HKBU’s discovery of new coral and nudibranch species reflects Hong Kong’s rich marine biodiversity

Biologists from Hong Kong Baptist University (HKBU) have discovered in Hong Kong waters a new species of hard coral and two new species of nudibranch, a type of marine mollusc, that have never been identified anywhere else in the world. The discoveries of new species from these commonly seen animal groups are a vivid reflection of Hong Kong’s rich marine biodiversity.

The new marine species were identified by research teams led by Professor Qiu Jianwen, Professor of HKBU’s Department of Biology. The descriptions of the new coral and nudibranch species were published in the academic journals Zootaxa and Zoological Studies, respectively.

The new coral species belongs to the genus Tubastraea, which is commonly known as sun coral due to its bright orange polyps (individuals making up the colony) and the circle of tentacles that surround its mouth. HKBU biologists discovered the new species while conducting underwater surveys at the Breaker Reef in the eastern waters of Hong Kong in the summer of 2020.

The team named the coral Tubastraea megacorallita, with “mega” and “corallite” meaning “big” and “skeletal cup”, respectively. The species name reflects the fact that it has the biggest and most structurally complex corallite among the eight recognised Tubastraea species around the world. This species forms small colonies of between three and 12 polyps, and they share a common calcareous skeleton.

Sun corals are different from most reef-building corals, as they do not host symbiotic algae that produce energy via photosynthesis. Instead, these corals gain energy and nutrients by capturing small animals called zooplankton from seawater using their tentacles. While reef-building corals in Hong Kong typically inhabit shallower waters up to a depth of 10 metres, sun corals live in deeper waters at a depth of between 10 and 30 metres.

“Although 98 species of hard coral have been recorded in Hong Kong, the last time a new coral species was discovered in Hong Kong waters was in 2000. It is in over around 20 years a new hard coral species discovered and named in Hong Kong,” said Professor Qiu.

Nudibranchs, commonly known as sea slugs, are gastropod molluscs that only have a shell during their larval stage. They are eye-catching animals, and they can often be spotted on coral reefs due to their vivid body colour patterns.

The HKBU team also discovered in Hong Kong waters two coral-eating species of nudibranch, both belonging to the genus Phestilla that has only nine recognised species prior to these discoveries. One of them, named Phestilla goniophaga, was collected from Sharp Island and Chek Chau. The word “goniophaga” derives from the name of the host coral, “Goniopora”, which is commonly known as flowerpot coral, and the Latin word “phaga”, which means “eat”.

Phestilla goniophaga is rather big, and its body is around three centimetres long. It can be distinguished from other species of the genus by the large number of long finger-like, brown and white striped projections called cerata, and the white rounded hump on its back. The hump resembles the host coral’s mouth, while the cerata resemble the coral’s tentacles. This mimicry makes it difficult for its potential predators, such as fish, to spot them. Its egg masses, however, are bright orange in colour and they can normally be found glued to the coral skeleton.

The other newly discovered nudibranch species is smaller in size, and its body is less than one centimetre long. It lays eggs and feeds on the tissue of the leaf coral Pavona decussata. It has a white body with brown stripes and exhibits excellent mimicry against the colour pattern of its coral host. It was named Phestilla fuscostriata, with the species epithet adopting the Latin words “fuscus” and “striatus”, which mean “brown” and “streaky”.

This new species was discovered while culturing the leaf coral samples collected from Sharp Island during a study of coral bleaching mechanisms. The HKBU team discovered the new nudibranch species and its crescent-shaped white egg masses after noticing the wounds on the coral surface caused by its feeding.

While the seas around Hong Kong are only 1,651 square kilometres in size, the territory has around six thousand marine species – one-quarter of all the marine species recorded in China.

The work conducted by Professor Qiu’s team highlights the rich biodiversity found in Hong Kong, and reflects the urgent need to train local young talent to implement the Hong Kong Biodiversity Strategy and Action Plan.

HKBU study finds strong association between PM2.5 and neurological disorders

A comprehensive, systematic meta-analysis conducted by Hong Kong Baptist University (HKBU) scientists found a significant association between exposure to PM2.5, i.e., fine particulates with equivalent diameters of less than 2.5 microns suspended in the air, and neurological disorders.

