People over 60 are more likely to experience degenerative-dystrophic diseases of connective tissue. One of the most common diseases is osteoarthritis, which significantly worsens patients’ life quality.
The IKBFU Institute of Living Systems conducted a scoping study, the results of which are likely to help develop new therapies of joint failure.
The process of population aging is steadily accelerating not only in Russia but also in most European countries. One of the most common diseases of connective tissue is osteoarthritis, which significantly worsens the quality of life of patients. The disease affects the cartilage tissue in the joints. Osteoarthritis is one of the main causes of premature disability, second only to coronary heart disease in this respect.
The IKBFU researchers have studied the world trends in the classification of osteoarthritis, described and compared methods of obtaining modern chondroprotectors – collagen-based preparations used for the prevention and treatment of the disease. Scientists have reviewed the areas of production, research, and application of chondroprotectors in the modern conditions of science and technology development.
Stanislav Sukhikh, Head of the IKBFU Laboratory of Microbiology and Biotechnology:“Our study allowed us to classify osteoarthritis by the degree of severity, to study the effectiveness of drugs with chondroprotective properties within the progress of the disease’s development. We identified sources of collagen-containing raw materials. We have described the mechanisms of action of chondroprotective drugs (chondroitin sulfate, glucosamine sulfate or hydrochloride, hyaluronic acid, mucopolysaccharides, extraction drugs from animals or plant raw materials), their composition and properties.”
“And we came to the conclusion that the current treatment of osteoarthritis shifts to cell therapy, in particular, the use of stem cells”.
According to the scientist, the results will be used in practice to find new ways of treating degenerative-dystrophic diseases of connective tissue.
Dr. Sukhikh concluded:“This, in turn, will make a significant contribution to the solution of the world social and economic problem – complex therapy of osteoarthritis aimed at normalization of functional ability of affected joints”.
The results of the research conducted by Olga Babich, Director of the IKBFU Institute of Living Systems, and Stanislav Sukhih, Researcher at the Institute jointly with colleagues from Kemerovo State University were published in “Pharmaceuticals” Scientific Journal. The research was funded by the Russian Foundation for Basic Research.