CUHK leads international conversation at APAIE 2026

The “Study in Hong Kong” brand shone brightly in February, as The Chinese University of Hong Kong (CUHK) welcomed over 3,500 delegates from 72 countries and regions to the Asia‑Pacific Association for International Education (APAIE) 2026 Conference and Exhibition – one of the world’s three most prominent international education conferences.

Over five days, delegates explored the future of higher education under the theme “Asia‑Pacific Partnerships for the Global Good”. Across some 130 sessions, universities and education leaders exchanged ideas and strengthened Hong Kong’s role as a bridge between East and West.

Setting the tone for a purposeful week

The conference opened with remarks by APAIE President Professor Venky Shankararaman, CUHK Vice‑Chancellor and President Professor Dennis Lo Yuk-ming, and HKSAR Secretary for Education Dr Christine Choi Yuk‑lin.

Professor Shankararaman highlighted three enduring Asian principles – interdependence, harmony and universal responsibility – as values that offer strikingly modern answers to the sector’s most urgent questions and underscore the power of partnership for the global good.

Professor Lo expressed gratitude for CUHK’s opportunity to host the event again after 13 years, and emphasised this year’s theme captured a shared responsibility among universities worldwide to contribute diverse strengths and perspectives across borders and disciplines.

The ceremony also featured a spirited lion dance and eye‑dotting ceremony, hallmark of Hong Kong’s traditions. Award‑winning Hong Kong filmmaker Robin Lee shared insights from his documentary Four Trails, noting that Hong Kong’s cultural diversity is a prime attraction for international students. He encouraged the audience that everyone has their own four trails, each meaningful and unique.

Trust and resilience at the top

At the Presidents’ Dialogue, 25 university presidents and 45 senior leaders discussed intertwined risks reshaping higher education, from disruption driven by artificial intelligence to geopolitical tensions, climate change, demographic shifts and the spread of misinformation and disinformation. Under the theme “Building Resilience and Trust in an Era of Global Risks”, they explored strategies to future‑proof educational systems, accelerate innovation and cultivate resilient partnerships.

The leaders expressed optimism about the value of collaboration. Professor Lily Kong, President of Singapore Management University, highlighted the abundance of avenues that international engagement could unlock. She added that APAIE’s gathering of delegates from across the world signalled a strong appetite for collaboration and left her with optimism and hope.

Professor Helena Ramalhinho, Vice‑Rector for Internationalisation at Pompeu Fabra University in Spain, said that today’s problems could not be solved by a single city or country; for students and researchers alike, understanding global issues made international partnership indispensable.

International students’ voices

The Student Plenary, “Global Perspectives on Student Success in Hong Kong”, co‑chaired by CUHK’s Professor Irwin King and Hong Kong Baptist University’s Dr Albert Chau, gave eight students from seven countries a platform to reflect on how the city had shaped their academic journeys and personal growth.

Shiven Garg from India, a CUHK PhD student, shared how joining student clubs built his leadership skills and praised Hong Kong’s innovation ecosystem. “Hong Kong is the Silicon Valley of Asia. If you have an idea and want to bring it to reality, Hong Kong is the right place to be.”

Across the panel, students emphasised Hong Kong’s combination of academic rigour, innovation and unparallelled global connectivity, which empowers graduates to build networks that extend far beyond the region.

This event brought together all eight University Grants Committee funded universities to showcase Hong Kong’s worldclass academic excellence, innovation driven economy and cosmopolitan character. As a founding APAIE member and the 2026 lead host, CUHK reaffirmed its commitment to developing impactful global partnerships and nurturing future global citizens.

A photo feature on APAIE 2026 can be found here.

HKAPA’s Vision for Sustainable Development

Sustainable Development: From Legacy to New Horizons

Art is life, and life is art, as the saying goes.

In practical terms, that means the performing arts are not simply a form of self-expression. They also unite society through collective participation. They can even address issues of global importance such as climate change.

HKAPA has incorporated the United Nations Sustainable Development Goals (SDGs) into its management and curriculum. Academy Director Professor Anna CY Chan believes that responsible artists and cultural leaders should have the courage to blaze new trails rather than simply following the trodden path.

“We need to rethink how to promote the arts in a sustainable fashion,” she says. “Aside from raising public awareness, we need to adopt relevant measures in our artistic practices.”

The Academy aims to provoke a “green revolution” in the local arts industry while also staying committed to passing down its cultural legacy.

Through revitalisation, innovation, education, and community engagement, it strives to foster cultural preservation and artistic exchange, in the hope of creating a sustainable future where people and the environment coexist in harmony.

