Thammasat University hosts event on regional transformation in Southeast Asia

The College of Interdisciplinary Studies at Thammasat University organized a workshop on the topic “Regional Economic Cooperation and Social Cultural Changes: The Future of Sino-Thai Connectivity” at Thammasat University, Lampang Campus. The event aimed to exchange knowledge and perspectives on significant related issues, featuring expert faculty members from various disciplines, including linguistics, art, culture, natural resource management and environmental studies, as well as international relations, who participated in this meeting.

Professor Dong Hongjie from Xi’an University, People’s Republic of China, the distinguished
speaker at this event, reported on the latest advancements of the “China Studies Program,” which is overseen by the Chinese Ministry of Education. This program focuses on fostering connections and economic cooperation between China and Thailand, significantly influencing the social and cultural transformations in both nations.

Furthermore, the participating professors exchanged perspectives from their fields of expertise, discussing opportunities as well as challenges regarding the anticipated collaboration between China and Thailand in the future.

Associate Professor Dr. Saifon Suindramedhi, Dean of the College of Interdisciplinary
Studies at Thammasat University, emphasized that this meeting is part of the activities aimed at promoting international academic collaboration, in celebration of the 90th anniversary of Thammasat University and the 25th anniversary of the College of Interdisciplinary Studies.

This in-depth dialogue serves to strengthen the relationships among interdisciplinary expert
faculty members, while also establishing a crucial foundation for the development of knowledge and international academic collaboration in the future. The College will steadfastly continue to lead in research and innovation within fields that consistently and robustly integrate diverse disciplines. 

Fortified from land to sea: underground engineering and coastal protection drive sustainable growth

Land and resource limitations are becoming more prevalent as the global population expands. This is especially true in sprawling megacities where millions live within tight geographical boundaries.

Developing underground space could be a solution to address urban land scarcity. Urban subterranean space is often underutilised and its development could uncover new social, economic and environmental possibilities that shape the cities of tomorrow. Innovations that protect coastlines from erosion, prevent low-lying areas from being submerged and create space for urban development, especially in the face of rising sea levels caused by climate change, could be part of the future of coastal cities.

In response to urban challenges, researchers from NTU’s School of Civil and Environmental Engineering (CEE) are diving deep, literally, focusing on both developing space below ground and protecting coastal regions. These projects include new digital platforms to reduce costs and enhance safety in underground construction, and green building materials to stabilise shorelines and adapt to rising sea levels.

Supporting the school’s endeavours is the Centre for Urban Solutions (CUS)a multidisciplinary initiative to provide leadership in research and development of innovative solutions for sustainable living and infrastructure for future cities.

The centre seeks to address urban development challenges by integrating digital technologies, such as artificial intelligence (AI), into urban planning and construction.

Eyeing the depths

One area that CUS focuses on is underground engineering. In land-scarce cities, space is being created through not just upward expansion, such as high-rise buildings, but also downward development. This subterranean push fortifies the city for future expansion as well.

Assoc Prof Wu Wei, who heads CUS’ Underground Engineering Cluster, runs cross-functional teams pioneering digital solutions to manage the unpredictable underground. “Digging up to 100 metres deep poses significant engineering challenges, such as managing costs and controlling surface settlement to prevent accidents like the ground collapsing,” he explains, citing a spate of devastating sinkhole incidents that have occurred worldwide during construction projects.

His group has developed methods powered by AI to precisely map underground structures like cavities or boulders, employing machine learning to detect anomalies autonomously.

“Our machine learning algorithms sift through geological data to identify deeper and clearer anomalies compared to existing approaches. This method reduces costs, cuts the need for constant human supervision and greatly enhances the efficiency and accuracy of our underground assessments,” Assoc Prof Wu notes.

CEE researcher Asst Prof Shi Chao has similarly turned to transformative digital solutions for underground and coastal engineering. His research team uses algorithms and digital twins – virtual models that simulate subsurface conditions – to optimise the construction of underground infrastructure. These virtual models accelerate real-world predictions and analyses when assessing the suitability of underground spaces for use, minimising the need for physical testing.

“We harness emerging AI technology to combine geological knowledge and site-specific data to automatically build and update digital twins,” explains Asst Prof Shi, stressing the need for accurate underground modelling to reduce risks in safety and project failure.

His team has successfully applied the digital twin approach in Hong Kong, assessing conditions such as slope stability and the structural integrity of the seabed for land reclamation and tunnelling projects. In cities with limited land resources, digital twins can help mitigate the risks of building on challenging soil conditions.

“The success of our models in solving complex engineering challenges brings us closer to revolutionising civil engineering and integrating advanced technologies to improve the efficiency, safety and sustainability of our infrastructure,” adds Asst Prof Shi.

Safeguarding our shores

Meanwhile, cities with low-lying coastlines face the imminent threat of rising sea levels. Singapore’s latest national climate change study projects an increase of up to 1.15 metres in sea level by the end of the century, exceeding previous estimates.

Prof Chu Jian, Chair of CEE and Director of CUS, is leading the charge on two research projects under the Coastal Protection and Flood Resilience Institute Singapore to mitigate this threat: improving shoreline stability and exploring sustainable materials for coastal protection. His work could also support land reclamation projects through novel construction methods and improving soil properties to enhance the stability of reclaimed land.

