medical Chemistry of Togliatti State University in collaboration with colleagues from Saint Petersburg State University and University of Florence (Università degli Studi di Firenze) have found a new pro-apoptotic agent – a substance capable to suppress the growth of malignant tumours.

In March of this year, the specialists of  TSU, SPbSU and UoF conducted a joint research study that resulted in new chemical substances from the group of sulfonamides that inhibit the activity of carbonic anhydrase (CA).

Carbonic anhydrases (CAs) – is an important class of enzymes in the human body that are responsible for the regulation of various physiological processes, ensuring the constancy of the internal environment of the cell in terms of CO2 level and pH –balance. A cancer cell, unlike a normal one, has various mechanisms for survival, one of them being an increased expression of carbonic anhydrase.

In an unfavourable environment, a cancer cell begins to intensively express (synthesize) carbonic anhydrase on its surface, which “acidifies” everything around, killing healthy
cells and creating conditions for tumour growth.

In search of new carbonic anhydrase inhibitors, scientists from two countries received an unexpected result.

” This time we tried a new class of inhibitors, which should have had a slightly different
mechanism of carbonic anhydrase inactivation. Unfortunately, our substances did not work according to this mechanism, but it turned out that one of the compounds had an activity that did not correlate with the activity of carbonic anhydrase. This is how we discovered a new pro-apoptotic agent – ” Alexandr Bunev, director of the Center for Medical Chemistry, said.

Apoptosis is one of the most conservative mechanisms of cell death, which is necessary for maintaining cellular homeostasis*. In a normal cell, it is triggered in the case of some disorders or damage, while the cancer cell does everything to suppress apoptosis.

” A cancer cell does not need apoptosis, on the contrary, it acquires some resistance to this
process due to incorrect mutations and divisions. From this point of view, apoptosis inducers – chemicals that can affect also tumour cells and induce (cause) apoptosis in them – represent a fundamentally interesting mechanism of action in modern antitumor, including targeted drugs, ” Alexander Bunev explains.

Scientists conducted a series of tests to confirm that under the influence of the new compound, cancer cells entered deep apoptosis. Studies have also allowed experts to assume that the resulting substance is able to intercalate (penetrate) into Deoxyribonucleic acid (DNA).

This gives a certain failure in the division, and the cell is forced to go into apoptosis, even if it has some algorithms for bypassing it, –Alexander Bunev says.

The results of the scientists’ joint work from Togliatti, St. Petersburg and Florence are published in the European Journal of Medical Chemistry (Q1), which provides coverage to
the original research works in the main fields of medicinal chemistry.