These include stroke, dementia, Alzheimer’s disease, Parkinson’s disease and autism spectrum disorder (ASD). Neurological disorders are the leading cause of disability and the second leading cause of death worldwide, posing serious challenges to global health.

The paper with the study’s finding was published in the academic journal Science of the Total Environment and has become the top 1% highly-cited paper worldwide by citation in the field of Environment and Ecology, according to Essential Science Indicators (ESI).

As systematic reviews and meta-analyses on the association between PM2.5 exposure and neurological disorders have been limited so far, the HKBU research team, led by Professor Ken Yung Kin-lam, Professor of the Department of Biology of the University, analysed a total of 1,645 articles published by June 2018 and identified 80 eligible studies that covered a population of more than 6.33 million from 26 countries or regions in all continents except Antarctica.

Previous meta-analyses of a similar nature covered at most seven countries, and nearly all of them were lightly polluted. In contrast, HKBU’s study covered countries and regions known to have more serious air pollution problems, such as Chile, China and India.

After a series of statistical analyses of the data published in the selected studies, the research team used odds ratio (OR) to represent the association between PM2.5 exposure and the risk of different neurological disorders. Odds ratio, commonly used in public health analysis, is a measure of association between an exposure and an outcome. An odds ratio value of 1 indicates that exposure does not affect the odds of an outcome; a value of over 1 means exposure is associated with higher odds of an outcome.

The results revealed that exposure to PM2.5 in general increases the risks of stroke and stroke mortality, with the risk associated with long-term exposure more significant than with short-term exposure. It also showed that the risk of stroke in heavily polluted areas is higher than that in lightly polluted areas.

Analysis results of the association between PM2.5 exposure and the risks of developing other neurological disorders were studies. The results revealed that PM2.5 exposure is strongly associated with increased risks of Alzheimer’s disease, ASD, Parkinson’s disease and dementia.

PM2.5 is typically made up of heavy metals, organic carbon and polycyclic aromatic hydrocarbons suspended in the air. According to studies, some of the tiny particles and soluble components can enter the bloodstream by many pathways, such as crossing the blood-brain barrier and gaining access to the central nervous system. These particles can induce inflammation, death of cells and DNA damage.

“While various hypotheses were suggested on the underlying mechanisms of how PM2.5 causes different types of neurological disorders, it remains an area with many unknowns for biomedical scientists to explore. More vigorous research endeavours are required before we can fully understand the mechanisms, based on which we can formulate effective environmental and public health strategies in response,” said Professor Yung.

7 September is the 2nd International Day of Clean Air for blue skies designated by the United Nations General Assembly, with the theme “Healthy Air, Healthy Planet”, which emphasises the health effects of air pollution.

“The International Day of Clean Air for blue skies reminds us of the urgency for national governments and the international community to collaborate and take swift, effective actions to improve air quality, given its extensive health implications. Our study made it clear that PM2.5 exposure, a typical indicator of air pollution, is closely associated with many neurological disorders, and thus improving air quality will be a direct response to this public health challenge,” said Professor Yung.

BOC–HKBU Chinese medicine community scheme offers free rehabilitation services to low-income stroke patients

Hong Kong Baptist University (HKBU) and the Hong Kong Sheng Kung Hui (HKSKH) Welfare Council have received a generous donation from the Bank of China (Hong Kong) (BOCHK) for the three-year “BOC–HKBU Chinese Medicine Community Stroke Prevention and Rehabilitation Scheme”.

The Scheme provides free Chinese medicine rehabilitation treatments to 500 eligible low-income stroke patients and it also offers free preventive treatments and tracking assessments to 1,200 people who have a medium to high risk of having a stroke.

The launch ceremony for the Scheme was held on 29 July on the HKBU campus. Dr Cheung Wai-lun, Project Director of the Chinese Medicine Hospital Project Office, the Food and Health Bureau; Mr Jimmy Sun, General Manager of the Institutional Business Department, BOCHK; Professor Alexander Wai, President and Vice-Chancellor of HKBU; and Dr Lee Ching-yee, Director of HKSKH Welfare Council Limited, officiated at the ceremony.