The ethos inspiring this drive stipulates that an artist’s mission should not be confined to aesthetic pursuits. At a time when climate change and sustainable development are issues of global concern, artists should also concern themselves with their own environmental responsibility as well as the sustainability of the performing arts industry.

The Academy is proactive in its promotion and implementation of sustainability concepts as a result. Building on Europe’s STAGES (Sustainable Theatre Alliance for a Green Environmental Shift) collaboration and the Theatre Green Book, Professor Chan incorporates tradition, innovation and sustainable development into education theory and practical training.

“We need to be aware of the interconnections between artistic creation and ecology, society and the economy,” Professor Chan maintains. “We should deploy technology to enhance cultural preservation, and we should strive to make a change in society and the environment.”

Through interdisciplinary collaboration, the Academy works with different sectors of society to build core ideas on cultural sharing and formulate an effective reform proposal for the cultivation of creative talent. “We need to ensure performing artists of the future and industry leaders are equipped with these social values, and a concern for global trends and topics,” she states. “This is our mission.”

The Imperative of Green Production

On how to turn ideas into action, Professor Chan indicates that the Academy will strive for breakthroughs in sustainable development at all stages of its efforts, from curriculum design, through production and operation, to venue construction. The aim is to redefine local contemporary theatre. Productions such as dance works will be scrutinised to assess their sustainability. “We must ponder how to convey the relevant messages onstage every step of the way, from design concept to backdrop, wardrobe and rehearsal,” Professor Chan indicates.

This new way of thinking will refresh old practices. For example, students will no longer make props just for a single production. They must be made with an eye on re-use.

Professor Chan admits this represents a significant challenge. “Cheap production materials are easily available online,” she concedes. “While they may simplify the props-and backdrop-making process, they exacerbate the problem of over-consumption. Change needs to start with the local industry. Only action can put a stop to high-speed consumption.” She adds that storage space is also a factor in implementing green theatre. “Space is required to keep production materials for the next production. It is another of our considerations.”

To gather views and suggestions, Professor Chan and stakeholders organised the first Hong Kong Culture and Sustainability Conference (CUSU) last November. CUSU is a platform for the pooling of ideas on how to implement sustainable development in Hong Kong, especially in the performing arts. The next CUSU conference, to be held at the Academy this coming October, will explore topics of culture and sustainability from an Asian point of view. The Academy will also share research and empirical data in sustainable performance productions and related areas accumulated over the past year.

Putting Green Living into Practice

Sustainable development may be zealously discussed in global climate conferences, but encouragingly, it is also practicable in almost every moment of daily living. Patrick Lee, Deputy Director (Administration) of the Academy, points out that creating a sustainable campus is a shared mission for the Academy as well as its teachers and students. As such, it requires the dutiful participation of everyone for its success.

“As a forest therapy guide and nature lover, when I see green, I don’t just see a forest, I see environmental protection,” Mr Lee says. “When I take a stroll on campus, I feel the care our members lavish on the environment, such as switching off lights and air conditioning after a lecture to save energy, bringing their own cups and eating utensils to reduce use of disposables, thereby honouring the commitment to zero waste. I see waste being sorted and used items being recycled to give resources a new life and maximise their value.” As these “little” habits build momentum, they contribute to a more sustainable earth.

Mr Lee believes that a sustainable campus is an organic ecosystem teeming with life where, in classrooms, teachers impart professional knowledge as well as concepts of environmental protection and sustainability; and in everyday life, students put theory into practice through green habits and a concern for nature.

“Looking ahead, infrastructure such as green buildings, a rainwater-harvesting system, and solar panels will also become teaching materials, enabling us to live in alignment with nature,” he indicates. 

Mr Lee believes that a sustainable campus is only possible with everyone’s input. He calls upon HKAPA community to sow the seeds of sustainability and water them daily as a good start toward a greener future. “May eco-consciousness extend from the campus to the community, and take us to ever-broadening horizons, becoming a beacon of warmth and light for the world,” he insists.

The Search for Statues

HKAPA aims to be a trailblazer for sustainable development in the arts, from talent cultivation and technological innovation to cultural preservation. In 2003, the Academy was handed the reins for the management and restoration of the historic Béthanie sanatorium, built by Missions Étrangères de Paris (the French Mission).

