Scientists propose new optical switch for high-speed computers

Scientists of Tomsk Polytechnic University jointly with their colleagues from Great Britain have proposed a physical concept of a new optical switch that forces to change light wave guidance.  The switch is a small glass particle of an unusual form.

Its size is only about 1 µ. The research findings are published in the Annalen der Physik academic journal (IF: 2,276; Q1). According to the authors, such a simple switch can be used in high-speed optical computers in the long run.

Information is transferred by electrons in all currently existent calculating machines, including computers. Scientists believe if electrons inside the computers are replaced with photons, i.e. light quantum, then the data can be transferred literally at lightspeed. Researchers and companies of different countries are working on creating an efficient optical quantum computer.

Prototypes of such computers have already been presented in the USA and China, however, these computers are capable to solve a very limited range of tasks. To widely apply optical computers, researchers still have to overcome a lot of obstacles.

“In such machines, it is essential to switch a signal at very high speed, i.e. to change the light guidance. Therefore, efficient switches are required. Researchers solve this task in different ways. Some researchers propose mechanical switches, however, these switches do not provide the required switching speed. While the others use specific crystals based on the nonlinear effects, which require developing new special materials and methods of controlling them,” Oleg Minin, Professor of the Division for Electronic Engineering of the TPU School of Non-Destructive Testing, a supervisor of the project, says.

“We proposed another principle in our article: particles of special forms from dielectric material can change the light guidance efficiently. In this case, we considered glass. Moreover, the proposed method does not require the application of metals.” Oleg Minin continues.

The proposed switch is a small cube-shaped glass particle with a prism attached to it. Its operation is based on the effect of the photonic hook that was previously discovered by the research authors.

“It is a matter of a particle shape. Previously, we discovered that the light percolating a dielectric particle of this shape twists as a hook at the output. Due to its physical properties, the photonic hook possesses a very wide range of potential applications. In this case, the calculations show if we change the light wavelength percolating the particle, then it is possible to change hook guidance.  That is the core of switching the signal, in changing the guidance,” Oleg Minin notes.

The researchers are currently preparing to conduct a series of experiments, which will prove the results of the simulation and calculations. The experiments will be conducted at Bangor University (Great Britain).

The research was conducted with the partial support of the Russian Foundation for Basic Research and the TPU Competitiveness Enhancement Program.

TPU scientists research danger of fire break-out around Lake Baikal

Scientists of Tomsk Polytechnic University have developed a methodology for forecasting forest fires on the example of the surroundings of Lake Baikal. The methodology is based on an atmospheric soil measuring complex (ASMC).

The research was supported by the grant of the Russian Foundation for Basic Research No. 17-29-05093. The research findings are published in the International Journal on Engineering Applications.

Since 2018, the project has been implemented under the supervision of Nikolay Baranovsky, Associate Professor of the TPU Butakov Research Center. The project aimed at developing techniques for monitoring of inflammability of forests in the conditions of human impact on the area of Lake Baikal basin.

“Lake Baikal is the largest natural reservoir of fresh water and characterized by unique flora and fauna. The lake life cycle is mainly dependent on the processes occurring in the coastal area: natural and human, including forest fires. It can influence the lake drainage and change the regime of its functioning. Therefore, assessment of forest fire break-out from human impact is crucial for understanding the processes influencing the activity of Lake Baikal,” Nikolay Baranovsky notes.

Scientists of Tomsk Polytechnic University, Gorno-Altaisk State University, Institute of Physical Materials Science of the Siberian Branch of the Russian Academy of Sciences, Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences and Paris Diderot University (France) took part in the research work.

Using the ASMC, the researchers conducted monitoring of meteorological conditions and soil characteristics, i.e. they recorded the air humidity and temperature, speed and wind direction, the amount of rain precipitation and soil temperature.

