Cosmetic Product from Rosehip Flowers

S.D. Asfendiyarov Kazakh National Medical University (KazNMU) is the leading Kazakhstani university in the field of medical and pharmaceutical education, and its Faculty of Pharmacy, transformed in 2017 into the School of Pharmacy, has become part of the modern pharmaceutical industry, the first in the country forge of pharmaceutical personnel with a rich history and traditions. The School of Pharmacy has developed a number of original formulations of perfume and cosmetic products created by introducing the achievements of modern pharmaceutical science and new production technologies from plants growing in Kazakhstan. The new domestic cosmetic product Fitoleum Cream from rosehip flowers is one of the examples of such effective cooperation of pharmaceutical

science, production and new technologies. Development of plant pharmaceutical substances and on their basis innovative cosmetic products from Kazakhstani plants - one of the leading areas of pharmaceutical-technological research in the School of Pharmacy KazNMU.

Plants growing in the harsh natural conditions of the mountains of Almaty region are rich in phytochemical compounds with a wide range of biological activity, including antioxidant, anti-inflammatory and UV-protective properties. Extracts of such plants are a potentially interesting source of active ingredients for cosmetics that protect the skin from the harmful effects of environmental factors, including air pollution and UV radiation.

The School of Pharmacy of KazNMU and the pharmaceutical company “FITOLEUM” have been cooperating for more than 30 years. The University provides the company with professional staff. And the company organizes scientific and industrial practice of students at its base, production, laboratories. Master's and PhD-doctoral students have the opportunity to conduct their scientific research at the production facilities.

As a result of cooperation, pharmaceutical developments of new drug substances, original technologies, creation of dosage forms based on natural plant and mineral raw materials are created.

In the School of Pharmacy of KazNMU named after S.D.Asfendiyarov an original formulation and optimal technology of cosmetic cream with rosehip was developed. The patent of the Republic of Kazakhstan on “Cream possessing antioxidant, brightening, anticollagenase, anti-elastase, antityrosinase, antimelanoma actions” was received.

An integrated concept of full cycle production of cosmetic products has been developed in accordance with the requirements of international standards of good practices (GACP, GMP, GSP), as well as the Technical Regulations of the Customs Union, State Standard and Sanitary Rules of the Republic of Kazakhstan.

To standardize the quality of cosmetic cream with rosehip developed and approved normative document for perfumes and cosmetic products ̶̶ standard of the organization ST LLP 040840006381-01-2022. Consumer quality and safety of cosmetic cream is provided by checking its organoleptic and physico-chemical indicators, determination of impurities of elements, pesticides and microbiological purity.

Long-term stability tests of the cream showed that for the study period (12 months) significant changes in quality indicators are absent, and the results are within the regulated norms. Based on the data obtained, the recommended storage conditions of the cream cosmetic (temperature not more than 25 ° C and relative humidity not more than 65%). The shelf life (shelf life) of the product until the completion of long-term stability tests was 1 year.

Fitoleum Rosehip Flower Cream is a cosmetic product for the skin of the face, neck and décolleté areas. It contains a high concentration of natural ingredients, which deeply moisturizes and nourishes the skin, helps to smooth wrinkles and even out the tone. The cream restores the hydrolipidic mantle, reduces and prevents inflammation, reduces capillary fragility, lightens age spots.

The delicate texture of the product makes the skin soft, silky and well-groomed. Rosehip flowers reduce skin irritation, slow down the destruction of collagen and elastin in the skin, neutralizes free radicals, which helps to prolong

skin youth and protect against photo-aging. The cream's active ingredients are: rosehip flowers, shea butter (or karite oil), panthenol, hyaluronic acid and aloe vera - a plant known for its medicinal and cosmetic properties for thousands of years.

Rosehip flowers are collected by hand in ecologically clean areas of Zailiyskiy Alatau during the period of maximum accumulation of pharmacologically active substances.

The uniqueness of the product is that the original formula contains an extract of wild mountain rosehip flowers, which has a pronounced antioxidant, regenerating, nourishing, moisturizing and rejuvenating effect. The technology and

composition of the cream are patented in the Ministry of Justice of the Republic of Kazakhstan.

Pharmaceutical quality system of production of FitOleum LLP is four times confirmed by GMP certificate, which means that the company guarantees the release of high-quality, safe and effective medicines based on natural raw materials collected in ecologically clean areas of Zailiyskiy Alatau and on its own plantations.