In the Academy’s hands, the site has transformed into a heritage campus for training talent in film and television. When restoration began, Béthanie had been abandoned for many years. Some of the chapel’s components had been lost, including the statues of the Twelve Apostles. Four were subsequently uncovered. Over the years, the Academy searched high and low, appealing to the public for information on the remaining eight. Last year, what is potentially the fifth statue was discovered.

According to records, Béthanie’s 12 statues of the apostles were crafted in France. The four statues on the Béthanie campus are now replicas. The original statues of St Matthew, St Thomas and St Paul are kept by St. Clare’s Girls’ School, and a fourth is in the possession of a private collector in the US.

Early last year, a local archaeology team contacted the Academy, indicating that a statue of St Johannes at St. Clare’s looked uncannily similar to the three previously discovered at the same location. Willie Kua, Deputy Head of Campus Development, liaised with the team and consulted Philip Soden, who was project director of the Béthanie restoration while serving as Associate Director (Operations) at HKAPA. After extensive field work and comparison studies, they concluded that the statues could very likely belong to the same set.

Mr Soden had asked what’s now called the School of Theatre and Entertainment Arts (TEA) to reproduce the four statues with silicone moulding. Any new replicas should be more advanced. With advanced replication technology now at the School of TEA’s disposal, Mr Kua notes, “3D scanning saves time as it does away with the need for repeated moulding and testing, and allows replicas to be made with environmentally friendly materials.”

Marriage of Technology and Tradition

The person in charge of the replication, Adam Bain, Senior Lecturer in Property Making at the School of TEA, points out that the St Johannes statue has three damaged fingers but is otherwise in fairly good condition. “There were no old photos to use as reference,” he notes. “We could only infer from similar statues how the fingers looked and how they were positioned. This was the biggest challenge.” 

However, other aspects of replication and restoration are simpler. In contrast to the moulding process in use 20 years ago, modern 3D scanning and printing incurs no risk of damage to the original. It is also easier to make adjustments and repairs such as reconstructing the fingers and fixing peeled paint. 

Adam recruited the assistance of The Hong Kong University of Science and Technology to identify the statue’s material using X-ray fluorescence. That analysis detected the presence of volcanic ash. As there are no volcanoes in France, it was assumed the material had come from southern Italy. 

“The result of the analysis was immensely helpful,” Adam says. “A replica needs to honour authenticity, a principle of relic preservation.”

Aside from accuracy, the team also has to ensure their methods are sustainable. “If we were to reproduce the statue using ceramic clay, procuring volcanic ash from southern Italy is not an ecofriendly option,” Adam continues. “Using volcanic ash from Chinese Mainland takes care of that aspect without affecting the results.” Adam says he has approached a local 3D printing service to acquire biodegradable materials that will contribute to a recyclable and degradable finished product that has minimal impact on the environment.

Technology has changed the way props are made. Computer-controlled procedures minimise carbon emissions and the production of solid waste. But Adam stresses that digital technology and Artificial Intelligence can never replace traditional craft. “We cannot jump from zero to 3D,” he says. “We need to understand traditional craft while also learning to use technology. Both approaches hold their own worth.”

The School of TEA is integrating know-how and experience gleaned from this project into its curriculum. Or Pui-yee, a fourth-year student in the Department of Theatre Design, sees this as a great learning opportunity. 

“Projects in the past leaned heavily towards stage production,” Ms Or says. “This one, being about relic preservation, opens up a path for the application of production technology to other areas.” She will replicate the statue using materials that are as close to the original as possible, and her work will be displayed at the graduation exhibition in June and July.

Legacy and Development

St. Clare’s Girls’ School, around 1.5 kilometres west of the Béthanie campus, was founded in 1927. Principal Mrs Cherry Chan points out that St. Clare’s started out as a convent of the school’s sponsoring body, the Missionary Sisters of Our Lady of the Angels from Canada. The nuns lived at the site for many years. Mrs Chan speculates that the French Mission, which sold the Béthanie site in 1974, passed the statues to the sisters to keep. The apostles have watched over generations of teachers and students at St. Clare’s as a result. Mrs Chan ascribes St. Clare’s connection with HKAPA, on the eve of the school’s centenary, to serendipity and “god’s will”. “HKAPA is an ideal manager for the Béthanie,” she says. “It has the resources, talent and professional knowledge to make replicas of the statues, which in turn offer students opportunities for research and hands-on learning. All this has been extremely meaningful.”