In his speech, Professor Alexander Wai said the School of Chinese Medicine (SCM) at HKBU launched Hong Kong’s first full-time Chinese medicine undergraduate programme funded by the University Grants Committee in 1988. Since then, SCM has been providing Chinese medicine services to the community and promoting Chinese medicine education, research and healthcare services in Hong Kong.

“Apart from reducing public healthcare expenses, improving the quality of life of stroke patients, and increasing the success rate of rehabilitation initiatives, the BOC-HKBU Chinese Medicine Community Stroke Prevention and Rehabilitation Scheme can also serve as a good example of how we can construct a community medical service management model based on collaboration between the Chinese medicine sector and the community,” he said.

Mr Jimmy Sun said: “BOCHK has all along taken a proactive approach to its social responsibilities, and it has continuously supported primary healthcare and the development of Chinese medicine. We have maintained a long-term partnership with HKBU in the area of Chinese medicine, including a donation to its School of Chinese Medicine to establish the Bank of China (Hong Kong) Chinese Medicines Centre in 2003, and the offering of Chinese medicine supplements for pneumonia prevention to frontline medical staff in collaboration with the University’s Anti-SARS Action Group in the fight against the SARS outbreak. In the future, BOC will continue to support the development of Chinese medicine so that more Hong Kong citizens can benefit.”

Dr Lee Ching-yee said the HKSKH Welfare Council has worked with SCM through a medical-community collaboration to set up community clinics since 2017. In particular, teachers and students from SCM visited elderly people in the Kowloon City district to follow up and deal with their physical pain problems. “The community clinics set up by this Scheme officially opened in January this year. In just half a year, the project team received more than 100 applications. With professional treatments administered by Chinese medicine practitioners and follow-ups organised by social workers, many successful cases have been observed,” she said.

Mr Wong Hon-kwong, a beneficiary of the Scheme who received half a year of free Chinese medicine and acupuncture services, said: “I could not open my left palm before, but I can now. My friends can see my progress.” His wife also said that he has improved his mobility. As a result,  he can now walk more smoothly, and these developments have boosted his self-confidence.

The BOC–HKBU Chinese Medicine Community Stroke Prevention and Rehabilitation Scheme, which started in October 2020 and runs until September 2023, mainly serves people aged 60 or above who are Comprehensive Social Security Assistance or Old Age Living Allowance recipients, or stroke patients from low-income families. Stroke patients under the age of 60 who are in need of support can also join the Scheme after an assessment by social workers or a referral from one of the SCM clinics.

Under the Scheme, experts from SCM will form treatment teams and formulate a six-month treatment programme for stroke patients.

Patients will receive free Chinese medicine, acupuncture and massage treatments two to three times a week, up to 72 times in total. SCM will arrange for Chinese medicine practitioners to visit the patients, or alternatively, the practitioners will invite them to receive their treatments at the elderly centres of the HKSKH Welfare Council. It is expected that about 500 people will benefit from the Scheme. Furthermore, the Scheme will provide counselling and support services for older stroke patients and their family members.

In addition, SCM clinics and the HKSKH Welfare Council’s elderly centres will set up health management stations for stroke patients, with SCM offering training to suitable older people who can then go on and serve as Chinese medicine senior ambassadors for stroke prevention. Using a soon-to-be-launched website, the ambassadors will assess the risk of stroke in other older people in the community and promote stroke prevention messages.

Around 1,200 older people with a moderate to high risk of stroke will be referred to the HKSKH Welfare Council’s elderly centres to undergo a one-year preventive treatment programme and follow-up assessments. The website will also provide recommendations on balanced diets and appropriate exercises for people with a low to medium risk of stroke, and alert high-risk individuals to seek medical treatment.

Those who are interested in participating in the Scheme can call 6533 9972 or 2333 1854 for any enquiries, or they can complete the following online form: https://docs.google.com/forms/d/e/1FAIpQLSdCoJwAYWDzOpxXvzkOYkRx0_7xB8GvZeuscb7B98jtiwItGA/viewform

HKBU secures funding from RGC Theme-based Research Scheme to build platform technologies for symbiotic creativity

A research project led by Hong Kong Baptist University (HKBU) titled “Building Platform
Technologies for Symbiotic Creativity in Hong Kong” has been awarded HK$52.8 million in research funding from the Theme-based Research Scheme (11th round) under the Research Grants Council (RGC) for a five-year project. This is the first time that major funding has been allocated by the RGC for an art-tech project.