The measurements were carried out in the surrounding of Khurumsha (a rural locality in the Republic of Buryatia). The data of some specific days of summer 2019 were used to conduct the research. Based on these data, the scientists offered to use a number of mathematical formulas to assess fire danger.

“The analysis of data has shown that there may be a situation in the forest area when a ground fire turns into a crown fire. Some special conditions are required for that.

First, the canopy of a forest stand must possess the sufficiently small value of the lower limit of the branch position. Second, the speed of the ground fire must be quite fast. It mainly depends on the wind speed inside the forest area.

In this case, the wind is a driver of turning the ground fire into the crown fire. Presumably, there will be various values of critical wind speed for miscellaneous types of forest areas. This problem requires additional study,” Nikolay Baranovky explains.

Despite the fact that the project possesses a fundamental character, the scientists claim the research findings can form the basis of applied developments. In particular, the scientists from the Institute of Physical Materials Science of the Siberian Branch of the Russian Academy of Sciences under the supervision of Alexander Bazarov are planning to create a network of ASMCs in the Republic of Buryatia to monitor, assess and forecast forest fire danger.

The research work within the project of the Russian Foundation for Basic Research No. 20-31-51001 on analysis of the influence of human impact from main railway lines on forest fire danger is ongoing as well.

The scientists tell about the results of these projects in the series of podcasts on Yandex Music, a music streaming service.

TPU scientists offer affordable technology to obtain PTFE Membranes for medicine and next generation of energy industry

Scientists of Tomsk Polytechnic University were able to obtain polytetrafluoroethylene (PTFE) membranes using electrospinning. PTFE is known to be the most stable existent polymer.

According to the scientists, it is a simple, affordable and easily scalable method, which will allow obtaining chemically stable membranes in industrial-scale production. The membranes can be used in petrochemical, aerospace, nuclear industries, carbon-free energy and medicine.

The latest results of the research of physical and chemical properties and biocompatibility of the obtained membranes are published in the Journal of Fluorine Chemistry (IF: 2,332; Q1). The obtained membranes were tested using cells and laboratory animals. The research confirmed that the membranes are not rejected by the cells and are not destroyed in the biological matrix. The interdisciplinary team consisting of physicists and chemicals is currently conducting the research at TPU.

“The material and methods of work with it were noteworthy for us. PTFE is a polymer containing fluorine. Fluorine and similar compounds are called fluoropolymers. They are noteworthy for scientists and experts working at industrial enterprises due to their inert. Fluoropolymers can be used in corrosive media or where material stability is crucial. These either can be hydrogen fuel cells operating in the conditions of corrosive media or a medical implant inside a human body. It means that obtaining membranes is very perspective, however, there is no large capacity technology in the world yet. It is either expensive or labour-intensive, even if the raw material is affordable,” Evgeny Bolbasov, Research Fellow of the TPU Butakov Research Center, says.

The TPU scientists used electrospinning. It is drawing charged threads of polymer solutions under the effect of an electric field. The result is a knitted material of polymer threads.

“The main advantage of the method is that the small laboratory installation is not different from an industrial one by its core and processes. Everything that can be done in the laboratory is easily reproducible at the enterprise. Previously, it was believed that obtaining a PTFE membrane using electrospinning is simply impossible. PTFE is not pulled into threads. To solve this problem, we added polyvinyl alcohol (PVA), a crosslinking agent in the synthesis chain,” the scientist says.

The process of obtaining the membrane described in the article carries two stages. First, very fine powder is mixed with PVA. A solution loading in the electrospinning installation is obtained. The thinnest threads are pulled inside of the electrospinning installation and the white porous bed is spun from these pulled threads. It is the membrane. At stage two, the membrane is fired in an oven at about 400°С. The added PVA completely evaporates in the oven and the membrane is getting dark a bit. The entire process takes no longer than three hours.

The researchers note that all raw materials used for the synthesis are commercially affordable and are produced in Russia.