The Béthanie which opened as a sanatorium for missionaries in 1875, celebrated its 150th anniversary last year. This year, 2026, marks the 20th anniversary of the Academy’s official takeover of the site. To rediscover the likely statue of St Johannes at this time suggests the Academy is headed in the right direction, working on the sustainable and interdisciplinary preservation of relics, to safeguard history for future generations.St Johannes at this time suggests the Academy is headed in the right direction, working on the sustainable and interdisciplinary preservation of relics, to safeguard history for future generations.

HKAPA and UAS foster collaboration

To further strengthen academic ties and explore more opportunities in arts education, The Hong Kong Academy for Performing Arts (HKAPA) has signed a memorandum of understanding (MoU) with University of the Arts Singapore (UAS), Singapore’s first arts university formed by NAFA and LASALLE, on 12 May.

UAS top-leadership delegation led by Professor Kwok Kian Woon, UAS Vice-Chancellor, comprising Professor Steve Dixon, UAS Deputy Vice-Chancellor and President of LASALLE College of the Arts; Mrs Tan-Soh Wai Lan, UAS Deputy Vice-Chancellor and President of Nanyang Academy of Fine Arts, Mr Marcus Ngiow, Director, Planning and Development Division, and Ms Janet Ng, Principal Manager, Academic Planning Office.

HKAPA X IADMS Regional Meeting 2026

The School of Dance at The Hong Kong Academy for Performing Arts, in collaboration with the International Association for Dance Medicine & Science, proudly presents the IADMS Regional Meeting 2026.

This inspiring two-day programme will bring together dance educators, performers, postgraduate students, dance science specialists, and healthcare professionals from around the world. Through expert-led lectures and practice-based workshops, participants will explore holistic approaches to dance training, well-being, and performance. We are excited to announce our lineup of international speakers, featuring experts from Australia, the United Kingdom, Chinese Mainland, and Hong Kong, who will lead in‑depth talks and hands‑on workshops tailored specifically for dance teachers.

Programme Highlights:

1. Expert-led lectures and workshops

2. Stay updated with the latest research and gain research-driven teaching tools

3. Acquire practical strategies in conditioning, nutrition, and psychology to enhance overall health and performance

4. Learn sustainable and integrated approaches to dance education for long-term development

Theme Highlights:

Day 1 – Training for Longevity: Building resilience in the adolescent dancer’s body

Day 2 – The Analytic Teacher: Deconstructing technique for more effective instruction

Details:

Dates: 3 & 4 April 2026

Venue: HKAPA Dance Studio 1

Details & Tickets: https://www.hkapa.edu/dance/page/detail/71015

HKAPA FTV attended Art of Intelligence Forum

Dr Terry Lam, Dean of Film and Television of The Hong Kong Academy for Performing Arts, along with our faculty members, contributed to the Art of Intelligence Forum hosted by IBM earlier at the Hong Kong Palace Museum. They presented cineDESK, an innovative AI-integrated tool for the preproduction process of filmmaking.

With a diverse crowd eager to dive into the fusion of cutting-edge AI and traditional culture, the atmosphere was electric! Dr Lam shared with the audience his insights on “Creativity, Storytelling, and Human Imagination in the Age of AI”. Dr Michael Li, Principal Head (Digital Learning and Information Management) of the Academy, was also invited to attend this event. Let’s continue to blend the magic of the past with the innovations of the future in the world of art and intelligence! Join us on this brand new journey!

Learn more about the programmes on offer by the School: https://www.hkapa.edu/admissions/programmes

HKAPA Honorary Awards Ceremony

The Hong Kong Academy for Performing Arts (the Academy) has conferred Honorary Awards on five outstanding individuals in recognition of their significant achievements and contributions to the performing arts, the cultural industry, and the development of the Academy. The ceremony, officiated by the Academy Council Chairman Mr Charles Yang Chuen-liang SBS JP, was held at the Academy Lyric Theatre. Council Chairman Mr Charles Yang and the Academy Director Professor Anna CY Chan expressed their sincere gratitude for the Honorary Awardees’ exemplary services and unwavering support to the Academy and the community.  

 

Recipient of Doctorate of the Academy honoris causa:

Mr William Au Weng-hei SBS JP

 

Recipients of Honorary Fellowship:

Mr Chen Qing

Mr Leo Cheung Kwok-wing

Mrs Yvonne Law Shing Mo-han BBS JP

Ms Wu Han

HKAPA School of Chinese Opera in Italy

Exciting news from The Hong Kong Academy for Performing Arts!

Our 20-member delegation, led by the Dean of Chinese Opera Professor Martin Lau, proudly supported by HKETO Brussels, has arrived Italy.