The research team will develop platform technologies for symbiotic creativity, providing unlimited art content for humans, including an art data repository, an artificial intelligence (AI) creative algorithm system, a research theatre, a digital art and policy network, and some unique and creative application projects, to usher in a new era of the art technology.

 Led by Professor Guo Yike, Vice-President (Research and Development), and Professor
Johnny M Poon, Associate Vice-President (Interdisciplinary Research), at HKBU, the research team will develop an immersive and interactive extended reality (XR) platform to capture human data during the artistic creation and appreciation process, which includes the cognitive and physiological data of artists and the audience, such as brain waves, body temperature and heart rates, gait and movements, etc. The platform will then convert the data into the descriptors of cognition, emotions, and behavioural patterns.

The researchers will associate and link the artworks with the descriptors to build a comprehensive and extensive data repository for artificial intelligence model training. It will enable machines to learn human aesthetics, instead of mimicking art created by humans.

 The platform will also enable the audience to immerse themselves in a virtual world. They will be surrounded by images, sounds, etc, and have new artistic experiences. In addition, the immersive and interactive XR platform will be equipped with a number of sensing devices, which will help the artists to go beyond the traditional forms and boundaries and communicate and interact with the audience in new ways.

“This research project has secured funding from the RGC, demonstrating that Hong Kong
attaches great importance to the development of artistic and creative technologies based on AI. This project stands at the forefront of the arts and science nexus, harnessing the power of science and technology to advance human and AI interaction in art creation. It will foster a new direction in art created by both humans and machines,” said Professor Guo.

 “We will spare no effort in building a world-class AI art creation platform, and it will
drive a new revolution that transforms the creative and cultural industries. It
will enable Hong Kong to assume a leading position in art-tech on the global stage,”
he added.

 Under this project, HKBU will launch three application projects: the Super AI artist – the
world’s first “Combined Music and Art Biennale”, which will host multidisciplinary musical works and artworks jointly created by humans and AI; Shared Mind and Empathetic AI – a concert series featuring a three-way collaboration between performers, the audience and machines; and Symbiotic Opera – a new form of opera that integrates with immersive XR technology, and it will be jointly created by humans and machines in an immersive virtual
world.

 Members of the multidisciplinary research team led by HKBU include cognitive scientists,
AI and data scientists, media scientists, ethicists and art policy scholars from Yale University, the University of Cambridge, Imperial College London, the University of Kent, Tsinghua University, the University of Hong Kong and City University of Hong Kong. The research team will also collaborate closely with industrial and musical partners, including Huawei, Microsoft, SenseTime and Opera Hong Kong. 

Lessons from the COVID pandemic

The COVID-19 pandemic has transformed our lives in a multitude of ways, and it has created new, diverse challenges among societies around the world. To help examine the implications of the pandemic, HKBU held an international symposium with the theme “Transnational and Transdisciplinary Lessons from the COVID-19 Pandemic” on 20 and 21 May. Researchers, academics and participants from Hong Kong and overseas gathered in person or virtually to exchange ideas and discuss the global and local issues related to the pandemic.

Organised by the Department of Government and International Studies, in association with the Department of Sport, Physical Education and Health and the David C. Lam Institute for East-West Studies, the two-day conference was a key event in the calendar of celebratory activities organised for the 50th anniversary of the Faculty of Social Sciences.

The symposium brought together over 30 speakers from Australia, France, Hong Kong, Singapore and the UK, as well as a range of stakeholders from outside of academia. Three discussion panels and four matched parallel sessions were delivered with speakers exchanging ideas on a wide range of topics, from the economic and financial consequences of the pandemic to governance and environmental health issues.

Dr Huw Wiltshire, former National Performance Director of the Welsh and Russian Rugby Unions, gave a keynote speech on the pandemic’s impact on top athletic performance. He not only discussed the importance for elite athletes to maintain specific types of training in the current times, but he also raised questions around the survival of sport in a world where human contact is restricted.