These membranes possess a wide range of potential applications. Only a scalable technology is required. Industrial methods of obtaining membranes from fluoropolymers are searched in Europe, the USA, China. Meanwhile, the Russian scientists possess an opportunity to offer a commercially interesting solution. From our point of view, electrospinning is such a solution.

This method is a dozen folds cheaper than its alternatives, it allows easily controlling the pore structure of the membranes. Moreover, this method is reproducible and scalable, which is very interesting for potential industrial partners,” Vyacheslav Buznik, an academician of the Russian Academy of Sciences, one of the article authors, says.

“Currently, the main task of the TPU researchers is to show the method opportunities for solving specific applied problems. The task is complicated, complex. It can be solved only by interdisciplinary teams consisting of materials specialists, chemists, physicists. It is crucially important for us that there are all the required experts and competencies at TPU. It will help us to actively develop this field,” Marina Trusova, Director of the TPU Research School of Chemistry and Applied Biomedical Sciences, notes.

TPU scientists synthetize unique molecule of Verdazyl-Nitronyl Nitroxide Triradical

Scientists of Tomsk Polytechnic University jointly with their colleagues have synthetized a unique molecule of verdazyl-nitronyl nitroxide triradical. Only several research teams in the world were able to obtain molecules with similar properties. The molecule is stable. It is able to withstand high temperatures and obtains promising magnetic properties.

It is a continuation of scientists’ work on the search for promising organic magnetic materials. The research findings are published in the Journal of the American Chemical Society (IF: 14.612, Q1).

Magnetoresistive random-access memory (MRAM) is one of the most promising technologies for storage devices. Nowadays, the MRAM development is limited due to the fact it is impossible to create a smaller memory cell because of spontaneous magnetization reversal. Single-molecular magnets based on organic compounds are free from this disadvantage:  few molecules are already capable to operate as a memory storage unit.

“At a certain temperature, a magnetic phase transition occurs, the consistent orientation of the magnetic vectors of molecules is observed, as a result, the matter becomes a united magnet. Thus, 20-40 molecules are quite enough to form a micromagnet.

Our task in the research laid in creation such a molecule that could be capable to give its magnetic properties at high temperatures, would be crystalline and would possess a small distance between radical centers,” Pavel Petunin, Associate Professor of the TPU Research School of Chemistry and Applied Biomedical Sciences, an article author, explains.

When creating the molecule, the scientists worked with three radical centers in one molecule combined them in one conjugated structure. To synthesize the molecule, the scientists used a palladium-catalyzed reaction of a verdazyl radical with a gold complex of a nitronyl-nitroxyl radical.

The course of the reaction was complicated due to the presence of unpaired electrons in starting compounds, as well as the combination of three radical centers in one molecule, which affects its stability. According to the scientists, there are no other ways to synthesize the molecule.

The research teams from TPU, the Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences, the Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, the Voevodsky Institute of Chemical Kinetics and Combustion of the Siberian Branch of the Russian Academy of Sciences and International Tomography Center of the Siberian Branch of the Russian Academy of Sciences took part in the molecule synthesis. The research work was conducted within the project of the Russian Science Foundation No. 20-73-00236 “Stable Organic Radicals as Promising Building Blocks for New Materials”.

“The published research not only makes a significant contribution to the development of stable verdazyl radicals but it is also a meaningful publication for TPU. Research teams of the TPU Research School of Chemistry and Applied Biomedical Sciences perfectly complete the mission, which was determined at the moment of the School creation. The Journal of the American Chemical Society is the most peer-reviewed chemical journal. Research teams around the globe are intending to publish their articles in this journal. It should be noted that it is a cycle of the research works of the research team. The authors have recently published their research work in the equally top-rated Angewandte Chemie academic journal (IF: 12.959, Q1),” Marina Trusova, Director of the TPU Research School of Chemistry and Applied Biomedical Sciences, says.

At the moment, the researchers have approached complicated molecules and are planning to synthetize almost impossible molecules: heterospin and high-spin dendrimers.