After a warm welcome in Milan, they wowed the audience at the Conservatory of Music “G. Nicolini” in Piacenza with captivating Cantonese opera excerpts and stunning Chinese music solos! The response was incredible and attracted local media coverage:

  1. https://cinainitalia.com/2025/11/06/opera-cantonese-unarte-millenaria-tutta-da-scoprire/
  2. https://www.ilrestodelcarlino.it/pesaro/cronaca/lopera-tradizionale-cinese-in-scena-4d478c46

We can’t wait to bring more of the unique charm of Cantonese opera to European stages!

HKAPA School of Music Presented Rachmaninoff Piano Festival

To commemorate Russian composer Sergei Rachmaninoff’s 150th anniversary of his birth, The Hong Kong Academy for Performing Arts’ School of Music successfully presented the Piano Festival covering nearly the renowned composer’s complete works for solo and two pianos, the first time ever in Hong Kong. Professor Gabriel Kwok, Head of Keyboard Studies, would like to thank all the teachers, alumni and students for taking part in the Festival.
These six concerts of the Festival are broadcast on RTHK Radio 4 from Apr 24 to 29.
Programme: RTHK Radio 4 – “Live on 4”
24 – 29.4.2023 | 8pm
https://www.rthk.hk/radio/radio4/programme/Liveon4

EdUHK Research Reveals Kindergarten Teachers’ Perceptions of Whole-child Development

This study by Dr Chrysa Keung Pui-chi, Assistant Professor at the Department of Education Policy and Leadership, The Education University of Hong Kong, examined the relationships between leadership practices, professional learning communities, teachers’ efficacy beliefs and perceptions of whole-child development in the context of kindergarten education.

Educational reforms have recently focused on improving collaborative cultures and teachers’ instructional quality by building professional learning communities (PLCs) in kindergartens. According to the literature, teachers in PLCs conduct ongoing reflection, collaboration and collective learning to form a shared vision of children’s learning, and there may be some relationships between leadership practices, PLCs, teacher efficacy, and teacher perceptions of whole-child development. 

The importance of the principal’s leadership practices in developing a PLC has been extensively supported in studies of school leadership. A PLC creates opportunities and conditions for implementing new professional practices.

Although PLCs are increasingly viewed as an important context for continuous improvement in teaching effectiveness and school improvement, very few studies have investigated the role of PLCs in improving kindergarten teachers’ practices and children’s learning.

A questionnaire was given to 2,120 teachers from 153 Hong Kong kindergartens. The questionnaire comprised four scales: (1) The 21-item Leadership Practice Scale, (2) The 20-item Professional Learning Community Scale, (3) The 12-item Teacher Efficacy Scale, (4) The 15-item Whole-Child Development Scale.

This research project fills the gaps in the literature by providing an investigation into the relationships between leadership practices, PLCs, teachers’ efficacy and perceptions of whole-child development, focusing particularly on the mediating role of PLCs and addressing (1) the effects of leadership practices on PLC components in kindergartens, (2) how significantly leadership practices are associated with kindergarten teachers’ efficacy beliefs and their perceptions of whole-child development, and (3) whether PLC components significantly mediate the relationships between leadership practices and kindergarten teachers’ efficacy beliefs and their perceptions of whole-child development.

The study found that principals’ leadership practices had a significant effect on all five PLCs: collaborative activity, collective focus on student learning, deprivatised practice, reflective dialogue, and shared sense of purpose. Kindergarten principals adopting effective leadership strategies had a great impact on developing a culture of shared purpose and a sense of collective responsibility for children’s learning. Leadership practices were also positively related to teachers’ perceptions of whole-child development directly and indirectly through the mediation of three professional learning community components: shared sense of purpose, collaborative activities, and collective focus on student learning.

The mediation analysis revealed that three PLC components were positively associated with teachers’ perceptions of whole-child development via their efficacy beliefs: (1) a collective focus on children’s learning, (2) deprivatised practice and (3) reflective dialogue. 

The structural equation modelling analysis also showed that PLCs positively mediated the relationships of principal leadership to teacher efficacy and teachers’ perceptions of whole-child development. But except for a collective focus on child learning, PLC components in general had relatively weak relationships on teachers’ efficacy and perceptions of whole-child development.

The findings support the mediating role of PLCs in developing kindergarten teachers’ collaboration for improving their efficacy beliefs and perceptions of the whole-child development of children. Kindergarten principals play a key role in cultivating a supportive culture and facilitating teacher learning.