The event closed with a roundtable discussion on the future of the post-pandemic environment. The panellists highlighted that the pandemic has accelerated scientific progress, but they also stressed the need for societies to strike a balance between exercising precaution and facilitating innovation. Recognising that new opportunities can emerge out of crises, the speakers shared insights into potential areas of interdisciplinary research and expressed optimistic perspectives on humans’ capacity for adaptation, innovation and ingenuity.

HKBU and Cornell University jointly develop a novel targeted therapy for breast cancer

Researchers from Hong Kong Baptist University (HKBU), in collaboration with Cornell University, have developed a novel targeted therapy for triple-negative breast cancer (TNBC) that uses a specially-designed nano-carrier to deliver the Chinese medicine compound gambogic acid (GA).

The invention enhances the anti-cancer effect of GA and reduces its damage to off-target organs. The invention has the potential to become a more effective therapeutic option for TNBC.

The study was supported by the Vincent and Lily Woo Foundation, and the research findings have been published in the international medical journal Frontiers in Oncology.

GA as a breast cancer treatment and its limitations

TNBC accounts for 10-24% of all breast cancer cases and it also grows and spreads faster than other types of breast cancer. There are limited treatment options for TNBC and it has a high risk of recurrence and metastasis. In the advanced stage of the disease, the five-year relative survival rate is only about 12%.

GA is a herbal compound isolated from a dry, brownish resin called gamboge, which is derived from Garcinia hanburyi, a plant with a long history of medicinal use in Southeast Asia.

Previous studies have shown that GA can inhibit the growth of cancer cells. However, its clinical application is limited by the fact that it is rapidly eliminated from the circulation system and has poor water solubility, which makes it difficult for GA to reach the cancer cells. Furthermore, high dosages of GA can cause damage to off-target organs due to its toxicity.

Nano-carrier increases treatment efficacy of GA

In the search for a more effective treatment protocol for TNBC when compared to existing options, Professor Bian Zhaoxiang, Director and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies of the Clinical Division of HKBU’s School of Chinese Medicine (SCM) and Dr Kwan Hiu-yee, Assistant Professor of the Teaching and Research Division of SCM, together with the research team of Professor Chu Chih-Chang at Cornell University, designed a novel nano-carrier to enhance GA’s efficacy as a TNBC treatment and reduce its off-target toxicity.

The researchers made a bio-degradable nano-carrier out of polyester urea urethane (PEUU), and they decorated it with folate (also known as vitamin B9) and arginine (an amino acid). Folate receptors are highly expressed in TNBC cells, and they can serve as a target for therapy. Arginine is a positively charged amino acid, and it can attract the nano-carrier to the negatively charged tumour surface. These features enable the nano-carrier to target and deliver GA effectively to TNBC cells.

Treatment efficacy tested in mice

The research team tested the efficacy of the GA-loaded nano-carrier as a TNBC treatment in a series of mouse experiments. Two groups of mice with TNBC were treated with the same dosage of GA, one in the form of the GA-loaded nano-carrier, and the other in the form of free GA. After 17 days of treatment, the average reduction in tumour weight of the GA-loaded nano-carrier group was 67.6% higher than the free GA group. The results showed that the GA-loaded nano-carrier is more effective at shrinking the tumours than the free GA.

In addition, the group treated with the GA-loaded nano-carrier had 0.23 μg/mL of GA in their tumours two hours after injection, and the tumour GA concentration of the GA-loaded nano-carrier group was three times of the free GA group, showing that GA is being delivered to TNBC cells more effectively with the nano-carrier. Also, the concentration of GA in the plasma of the GA-loaded nano-carrier group two hour after injection was nearly three times of the free GA group, showing that the GA carried by the nano-carrier stays in the circulation system for longer.

Reduced off-target damage to other organs 

Furthermore, when compared with free GA, the GA delivered by the nano-carrier caused less damage to the off-target organs of the mice including their hearts, livers and lungs. It also caused minimal damage to their kidneys and spleens as relatively low levels of GA were detected in these two organs.

“As demonstrated in our study, the novel nano-carrier for GA offers many benefits when it comes to treating TNBC,” said Dr Kwan Hiu-yee.

“The application of nanotechnology in this study modernises the delivery of Chinese medicine, thereby enhancing its therapeutic efficacy. We believe that our nano-carriers have great clinical potential to treat TNBC and other types of cancer,” said Professor Bian Zhaoxiang.