Scientists apply an innovative welding method in bridge construction

Researchers from Peter the Great St. Petersburg Polytechnic University (SPbPU) were the first in Russia to develop a friction stir welding technology of a new aluminum alloy for a lightweight pedestrian bridge. The engineers intend to implement an innovative approach at the university: they plan to weld the elements, and then connect them into a bridge at the construction site.

The aluminum pedestrian bridge will be located in the town Bor in the Nizhny Novgorod region (Russian Federation). This will be the tenth aluminum pedestrian bridge in Russia, but the new alloy and friction stir welding technology will be used in bridge construction for the first time. Scientists work in collaboration with the SGR aluminum structures plant in St. Petersburg. The project is supervised by the Aluminum Association of Russia.

In the laboratory of Lightweight Materials and Structures of SPbPU, the engineers will connect about 20 parts of 8 meters long and 16 mm thick made of an aluminum-magnesium alloy. According to scientists, this new alloy has just recently become available for widespread use.

“The bridge is large and has many types of connections,” explained Anton Naumov, associate professor of the Institute of mechanical engineering, materials and transport of SPbPU, adding that the scientific group is developing a technology of friction stir welding for butt joints of aluminum plates on both sides of the plates.

The researcher added that this type of joint will surpass the arc welding in quality.

The scientist also noted it’s more economically profitable to weld a thick aluminum sheets in this way since the arc welding is using a number of additional manipulations (for example, arc welding is carried out in several passes to fill the entire thickness of the seam with the filler wire).

In addition, friction stir welding is a green technology because there is no evaporation of material or luminescence. “The new high-strength aluminum alloys successfully compete with the structural steels in terms of mechanical properties, also, in terms of weight, the aluminum structure will be much lighter than the steel ones. Therefore, the implementation of the aluminum bridges is increasing worldwide,” says Anton Naumov.

The experts of the Laboratory of the Lightweight Materials and Structures SPbPU are developing a welding technology. Then the quality control of the welded joints will be carried out to ensure the safety of the structure.

“Innovative technology of friction stir welding is already used in the bridge construction: the plant “Sespel” uses it for the components of orthotropic plates from the well-known aluminum alloy 6082 T6. But the new bridge will be the first bridge in Russia manufactured using a friction stir welding technology for the new Al-Mg alloy,” mentioned Evgeny Vasiliev, the Head of the transport infrastructure of the Aluminum Association of Russia. According to him, this is a serious task and a real technological breakthrough.

The researchers plan to complete their part of the project by the end of September. The 121-meter length bridge is planned to be commissioned by 2022.

Scientists study particles in a magnetic fluid for use in healthcare

A team of researchers from Saint Petersburg Electrotechnical University “LETI,” Peter the Great Saint Petersburg Polytechnic University, and the Technical University of Madrid tested and improved a classic approach to the research of magnetic fluids – liquid substances that get polarized in the presence of a magnetic field. The results of the work were published in the “Applied Sciences” journal.

Magnetic fluids consist of two immiscible phases: magnetic material particles (from several nanometers to several micrometers in size) and a polar or nonpolar dispersion medium. Such fluids are considered colloid systems: they don’t hinder light transmission but disperse the rays of light. Moreover, they don’t settle out because of the chaotic thermal motion of molecules. Magnetic fluids have several important properties: they are resistant to transitioning into other physical conditions, can preserve magnetization after it reaches its top level, and change their viscosity when magnetized.

Fluids like this are used in the mining industry, machine building, electronics, and medicine. For example, they can serve as lubricants and coolant materials or transfer power and energy from one mechanism to another. Different areas of application require magnetic fluids with different particle concentrations. To achieve a necessary concentration, the fluid is diluted several times. However, because of it, particles can stick together, and important properties of the fluid may be lost.