One such innovation is biocement, a durable and sustainable cement alternative produced from waste byproducts, embodying circular economy principles. The material could be used to build tube-like bunds along the coastline that protect beaches from strong waves and accumulate sediments like sand. In time, the bunds could help restore eroded shorelines and prevent further erosion due to rising sea levels.

“We tested biocement as a solution to prevent beach erosion at East Coast Park in a pilot project carried out with the National Parks Board, a Singapore public agency. Evaluations of the tests are underway,” says Prof Chu.

Currently, about 70% of Singapore’s coastline is safeguarded by coastal protection structures such as seawalls. Now, CUS researchers are working with national coastal protection agency PUB and the industry to develop alternative coastal protection structures using modular floating concrete units with impervious flexible seawalls that can adjust to changing sea levels. These structures could serve as coastal protection solutions that are multifunctional in incorporating roads and recreational spaces within or at the top of the modular units.

The work at CEE and CUS emphasises balancing engineering ingenuity with environmental sustainability. “We are taking a holistic approach to coastal protection and water management strategies. It’s important to design solutions that have minimal impact on the environment, which is why we harness nature-based innovations,” shares Prof Chu.

Prof Chu is optimistic about the research outcomes of CEE and CUS, which are bolstered by strategic collaborations with industry and government. “Most of our research projects are funded by government agencies or industries that address national needs directly,” he says. “All the work contributes to building up a city’s resilience against the changing climate.”

NTU–Harvard Collaboration Reveals Mechanism Behind Meiosis and Genetic Diversity

Have you ever wondered how our genetic diversity arises? During meiosis, parental chromosomes exchange genetic material, a critical process that fosters diversity within populations. Yet ensuring both precision in this exchange and overall genomic stability has posed a longstanding question in biology. Now, a joint research team from National Taiwan University (NTU) and Harvard University has uncovered a pivotal protein mechanism that could reshape our understanding of meiosis.

A Newly Discovered Regulatory Role

In a study recently published in Nature Communications, the research groups of Professor Hung-Yuan Ji (Graduate Institute of Biochemical Sciences, NTU), Professor Hong-Wen Lee (Department of Chemistry, NTU), and Professor Mara Prentiss (Department of Physics, Harvard University) demonstrated that a protein complex called Hop2-Mnd1 not only stimulates but also selectively suppresses the DNA recombinase Dmc1—depending on the degree of sequence similarity between DNA strands.

Previously, Hop2-Mnd1 was generally regarded as a co-factor that boosts the activity of Dmc1. The recombinase Dmc1 catalyzes DNA strand exchange between homologous chromosomes during meiosis, thereby enabling genetic diversity. If Dmc1 inadvertently promotes exchange of mismatched DNA sequences, the genome can become unstable, potentially leading to mutations and disease. Precisely how the cell ensures correct pairings while maintaining diversity has remained a key puzzle.

Experiment Design and Key Findings

To tackle this question, the researchers produced high-purity Hop2-Mnd1 and Dmc1 proteins, then designed multiple DNA substrates with varying degrees of sequence similarity.

  1. Exact or minimal mismatch: Hop2-Mnd1 enhanced Dmc1 activity, facilitating proper strand exchange.
  2. Low similarity: Hop2-Mnd1 inhibited Dmc1 function, preventing erroneous DNA pairing.

By analyzing protein–protein interactions in detail, the team confirmed that Hop2-Mnd1 exerts this selective control through direct binding with Dmc1. In other words, Hop2-Mnd1 actively “reads” the DNA context and modulates Dmc1 accordingly, ensuring that DNA exchanges occur predominantly between truly homologous sequences.

Significance of the Discovery

This mechanism sheds light on how meiotic cells avert potentially harmful recombination events, safeguarding genomic integrity. Beyond clarifying the process of meiosis, the Hop2-Mnd1 system opens new avenues for exploring genetic diseases, which often emerge when DNA repair and recombination pathways malfunction. The study thereby not only refines textbook knowledge on Hop2-Mnd1 but also suggests possible diagnostic or therapeutic targets for conditions related to recombination errors.

Interdisciplinary Collaboration

A notable aspect of this research is its strong interdisciplinary framework. The participants—Ms. Jo-Ching Peng, Mr. Hao-Yen Chang, and Ms. Yu-Ting Sun—brought together expertise from biochemistry, chemistry, and physics. Combining skill sets from NTU’s Graduate Institute of Biochemical Sciences and Department of Chemistry, along with resources at Harvard University, exemplifies how cross-institutional teamwork can drive breakthroughs in fundamental biology.

Future Directions

While this study targets one specific step in the meiotic machinery, the implications are broader. Understanding how Hop2-Mnd1 selectively guides Dmc1 could eventually help researchers manipulate recombination in agricultural or biomedical applications, possibly enhancing crop genetic diversity or devising novel treatments for genetic disorders. Additionally, the findings open up questions about whether other proteins exhibit a similarly precise mechanism for monitoring DNA sequence similarity. Exploring such possibilities may reveal deeper evolutionary strategies that balance genome stability with the need for diversity.

Publication

The complete research findings are available in Nature Communications:

https://www.nature.com/articles/s41467-024-53641-3