The study was conducted together with Professors Yin Hongbiao and Chai Ching-sing, Mr Clement Ng Ka-kit and Ms Winnie Tam Wing-yi at The Chinese University of Hong Kong. To learn more, please visit here

HKBU-led research discovers new therapeutic target for irritable bowel syndrome

A research study led by scientists from the School of Chinese Medicine (SCM) at Hong Kong Baptist University (HKBU) has shown for the first time that the human gut bacterium Ruminococcus gnavus is a major trigger factor of diarrhoea-predominant irritable bowel syndrome (IBS-D). Based on this discovery, a new therapeutic target for the disease’s treatment was identified. The study also found that low-protein food items such as fresh fruits, vegetables and bread may help reduce the gut motility in IBS-D.

The research findings have been published in the internationally renowned scientific journal Cell Host & Microbe. 

Curative treatment for IBS-D needed 

Irritable bowel syndrome (IBS) is a common functional bowel disorder characterised by stool irregularities, abdominal discomfort and bloating. It has been estimated that about 7% of adults in Hong Kong are affected by IBS. IBS-D is the most common type of IBS and there is no known cure for the disease. Most clinical treatments for IBS-D focus on relieving symptoms. 

Previous research has demonstrated that the increased production of serotonin, a key neurotransmitter involved in the regulation of gut motility, contributes to the gastrointestinal symptoms displayed in IBS-D. It has also been shown that gut microbiota play a role in regulating the levels of serotonin. However, the bacterial species concerned and the molecular mechanism by which the gut microbiota modulate serotonin production remain unclear. 

Phenethylamine and tryptamine produced by Ruminococcus gnavus trigger IBS-D  

To explore curative treatment options for IBS-D, a research team co-led by Professor Bian Zhaoxiang, Director of the Clinical Division and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies;  Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division; and Dr Zhai Lixiang, Post-Doctoral Research Fellow of SCM at HKBU, screened
thousands of food components and their breakdown products in the fecal samples of 290 patients with IBS-D. They found that phenethylamine and tryptamine, two
aromatic trace amines produced by the microbial digestion of dietary proteins, are highly enriched in IBS-D faeces, and they are associated with the severity of diarrheal symptoms in patients with IBS-D. 

Probing further, the researchers found that mice which had been fed with either phenethylamine or tryptamine experienced increased stool frequencies and colonic secretions, which are major symptoms of IBS-D. 

On the other hand, the team found that the gut bacterium Ruminococcus gnavus, which is enriched in IBS-D faecal samples, is a primary producer of phenethylamine and tryptamine. Furthermore, mice with this bacterium transplanted into their guts go on to develop IBS-D diarrheal symptoms. These results suggest that phenethylamine and tryptamine produced by Ruminococcus
gnavus
trigger IBS-D in mammals without the involvement of other risk factors of IBS-D. 

Phenethylamine and tryptamine stimulate serotonin production 

The research team further conducted a series of experiments to understand the mechanism by which phenethylamine and tryptamine lead to IBS-D. The results showed that phenethylamine and tryptamine directly stimulate the production of serotonin from the enterochromaffin cells in the gut through the activation of a trace amine-associated receptor (TAAR1), thereby stimulating gut motility and secretion disorders in IBS-D.   

The team then explored the therapeutic potential of targeting the phenethylamine/tryptamine/TAAR1 pathway for the treatment of IBS-D. It was discovered that inhibition of TAAR1 activation through the use of a specific inhibitor effectively alleviated the diarrheal symptoms in mice which had been transplanted with IBS-D faecal samples. 

Prospects for new therapeutic options

“With a full outline of the mechanism of how gut microbiota associate with gut motility disorders, our research results suggest that the phenethylamine/tryptamine-mediated TAAR1 pathway is a new therapeutic target for IBS-D,” said Dr Zhai Lixiang. 

“IBS-D patients experience frequent episodes of diarrhea with accompanying abdominal pain, which reduce the quality of life. The research discoveries offer promising potential for the development of therapies for IBS-D based on the inhibition of the pathway,” said Professor Bian Zhaoxiang.

The research team also found that a diet low in phenylalanine, an amino acid and a dietary precursor of phenethylamine,
suppresses gut motility in mice by reducing the microbial production of phenethylamine and tryptamine
. Low-protein food items such as fresh fruits, vegetables and bread have relatively low levels of phenylalanine.
 

“Developing strategies to reduce the microbial transformation of dietary amino acids into phenethylamine and tryptamine, such as dietary intervention with reduced consumption of high-protein food items which usually have high phenylalanine levels, may represent a feasible approach for the management of IBS-D,” said Dr Xavier Wong.