To properly prepare a diluted magnetic fluid, one needs to analyze the particle size distribution. In this process, one could use optic methods such as dynamic light scattering (DLS) — an approach based on the analysis of the time behavior of light scattering intensity on a sample. Still, the standard DLS technique does not provide data on the shape of the particles. Moreover, when the particles in diluted magnetic fluids stick together, it is impossible to study them individually.

A team of researchers including Kamil Gareev, a researcher at the Department of Micro and Nanoelectronics of ETU “LETI,” decided to use the original DLS method to study the size distribution of both individual magnetic particles and their aggregates in magnetic fluids. They synthesized magnetite–silica magnetic fluid from a water solution of iron (III) chloride and iron (II) sulfate following a method patented by LETI and studied its optical, structural, and magnetic properties.

The particle composition of the magnetic fluid was studied using microscopy, while its phase composition was analyzed based on the reflection of X-rays and electrons from the particles. To study the magnetic properties of the fluid, the team chose the method of vibrating sample magnetometry.

To analyze the shape of the particles, the team improved the DLS technique. This way, they managed to study the quantitative characteristics of magnetic material particle motion in a fluid medium for the first time. Namely, they focused on the translational and rotational diffusion coefficients of individual magnetic particles and their aggregates. The values of these parameters are determined by the rotational influences of the chaotic thermal motion of molecules and are indicative of particle sizes.

Using this data, the team calculated the geometrical parameters of nanoparticles and their aggregates and found out that the former had almost spherical shapes while the latter were more elliptical. The spherical shape of 10–20 nm large magnetic nanoparticles determined their superparamagnetic properties, i.e. the absence of the magnetic moment without an external magnetic field.

These characteristics are especially important for medicine: superparamagnetism prevents the particles from sticking to each other in the bloodstream and reduces the risk of thrombosis. Moreover, because of this property nanoparticles can be used as a magnetically controlled carrier for targeted drug delivery and as a contrasting agent in MRI.

“Using the improved DLS technique, we have studied the structural properties of magnetite–silica nanoparticles and made one more step towards introducing them into medical practice, namely MRI. Moreover, our method could be used to study nanoparticles not only in magnetic fluids but also in biological solutions,” explains Kamil Gareev, a researcher at the Department of Micro and Nanoelectronics of ETU “LETI.”

According to the team, when diluted 200 or more times, a magnetic fluid loses its stability, and its particles form aggregates around 140 nm in diameter. In the future, the researchers plan to find out at what level of dilution magnetic fluids lose their resistance to sedimentation.

Mining University graduate on how to prevent industrial disasters

Some say that all industrial disasters are either attributable to the human factor – whether caused by accident, negligence or incompetence – or natural phenomena. Sometimes both happen at a time. Olga Baranova, Saint Petersburg Mining University’s graduate, Chief Engineer for Occupational Safety at Karelsky Okatysh, explains, “Despite all the developments in process safety management and new techniques for monitoring and preventing workplace hazards, most natural phenomena causing incidents are still unpredictable.

“Scientists’ role is to learn how to anticipate these hazards and react in time and accordingly. Besides, a well-managed mechanism of action should be elaborated in case an emergency takes place.”

The company Olga works for introduced a monitoring centre. Its specialists can track the technical status of a facility right on their screens. Cameras and digital sensors, both stationary and mounted onto heavy-duty equipment, transmit data. 

This system helps monitor hazards and other emergencies. It is also suitable for administering weekly large-scale blasts done to open a deposit. Monitoring centres are a brilliant example of how a preventive measure, although a rather expensive and, for now, non-compulsory one, significantly reduces the risks of workers’ deaths. 

“In an ideal situation, specialists in occupational safety and health should exercise an advisory function – assist in mapping out and complying with regulations, striving to lower risk probability at an organisation. But in reality, we are, in a way, supervisors. In addition to proactive measures, we also impose compliance enforcement measures. The company has adopted a set of rules aimed at reducing injury rates. For example, all of our entry control points are equipped with alcohol-screening devices, which cannot be bypassed. Railway crossings intersecting mining and processing sites are mounted with a hardware-software complex. It utilises artificial intelligence and computer vision technologies to search for vehicles in the surveillance zone. It is a common situation and is a human error, but it may have tragic consequences. Therefore such violations should be monitored.”    

The future lies in digitalisation and automation technologies. They will make it less needed to be exposed to hazardous working environments, thereby enhancing industrial safety. Remote-controlled machinery and equipment are some of the newest solutions: autonomous dump trucks, drilling rigs, positioning and movement monitoring systems tailored at mine workers, and laser scanners. Of course, new technologies will not replace humans. Still, they will free us up for working at a new qualification level.

“We are currently testing exoskeletons that we plan to purchase for the company. This innovative device is designed to increase muscle strength and yet relieve muscle tension. Exoskeletons help relieve the stress of a person remaining mostly stationary while at work. It can be, for example, a mechanic who repairs machinery and is forced to keep their hands elevated over time.”

Karelsky Okatysh’s Department of Occupational Health and Safety employs over 20 specialists, with some of them working in the head office and others at production facilities. A majority of them are Mining University’s graduates who studied industrial and labour safety, geomechanics, rock destruction, and mining thermal physics.

TPU to become pilot participant in federal program for student tourism

Tomsk Polytechnic University is the only Tomsk university among 15 pilot participants of the federal program for student tourism development, which will start in Russia in July. This summer, students from other cities who want to visit Tomsk will be able to stay at TPU health and recreation center (13 Usova Str.).

In April 2021, Russian President Vladimir Putin in his Address to the Federal Assembly emphasized the importance of developing student tourism in the country. The Ministry of Education and Science of the Russian Federation supported this initiative and began to develop a special program.

The ministry has identified a list of pilot participants in the program for 2021. Now a digital platform is being created, where students will be able to choose a university, a place to stay and book it. Students with Russian citizenship only will participate in the pilot phase of the program.

“Being a part of student community is a wonderful time of discoveries. When else if not now to travel, meet new cities and get to know your country. Tomsk is definitely the city worth visiting. TPU will be ready to host students from other cities and accommodate them in our comfortable health and recreation center. It is located in the center of the city, surrounded by many affordable food courts. In summer, about 90 beds will be available.

The rooms are designed to accommodate two, three and four people. We will host student tourists from July 15 to August 25,” Andrey Yakovlev, TPU Acting Rector, says.

Under this program, students from other cities will be able to come to Tomsk both in organized groups and individually. The cost of accommodation will amount to 100 rubles per day. According to the terms of the program, it will be possible to stay at the TPU campus for 3 to 14 days.

In addition, TPU will develop proposals for a cultural program for incoming students. This information as well as other details, for instance, how to get to TPU campus, nearest food courts, all essential contacts – will be placed on the digital platform.

Scientists find simple method to enhance responsivity of terahertz radiation detectors by 3.5 folds

Scientists of Tomsk Polytechnic University jointly with colleagues from Spanish universities have offered a simple method how to enhance the responsivity of terahertz radiation detectors by 3.5 folds using a small Teflon cube.  The 1 mm cube must be put on the surface of the detector without changing the inner design of the detector.

Such detectors are applied, for instance, in a full-body scanner, spectrometer, in medical devices for diagnosing skin cancer, burn injuries, pathological changes in the blood.  The research findings are published in the Optics Letter academic journal (IF: 3,714; Q1).

Terahertz range lies between microwave and infrared ranges in the electromagnetic spectrum. Waves shorter than 1 mm refer to the terahertz range. Their feature lies in that they are capable to percolate various materials and at the same time, they do not lead to atomic ionization of matter alternatively to X-rays.

“Terahertz radiation detectors are, as a rule, rather compact devices.  Nowadays, researchers from different countries are interested in the enhancement of their responsivity and other parameters.  The higher responsivity, the weaker signals can be received and more precise measurements can be carried out,” Oleg Minin, Professor of the Division for Electronic Engineering of the TPU School of Non-Destructive Testing, one of the authors of the article, says.

“Most researchers are trying to solve this problem by changing the design of the detector and the materials it is made from. It is complicated and often very expensive. Meanwhile, our solution is plain to see.”

In their experiments, the scientists used a microparticle in the form of the Teflon cube, an available dielectric material through which electromagnetic waves of the terahertz range are capable to percolate.  The cube was put on the surface of the detector.

“There is a responsive site inside of the detector.  The site can be made from various materials but its typical scale is always less than the wavelength.  It is the area responsible for trapping electromagnetic waves and transferring them. Due to the form and material, our cube possesses a capability to focalize radiation well, falling on the responsive site of the detector, in the scale limited to or smaller than a diffraction-limited system. The experiments conducted jointly with the Spanish colleagues proved it: the particle focalized the radiation and the emitted radiation fell into the responsive area,” Oleg Minin explains.

According to the scientists, the developed method of detector responsivity enhancement without changing its design is applied to almost any detectors of various ranges.

During the experiments, the scientists fixed responsivity enhancement by 11 decibels, which is 3.5 folds higher than the standard parameters of the detector.

The researchers from the University of Salamanca (Spain), Polytechnic University of Valencia (Spain), Institute of High-Pressure Physics of the Polish Academy of Sciences (Poland) and Imperial College London (England) took part in the research. The research was conducted with the support of the TPU Competitiveness Enhancement Program.

LETI researchers help evaluate the effectiveness of new medicines

Nowadays, objective analysis and interpretation of biomedical research results are largely dependent on the fast and efficient processing of biomedical images, including tomographic images, histological samples, microphotographs of tissues, bacterial colonies, and other biological structures. ETU “LETI” scientists have proposed an innovative way to quickly process micro-images to assess the effectiveness of promising wound-healing drugs.

“The fact that biomedical images are non-stationary and heterogeneous makes automatic selection and classification of objects difficult. That makes developing specialized methods for their analysis, adapted to these properties, relevant. ETU “LETI” scientists have researched in the field of visual data analysis for several years. Analysis of biomedical visual data is one of the main areas of application of the developed methods and approaches,” notes Mikhail Bogachev, Chief Researcher of the Research Center “Digital Telecommunication Technologies” at ETU “LETI.”

One of the research areas is the automated analysis of images obtained using microscopy. St. Petersburg scientists have developed a modified method for analyzing microimages of aggregated bacterial cells. In such structures, it is impossible to distinguish individual cells in the image, so to evaluate subpopulations, LETI scientists suggested using a two-step algorithm based on a combination of selection and counting of individual cells.

Researchers analyzed the shape of objects highlighted in tissue sections to reconstruct the properties of the recovered tissue based on the biomechanical model developed by experts from Kazan Federal University. The results confirmed not only the accelerated wound healing but also the more natural structure of the recovered tissue, close to normal in its biomechanical properties, due to the treatment. The research materials were presented in the International Journal of Biological Macromolecules at the end of 2020.

“The search for promising drugs is inextricably linked to an extensive screening of candidate molecules. Although modern bio- and chemoinformatics tools make it possible to pre-select the most likely candidates, the volume of experimental studies for their verification remains considerable and requires laborious and time-consuming work from experts,” ” says Mikhail Bogachev.

“The algorithms for evaluating cell subpopulations on microscopic images that we have developed allow us to reduce the expert workload and increase the objectivity of studies not only when studying Ficin, but also other promising drugs.”

The proposed algorithm is demanded among practitioners, as evidenced by several dozens of citations in biomedical publications. The current research is carried out in close collaboration with specialists from Pavlov St. Petersburg Medical University, Saint Petersburg Research Institute of Ear, Throat, Nose and Speech, Albrecht Center for Rehabilitation of People with Disabilities, and several other healthcare organizations.